Unsupervised Cross-Domain Feature Extraction for Single Blood Cell Image Classification
Institute of AI for Health, Helmholtz Munich – German Research Center for Environmental Health（亥姆霍兹慕尼黑中心——德国环境健康研究中心健康人工智能研究所）；Politecnico Di Torino（都灵理工大学）；Technical University of Munich（慕尼黑工业大学）；Johns Hopkins University（约翰斯·霍普金斯大学）；University Hospital Bonn（波恩大学医院）；Helmholtz AI, Helmholtz Munich – German Research Center for Environmental Health（亥姆霍兹慕尼黑中心——德国环境健康研究中心亥姆霍兹人工智能）
Diagnosing hematological malignancies requires identification and classification of white blood cells in peripheral blood smears. Domain shifts caused by different lab procedures, staining, illumination, and microscope settings hamper the re-usability of recently developed machine learning methods on data collected from different sites. Here, we propose a cross-domain adapted autoencoder to extract features in an unsupervised manner on three different datasets of single white blood cells scanned from peripheral blood smears. The autoencoder is based on an R-CNN architecture allowing it to focus on the relevant white blood cell and eliminate artifacts in the image. To evaluate the quality of the extracted features we use a simple random forest to classify single cells. We show that thanks to the rich features extracted by the autoencoder trained on only one of the datasets, the random forest classifier performs satisfactorily on the unseen datasets, and outperforms published oracle networks in the cross-domain task. Our results suggest the possibility of employing this unsupervised approach in more complicated diagnosis and prognosis tasks without the need to add expensive expert labels to unseen data.
In this paper an efficient approach for human face recognition based on the use of minutiae points in thermal face image is proposed. The thermogram of human face is captured by thermal infra-red camera. Image processing methods are used to pre-process the captured thermogram, from which different physiological features based on blood perfusion data are extracted. Blood perfusion data are related to distribution of blood vessels under the face skin. In the present work, three different methods have been used to get the blood perfusion image, namely bit-plane slicing and medial axis transform, …
This paper introduces the use of single layer and deep convolutional networks for remote sensing data analysis. Direct application to multi- and hyper-spectral imagery of supervised (shallow or deep) convolutional networks is very challenging given the high input data dimensionality and the relatively small amount of available labeled data. Therefore, we propose the use of greedy layer-wise unsupervised pre-training coupled with a highly efficient algorithm for unsupervised learning of sparse features. The algorithm is rooted on sparse representations and enforces both population and lifetime …
ITER, Siksha ‘O’ Anusandhan (Deemed to be University)（ITER，锡克沙·奥·阿努桑德汉（被视为大学））
In the medical domain, different computer-aided diagnosis systems have been proposed to extract blood vessels from retinal fundus images for the clinical treatment of vascular diseases. Accurate extraction of blood vessels from the fundus images using a computer-generated method can help the clinician to produce timely and accurate reports for the patient suffering from these diseases. In this article, we integrate top-hat based preprocessing approach with fine-tuned B-COSFIRE filter to achieve more accurate segregation of blood vessel pixels from the background. The use of top-hat transformat…
Tel Aviv University（特拉维夫大学）；Facebook AI Research（脸书人工智能研究院）
The task of blood vessel segmentation in microscopy images is crucial for many diagnostic and research applications. However, vessels can look vastly different, depending on the transient imaging conditions, and collecting data for supervised training is laborious. We present a novel deep learning method for unsupervised segmentation of blood vessels. The method is inspired by the field of active contours and we introduce a new loss term, which is based on the morphological Active Contours Without Edges (ACWE) optimization method. The role of the morphological operators is played by novel pool…
Photoplethysmographic imaging is a camera-based solution for non-contact cardiovascular monitoring from a distance. This technology enables monitoring in situations where contact-based devices may be problematic or infeasible, such as ambulatory, sleep, and multi-individual monitoring. However, extracting the blood pulse waveform signal is challenging due to the unknown mixture of relevant (pulsatile) and irrelevant pixels in the scene. Here, we design and implement a signal fusion framework, FusionPPG, for extracting a blood pulse waveform signal with strong temporal fidelity from a scene wit…
