Nonparametric estimation of the conditional expectation $E(Y | U)$ of an outcome $Y$ given a covariate vector $U$ is of primary importance in many statistical applications such as prediction and personalized medicine. In some problems, there is an additional auxiliary variable $Z$ in the training dataset used to construct estimators, but $Z$ is not available for future prediction or selecting patient treatment in personalized medicine. For example, in the training dataset longitudinal outcomes are observed, but only the last outcome $Y$ is concerned in the future prediction or analysis. The longitudinal outcomes other than the last point is then the variable $Z$ that is observed and related with both $Y$ and $U$. Previous work on how to make use of $Z$ in the estimation of $E(Y|U)$ mainly focused on using $Z$ in the construction of a linear function of $U$ to reduce covariate dimension for better estimation. Using $E(Y|U) = E\{E(Y|U, Z)| U\}$, we propose a two-step estimation of inner and outer expectations, respectively, with sufficient dimension reduction for kernel estimation in both steps. The information from $Z$ is utilized not only in dimension reduction, but also directly in the estimation. Because of the existence of different ways for dimension reduction, we construct two estimators that may improve the estimator without using $Z$. The improvements are shown in the convergence rate of estimators as the sample size increases to infinity as well as in the finite sample simulation performance. A real data analysis about the selection of mammography intervention is presented for illustration.
Many imputation methods are based on statistical models that assume that the variable of interest is a noisy observation of a function of the auxiliary variables or covariates. Misspecification of this model may lead to severe errors in estimates and to misleading conclusions. A new imputation method for item nonresponse in surveys is proposed based on a nonparametric estimation of the functional dependence between the variable of interest and the auxiliary variables. We consider the use of smoothing spline estimation within an additive model framework to flexibly build an imputation model in …
Truncated conditional expectation functions are objects of interest in a wide range of economic applications, including income inequality measurement, financial risk management, and impact evaluation. They typically involve truncating the outcome variable above or below certain quantiles of its conditional distribution. In this paper, based on local linear methods, a novel, two-stage, nonparametric estimator of such functions is proposed. In this estimation problem, the conditional quantile function is a nuisance parameter that has to be estimated in the first stage. The proposed estimator is …
In this paper, we consider the problem of estimating a conditional density in moderately large dimensions. Much more informative than regression functions, conditional densities are of main interest in recent methods, particularly in the Bayesian framework (studying the posterior distribution, finding its modes...). Considering a recently studied family of kernel estimators, we select a pointwise multivariate bandwidth by revisiting the greedy algorithm Rodeo (Regularisation Of Derivative Expectation Operator). The method addresses several issues: being greedy and computationally efficient by …
In this note we provide explicit expressions and expansions for a special function which appears in nonparametric estimation of log-densities. This function returns the integral of a log-linear function on a simplex of arbitrary dimension. In particular it is used in the R-package "LogCondDEAD" by Cule et al. (2007).
We identify the average dose-response function (ADRF) for a continuously valued error-contaminated treatment by a weighted conditional expectation. We then estimate the weights nonparametrically by maximising a local generalised empirical likelihood subject to an expanding set of conditional moment equations incorporated into the deconvolution kernels. Thereafter, we construct a deconvolution kernel estimator of ADRF. We derive the asymptotic bias and variance of our ADRF estimator and provide its asymptotic linear expansion, which helps conduct statistical inference. To select our smoothing p…
We demonstrate and discuss nonasymptotic bounds in probability for the cost of a regression scheme with a general loss function from the perspective of the Rademacher theory, and for the optimality with respect to the average $L^{2}$-distance to the underlying conditional expectations of least squares regression outcomes from the perspective of the Vapnik-Chervonenkis theory. The results follow from an analysis involving independent but possibly nonstationary training samples and can be extended, in a manner that we explain and illustrate, to relevant cases in which the training sample exhibit…
We derive estimators of the density of the event times of current status data. The estimators are derived for the situations where the distribution of the observation times is known and where this distribution is unknown. The density estimators are constructed from kernel estimators of the density of transformed current status data, which have a distribution similar to uniform deconvolution data. Expansions of the expectation and variance as well as asymptotic normality are derived. A reference density based bandwidth selection method is proposed. A simulated example is presented.
