内外环境相互作用在肿瘤侵袭行为中的作用
Role of the Interplay Between the Internal and External Conditions in Invasive Behavior of Tumors
摘要：
肿瘤生长在癌症演变中起着核心作用，它取决于细胞的内部特征，例如它们无限复制的能力，以及外部条件，例如，营养物质的供应，以及两者之间的动态相互作用。最近发展了癌症的干细胞理论，该理论表明存在自我更新的肿瘤细胞亚群，其负责肿瘤发生，并且能够启动转移扩散。然而，癌症干细胞（CSCs）的丰度及其与肿瘤恶性程度的关系的问题仍然是一个未解决的问题，并且一直是最近辩论的主题。在本文中，我们提出了一个新的模型超越了标准的肿瘤发展的随机模型，以探讨肿瘤细胞的密度和氧气对肿瘤的侵袭行为的影响。该模型将自然选择确定为实验观察到的肿瘤复杂形态的潜在过程，并表明它们的侵袭行为取决于{ \it两者} CSC的数量和微环境中的氧密度。外部和内部条件之间的相互作用可能为新的癌症治疗铺平道路。
英文摘要：
Tumor growth, which plays a central role in cancer evolution, depends on both the internal features of the cells, such as their ability for unlimited duplication, and the external conditions, e.g., supply of nutrients, as well as the dynamic interactions between the two. A stem cell theory of cancer has recently been developed that suggests the existence of a subpopulation of self-renewing tumor cells which is responsible for tumorigenesis, and is able to initiate metastatic spreading. The question of abundance of the cancer stem cells (CSCs) and its relation to tumor malignancy has, however, remained an unsolved problem and has been a subject of recent debates. In this paper, we propose a novel model beyond the standard stochastic models of tumor development, in order to explore the effect of the density of the CSCs and oxygen on the tumor's invasive behavior. The model identifies natural selection as the underlying process for complex morphology of tumors, which has been observed experimentally, and indicates that their invasive behavior depends on {\it both} the number of the CSCs and the oxygen density in the microenvironment. The interplay between the external and internal conditions may pave the way for a new cancer therapy.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