X-GAN: A Generative AI-Powered Unsupervised Model for Main Vessel Segmentation of Glaucoma Screening
Southern Methodist University（南方 Methodist 大学）；National Aeronautics and Space Administration（美国国家航空航天局）；University of Texas Southwestern Medical Center（德克萨斯西南医学中心）；Northeastern University（东北大学）
Bangladesh University of Engineering and Technology (BUET)（孟加拉国工程技术大学（BUET））；Georgia Institute of Technology（佐治亚理工学院）
Successful identification of blood vessel blockage is a crucial step for Alzheimer's disease diagnosis. These blocks can be identified from the spatial and time-depth variable Two-Photon Excitation Microscopy (TPEF) images of the brain blood vessels using machine learning methods. In this study, we propose several preprocessing schemes to improve the performance of these methods. Our method includes 3D-point cloud data extraction from image modality and their feature-space fusion to leverage complementary information inherent in different modalities. We also enforce the learned representation …
Tsinghua University（清华大学）；Beijing Anzhen Hospital, Capital Medical University（首都医科大学附属北京安贞医院）；The First Affiliated Hospital of Zhengzhou University（郑州大学第一附属医院）
Coronary angiography is an indispensable assistive technique for cardiac interventional surgery. Segmentation and extraction of blood vessels from coronary angiography videos are very essential prerequisites for physicians to locate, assess and diagnose the plaques and stenosis in blood vessels. This article proposes a new video segmentation framework that can extract the clearest and most comprehensive coronary angiography images from a video sequence, thereby helping physicians to better observe the condition of blood vessels. This framework combines a 3D convolutional layer to extract spati…
Hazara University（哈扎拉大学）；National University of Sciences & Technology (NUST)（国家科技大学）
Previous works on segmentation of SEM (scanning electron microscope) blood cell image ignore the semantic segmentation approach of whole-slide blood cell segmentation. In the proposed work, we address the problem of whole-slide blood cell segmentation using the semantic segmentation approach. We design a novel convolutional encoder-decoder framework along with VGG-16 as the pixel-level feature extraction model. -e proposed framework comprises 3 main steps: First, all the original images along with manually generated ground truth masks of each blood cell type are passed through the preprocessin…
Automatic extraction of buildings in urban scenes has become a subject of growing interest in the domain of photogrammetry and remote sensing, particularly with the emergence of LiDAR systems since mid-1990s. However, in reality, this task is still very challenging due to the complexity of building size and shapes, as well as its surrounding environment. Active contour model, colloquially called snake model, which has been extensively used in many applications in computer vision and image processing, is also applied to extract buildings from aerial/satellite imagery. Motivated by the limitatio…
Deepwise AI Lab（深度智耀人工智能实验室）；Northwestern Polytechnical University（西北工业大学）；Peking University（北京大学）
Analyzing the morphological attributes of blood vessels plays a critical role in the computer-aided diagnosis of many cardiovascular and ophthalmologic diseases. Although being extensively studied, segmentation of blood vessels, particularly thin vessels and capillaries, remains challenging mainly due to the lack of an effective interaction between local and global features. In this paper, we propose a novel deep learning model called PC-Net to segment retinal vessels and major arteries in 2D fundus image and 3D computed tomography angiography (CTA) scans, respectively. In PC-Net, the pyramid …
East China Normal University（华东师范大学）；Ryerson University（瑞尔森大学）
Sturge-Weber syndrome (SWS) is a vascular malformation disease, and it may cause blindness if the patient's condition is severe. Clinical results show that SWS can be divided into two types based on the characteristics of scleral blood vessels. Therefore, how to accurately segment scleral blood vessels has become a significant problem in computer-aided diagnosis. In this research, we propose to continuously upsample the bottom layer's feature maps to preserve image details, and design a novel Claw UNet based on UNet for scleral blood vessel segmentation. Specifically, the residual structure is…
University of Tehran（德黑兰大学）；Nimaad Health Equipment Development Company（Nimaad健康设备开发公司）；K. N. Toosi University of Technology（K. N. Toosi理工大学）
The nucleus of white blood cells (WBCs) plays a significant role in their detection and classification. Appropriate feature extraction of the nucleus is necessary to fit a suitable artificial intelligence model to classify WBCs. Therefore, designing a method is needed to segment the nucleus accurately. There should be a comparison between the ground truths distinguished by a hematologist and the detected nuclei to evaluate the performance of the nucleus segmentation method accurately. It is a time-consuming and tedious task for experts to establish the ground truth manually. This paper present…
