癌症侵袭的物理方面
Physical Aspects of Cancer Invasion
摘要：
侵袭性是肿瘤进展的标志之一，代表肿瘤通过几个复杂的生物化学和生物力学过程扩展到宿主组织中的能力。由于该问题的某些方面与众所周知的物理机制存在惊人的相似之处，例如弹性材料样本中固体内含物的机械插入[1，2]或水滴撞击表面[3]，因此我们在此提出这些物理过程与癌症系统侵入周围组织的分支之间的类比。考虑到它的固体和粘性，我们提出了一个统一的概念，肿瘤的行为作为一个颗粒状固体。虽然我们的模型已经明确制定了多细胞肿瘤球体在体外，它也应该有助于更好地了解肿瘤在体内的侵袭。
英文摘要：
Invasiveness, one of the hallmarks of tumor progression, represents the tumor's ability to expand into the host tissue by means of several complex biochemical and biomechanical processes. Since certain aspects of the problem present a striking resemblance with well known physical mechanisms, such as the mechanical insertion of a solid inclusion in an elastic material specimen [1, 2] or a water drop impinging on a surface [3], we propose here an analogy between these physical processes and a cancer system's invasive branching into the surrounding tissue. Accounting for its solid and viscous properties, we present a unifying concept that the tumor behaves as a granular solid. While our model has been explicitly formulated for multicellular tumor spheroids in vitro, it should also contribute to a better understanding of tumor invasion in vivo.
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