Subtle periodic signals such as blood volume pulse and respiration can be extracted from RGB video, enabling remote health monitoring at low cost. Advancements in remote pulse estimation -- or remote photoplethysmography (rPPG) -- are currently driven by deep learning solutions. However, modern approaches are trained and evaluated on benchmark datasets with associated ground truth from contact-PPG sensors. We present the first non-contrastive unsupervised learning framework for signal regression to break free from the constraints of labelled video data. With minimal assumptions of periodicity …
Shantou University（汕头大学）；South China University of Technology（华南理工大学）；Nanjing University of Aeronautics and Astronautics（南京航空航天大学）；Soochow University（苏州大学）
In this paper, a hierarchical image matting model is proposed to extract blood vessels from fundus images. More specifically, a hierarchical strategy utilizing the continuity and extendibility of retinal blood vessels is integrated into the image matting model for blood vessel segmentation. Normally the matting models require the user specified trimap, which separates the input image into three regions manually: the foreground, background and unknown regions. However, since creating a user specified trimap is a tedious and time-consuming task, region features of blood vessels are used to gener…
Automated segmentation of vascular map in retinal images endeavors a potential benefit in diagnostic procedure of different ocular diseases. In this paper, we suggest a new unsupervised retinal blood vessel segmentation approach using top-hat transformation, contrast-limited adaptive histogram equalization (CLAHE), and 2-D Gabor wavelet filters. Initially, retinal image is preprocessed using top-hat morphological transformation followed by CLAHE to enhance only the blood vessel pixels in the presence of exudates, optic disc, and fovea. Then, multiscale 2-D Gabor wavelet filters are applied on …
This paper represents an text extraction method from Google maps, GIS maps/images. Due to an unsupervised approach there is no requirement of any prior knowledge or training set about the textual and non-textual parts. Fuzzy CMeans clustering technique is used for image segmentation and Prewitt method is used to detect the edges. Connected component analysis and gridding technique enhance the correctness of the results. The proposed method reaches 98.5% accuracy level on the basis of experimental data sets.
SOM is a type of unsupervised learning where the goal is to discover some underlying structure of the data. In this paper, a new extraction method based on the main idea of Concurrent Self-Organizing Maps (CSOM), representing a winner-takes-all collection of small SOM networks is proposed. Each SOM of the system is trained individually to provide best results for one class only. The experiments confirm that the proposed features based CSOM is capable to represent image content better than extracted features based on a single big SOM and these proposed features improve the final decision of the…
Existing methods to reconstruct vascular structures from a computed tomography (CT) angiogram rely on injection of intravenous contrast to enhance the radio-density within the vessel lumen. However, pathological changes can be present in the blood lumen, vessel wall or a combination of both that prevent accurate reconstruction. In the example of aortic aneurysmal disease, a blood clot or thrombus adherent to the aortic wall within the expanding aneurysmal sac is present in 70-80% of cases. These deformations prevent the automatic extraction of vital clinically relevant information by current m…
Brain extraction and registration are important preprocessing steps in neuroimaging data analysis, where the goal is to extract the brain regions from MRI scans (i.e., extraction step) and align them with a target brain image (i.e., registration step). Conventional research mainly focuses on developing methods for the extraction and registration tasks separately under supervised settings. The performance of these methods highly depends on the amount of training samples and visual inspections performed by experts for error correction. However, in many medical studies, collecting voxel-level lab…
The Self-Organizing Map (SOM) is a brain-inspired neural model that is very promising for unsupervised learning, especially in embedded applications. However, it is unable to learn efficient prototypes when dealing with complex datasets. We propose in this work to improve the SOM performance by using extracted features instead of raw data. We conduct a comparative study on the SOM classification accuracy with unsupervised feature extraction using two different approaches: a machine learning approach with Sparse Convolutional Auto-Encoders using gradient-based learning, and a neuroscience appro…
Today, finger vein identification is gaining popularity as a potential biometric identification framework solution. Machine learning-based unsupervised, supervised, and deep learning algorithms have had a significant influence on finger vein detection and recognition at the moment. Deep learning, on the other hand, necessitates a large number of training datasets that must be manually produced and labeled. In this research, we offer a completely automated unsupervised learning strategy for training dataset creation. Our method is intended to extract and build a decent binary mask training data…
Automatic extraction of buildings in urban and residential scenes has become a subject of growing interest in the domain of photogrammetry and remote sensing, particularly since mid-1990s. Active contour model, colloquially known as snake model, has been studied to extract buildings from aerial and satellite imagery. However, this task is still very challenging due to the complexity of building size, shape, and its surrounding environment. This complexity leads to a major obstacle for carrying out a reliable large-scale building extraction, since the involved prior information and assumptions …
Unsupervised learning methods for feature extraction are becoming more and more popular. We combine the popular contrastive learning method (prototypical contrastive learning) and the classic representation learning method (autoencoder) to design an unsupervised feature learning network for hyperspectral classification. Experiments have proved that our two proposed autoencoder networks have good feature learning capabilities by themselves, and the contrastive learning network we designed can better combine the features of the two to learn more representative features. As a result, our method s…
Indian Institute of Engineering Science and Technology, Shibpur（印度希布尔工程科学技术学院）；Indian Institute of Space Science and Technology（印度空间科学技术学院）
We present an improved clustering based, unsupervised anomalous trajectory detection algorithm for crowded scenes. The proposed work is based on four major steps, namely, extraction of trajectories from crowded scene video, extraction of several features from these trajectories, independent mean-shift clustering and anomaly detection. First, the trajectories of all moving objects in a crowd are extracted using a multi feature video object tracker. These trajectories are then transformed into a set of feature spaces. Mean shift clustering is applied on these feature matrices to obtain distinct …
Skolkovo Institute of Science and Technology（斯科尔科沃科学技术研究院）
Unsupervised retrieval of image features is vital for many computer vision tasks where the annotation is missing or scarce. In this work, we propose a new unsupervised approach to detect the landmarks in images, validating it on the popular task of human face key-points extraction. The method is based on the idea of auto-encoding the wanted landmarks in the latent space while discarding the non-essential information (and effectively preserving the interpretability). The interpretable latent space representation (the bottleneck containing nothing but the wanted key-points) is achieved by a new …
Simon Fraser University（西蒙弗雷泽大学）；National University of Defense Technology（国防科技大学）；Microsoft Research（微软研究院）
We present a method for estimating detailed scene illumination using human faces in a single image. In contrast to previous works that estimate lighting in terms of low-order basis functions or distant point lights, our technique estimates illumination at a higher precision in the form of a non-parametric environment map. Based on the observation that faces can exhibit strong highlight reflections from a broad range of lighting directions, we propose a deep neural network for extracting highlights from faces, and then trace these reflections back to the scene to acquire the environment map. Si…
University of Massachusetts（马萨诸塞大学）；College of Information and Computer Science（信息与计算机科学学院）
Video is one of the robust sources of information and the consumption of online and offline videos has reached an unprecedented level in the last few years. A fundamental challenge of extracting information from videos is a viewer has to go through the complete video to understand the context, as opposed to an image where the viewer can extract information from a single frame. Apart from context understanding, it almost impossible to create a universal summarized video for everyone, as everyone has their own bias of keyframe, e.g; In a soccer game, a coach person might consider those frames wh…
Leukemia (blood cancer) is an unusual spread of White Blood Cells or Leukocytes (WBCs) in the bone marrow and blood. Pathologists can diagnose leukemia by looking at a person's blood sample under a microscope. They identify and categorize leukemia by counting various blood cells and morphological features. This technique is time-consuming for the prediction of leukemia. The pathologist's professional skills and experiences may be affecting this procedure, too. In computer vision, traditional machine learning and deep learning techniques are practical roadmaps that increase the accuracy and spe…
At least two software packages---DARWIN, Eckerd College, and FinScan, Texas A&M---exist to facilitate the identification of cetaceans---whales, dolphins, porpoises---based upon the naturally occurring features along the edges of their dorsal fins. Such identification is useful for biological studies of population, social interaction, migration, etc. The process whereby fin outlines are extracted in current fin-recognition software packages is manually intensive and represents a major user input bottleneck: it is both time consuming and visually fatiguing. This research aims to develop automate…
The diagnosis of blood-based diseases often involves identifying and characterizing patient blood samples. Automated methods to detect and classify blood cell subtypes have important medical applications. Automated medical image processing and analysis offers a powerful tool for medical diagnosis. In this work we tackle the problem of white blood cell classification based on the morphological characteristics of their outer contour, color. The work we would explore a set of preprocessing and segmentation (Color-based segmentation, Morphological processing, contouring) algorithms along with a se…
Domain-invariant Representation Learning via Segment Anything Model for Blood Cell Classification
College of Big Data and Internet, Shenzhen Technology University（深圳技术大学大数据与互联网学院）；The Third Affiliated Hospital of Sun Yat-sen University（中山大学附属第三医院）；School of Computer Science, South China Normal University（华南师范大学计算机学院）
The World Health Organization has listed the design of safer intersections as a key intervention to reduce global road trauma. This article presents the first study to systematically analyze the design of all intersections in a large country, based on aerial imagery and deep learning. Approximately 900,000 satellite images were downloaded for all intersections in Australia and customized computer vision techniques emphasized the road infrastructure. A deep autoencoder extracted high-level features, including the intersection's type, size, shape, lane markings, and complexity, which were used t…
In the majority of the existing Visual Question Answering (VQA) research, the answers consist of short, often single words, as per instructions given to the annotators during dataset construction. This study envisions a VQA task for natural situations, where the answers are more likely to be sentences rather than single words. To bridge the gap between this natural VQA and existing VQA approaches, a novel unsupervised keyword extraction method is proposed. The method is based on the principle that the full-sentence answers can be decomposed into two parts: one that contains new information ans…
Harbin Institute of Technology（哈尔滨工业大学）；Wuhan University（武汉大学）；University of Central Florida（中佛罗里达大学）；China University of Geosciences（中国地质大学）
As an unsupervised dimensionality reduction method, principal component analysis (PCA) has been widely considered as an efficient and effective preprocessing step for hyperspectral image (HSI) processing and analysis tasks. It takes each band as a whole and globally extracts the most representative bands. However, different homogeneous regions correspond to different objects, whose spectral features are diverse. It is obviously inappropriate to carry out dimensionality reduction through a unified projection for an entire HSI. In this paper, a simple but very effective superpixelwise PCA approa…
With the growing popularity of short-form video sharing platforms such as \em{Instagram} and \em{Vine}, there has been an increasing need for techniques that automatically extract highlights from video. Whereas prior works have approached this problem with heuristic rules or supervised learning, we present an unsupervised learning approach that takes advantage of the abundance of user-edited videos on social media websites such as YouTube. Based on the idea that the most significant sub-events within a video class are commonly present among edited videos while less interesting ones appear less…
Numerous online stock image libraries offer high quality yet copyright free images for use in marketing campaigns. To assist advertisers in navigating such third party libraries, we study the problem of automatically fetching relevant ad images given the ad text (via a short textual query for images). Motivated by our observations in logged data on ad image search queries (given ad text), we formulate a keyword extraction problem, where a keyword extracted from the ad text (or its augmented version) serves as the ad image query. In this context, we propose VisualTextRank: an unsupervised metho…
The success of StyleGAN has enabled unprecedented semantic editing capabilities, on both synthesized and real images. However, such editing operations are either trained with semantic supervision or described using human guidance. In another development, the CLIP architecture has been trained with internet-scale image and text pairings and has been shown to be useful in several zero-shot learning settings. In this work, we investigate how to effectively link the pretrained latent spaces of StyleGAN and CLIP, which in turn allows us to automatically extract semantically labeled edit directions …
ETH Zurich（苏黎世联邦理工学院）；University of Trento（特伦托大学）；Guangdong University of Petrochemical Technology（广东石油化工学院）
Video processing and analysis have become an urgent task since a huge amount of videos (e.g., Youtube, Hulu) are uploaded online every day. The extraction of representative key frames from videos is very important in video processing and analysis since it greatly reduces computing resources and time. Although great progress has been made recently, large-scale video classification remains an open problem, as the existing methods have not well balanced the performance and efficiency simultaneously. To tackle this problem, this work presents an unsupervised method to retrieve the key frames, whic…
Mitsubishi Electric Research Labs (MERL)（三菱电机研究实验室）；University of Illinois, Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；University of Maryland, College Park（马里兰大学学院市分校）
Over the years, computer vision researchers have spent an immense amount of effort on designing image features for the visual object recognition task. We propose to incorporate this valuable experience to guide the task of training deep neural networks. Our idea is to pretrain the network through the task of replicating the process of hand-designed feature extraction. By learning to replicate the process, the neural network integrates previous research knowledge and learns to model visual objects in a way similar to the hand-designed features. In the succeeding finetuning step, it further lear…
Biomedical Engineering and Neuroscience Program, The MARCS Institute for Brain, Behaviour, and Development, Western Sydney University（西悉尼大学MARCS脑、行为与发展研究所生物医学工程与神经科学项目）
In this paper we compare event-based decaying and time based-decaying memory surfaces for high-speed eventbased tracking, feature extraction, and object classification using an event-based camera. The high-speed recognition task involves detecting and classifying model airplanes that are dropped free-hand close to the camera lens so as to generate a challenging dataset exhibiting significant variance in target velocity. This variance motivated the investigation of event-based decaying memory surfaces in comparison to time-based decaying memory surfaces to capture the temporal aspect of the eve…
Stony Brook University（石溪大学）；Oak Ridge National Laboratory（橡树岭国家实验室）；Stony Brook University Hospital（石溪大学医院）
Histopathology images are crucial to the study of complex diseases such as cancer. The histologic characteristics of nuclei play a key role in disease diagnosis, prognosis and analysis. In this work, we propose a sparse Convolutional Autoencoder (CAE) for fully unsupervised, simultaneous nucleus detection and feature extraction in histopathology tissue images. Our CAE detects and encodes nuclei in image patches in tissue images into sparse feature maps that encode both the location and appearance of nuclei. Our CAE is the first unsupervised detection network for computer vision applications. T…
Multimodal Analysis of White Blood Cell Differentiation in Acute Myeloid Leukemia Patients using a β-Variational Autoencoder
Institute of AI for Health, Helmholtz Zentrum München – German Research Center for Environmental Health（慕尼黑亥姆霍兹中心人工智能健康研究所（德国环境健康研究中心））；University of Trento（特伦托大学）；Technical University of Munich（慕尼黑工业大学）；Ludwig-Maximilians University Munich（慕尼黑大学）；Johns Hopkins University（约翰斯·霍普金斯大学）
BioVessel-Net and RetinaMix: Unsupervised Retinal Vessel Segmentation from OCTA Images
University of Electronic Science and Technology of China（电子科技大学）；Southern Methodist University（南方法律大学）；University of Texas Southwestern Medical Center（德克萨斯西南医学中心）；University Medical Center Utrecht（乌得勒支大学医学中心）；Georgetown University（杰斐逊大学）；Sichuan Provincial People’s Hospital（四川省级人民医院）；University of Connecticut（康涅狄格大学）