A method for change point detection is proposed. We consider a univariate sequence of independent random variables with piecewise constant expectation and variance, apart from which the distribution may vary periodically. We aim to detect change points in both expectation and variance. For that, we propose a statistical test for the null hypothesis of no change points and an algorithm for change point detection. Both are based on a bivariate moving sum approach that jointly evaluates the mean and the empirical variance. The joint consideration helps improve inference as compared to separate un…
In econometrics, many parameters of interest can be written as ratios of expectations. The main approach to construct confidence intervals for such parameters is the delta method. However, this asymptotic procedure yields intervals that may not be relevant for small sample sizes or, more generally, in a sequence-of-model framework that allows the expectation in the denominator to decrease to $0$ with the sample size. In this setting, we prove a generalization of the delta method for ratios of expectations and the consistency of the nonparametric percentile bootstrap. We also investigate finite…
Oriented circular cylinders in an opaque medium are used to represent certain microstructural objects in steel. The opaque medium is sliced parallel to the cylinder axes of symmetry and the cut-plane contains the observable rectangular profiles of the cylinders. A one-to-one relation between the joint density of the squared radius and height of the 3D cylinders and the joint density of the squared half-width and height of the observable 2D rectangles is established. We propose a nonparametric estimation procedure to estimate the distributions and expectations of various quantities of interest,…
Semiparametric single-index assumptions are convenient and widely used dimen\-sion reduction approaches that represent a compromise between the parametric and fully nonparametric models for regressions or conditional laws. In a mean regression setup, the SIM assumption means that the conditional expectation of the response given the vector of covariates is the same as the conditional expectation of the response given a scalar projection of the covariate vector. In a conditional distribution modeling, under the SIM assumption the conditional law of a response given the covariate vector coincide…
In this paper, we consider a functional linear regression model, where both the covariate and the response variable are functional random variables. We address the problem of optimal nonparametric estimation of the conditional expectation operator in this model. A collection of projection estimators over finite dimensional subspaces is first introduce. We provide a non-asymptotic bias-variance decomposition for the Mean Square Prediction error in the case where these subspaces are generated by the (empirical) PCA functional basis. The automatic trade-off is realized thanks to a model selection…
Fluorescence microscopy is widely used for the study of biological specimens. Deconvolution can significantly improve the resolution and contrast of images produced using fluorescence microscopy; in particular, Bayesian-based methods have become very popular in deconvolution fluorescence microscopy. An ongoing challenge with Bayesian-based methods is in dealing with the presence of noise in low SNR imaging conditions. In this study, we present a Bayesian-based method for performing deconvolution using dynamically updated nonparametric nonstationary expectation estimates that can improve the fl…
For the problem of nonparametric regression of smooth functions, we reconsider and analyze a constrained variational approach, which we call the MultIscale Nemirovski-Dantzig (MIND) estimator. This can be viewed as a multiscale extension of the Dantzig selector (\emph{Ann. Statist.}, 35(6): 2313--51, 2009) based on early ideas of Nemirovski (\emph{J. Comput. System Sci.}, 23:1--11, 1986). MIND minimizes a homogeneous Sobolev norm under the constraint that the multiresolution norm of the residual is bounded by a universal threshold. The main contribution of this paper is the derivation of conve…
We incorporate into the empirical measure the auxiliary information given by a finite collection of expectation in an optimal information geometry way. This allows to unify several methods exploiting a side information and to uniquely define an informed empirical measure. These methods are shown to share the same asymptotic properties. Then we study the informed empirical process subject to a true information. We establish the Glivenko-Cantelli and Donsker theorems for the informed empirical measure under minimal assumptions and we quantify the asymptotic uniform variance reduction. Moreover, …
We propose a roughness regularization approach in making nonparametric inference for generalized functional linear models. In a reproducing kernel Hilbert space framework, we construct asymptotically valid confidence intervals for regression mean, prediction intervals for future response and various statistical procedures for hypothesis testing. In particular, one procedure for testing global behaviors of the slope function is adaptive to the smoothness of the slope function and to the structure of the predictors. As a by-product, a new type of Wilks phenomenon [Ann. Math. Stat. 9 (1938) 60-62…
Genetic risk prediction is an important component of individualized medicine, but prediction accuracies remain low for many complex diseases. A fundamental limitation is the sample sizes of the studies on which the prediction algorithms are trained. One way to increase the effective sample size is to integrate information from previously existing studies. However, it can be difficult to find existing data that examine the target disease of interest, especially if that disease is rare or poorly studied. Furthermore, individual-level genotype data from these auxiliary studies are typically diffi…
For the nonparametric regression models with covariates contaminated with normal measurement errors, this paper proposes an extrapolation algorithm to estimate the nonparametric regression functions. By applying the conditional expectation directly to the kernel-weighted least squares of the deviations between the local linear approximation and the observed responses, the proposed algorithm successfully bypasses the simulation step needed in the classical simulation extrapolation method, thus significantly reducing the computational time. It is noted that the proposed method also provides an e…
Penalized spline smoothing is a popular and flexible method of obtaining estimates in nonparametric regression but the classical least-squares criterion is highly susceptible to model deviations and atypical observations. Penalized spline estimation with a resistant loss function is a natural remedy, yet to this day the asymptotic properties of M-type penalized spline estimators have not been studied. We show in this paper that M-type penalized spline estimators achieve the same rates of convergence as their least-squares counterparts, even with auxiliary scale estimation. We further find theo…
There are many interesting and widely used estimators of a functional with finite semiparametric variance bound that depend on nonparametric estimators of nuisance functions. We use cross-fitting (i.e. sample splitting) to construct novel estimators with fast remainder rates. We give cross-fit doubly robust estimators that use separate subsamples to estimate different nuisance functions. We obtain general, precise results for regression spline estimation of average linear functionals of conditional expectations with a finite semiparametric variance bound. We show that a cross-fit doubly robust…
Transfer learning has drawn growing attention with the target of improving statistical efficiency of one study (dataset) by digging information from similar and related auxiliary studies (datasets). In the article, we consider transfer learning problem in estimating undirected semi-parametric graphical model. We propose an algorithm called Trans-Copula-CLIME for estimating undirected graphical model while digging information from similar auxiliary studies, characterizing the similarity between the target graph and each auxiliary graph by the sparsity of a divergence matrix. The proposed method…
Link prediction is a fundamental task in statistical network analysis. Recent advances have been made on learning flexible nonparametric Bayesian latent feature models for link prediction. In this paper, we present a max-margin learning method for such nonparametric latent feature relational models. Our approach attempts to unite the ideas of max-margin learning and Bayesian nonparametrics to discover discriminative latent features for link prediction. It inherits the advances of nonparametric Bayesian methods to infer the unknown latent social dimension, while for discriminative link predicti…
Datasets from field experiments with covariate-adaptive randomizations (CARs) usually contain extra covariates in addition to the strata indicators. We propose to incorporate these additional covariates via auxiliary regressions in the estimation and inference of unconditional quantile treatment effects (QTEs) under CARs. We establish the consistency and limit distribution of the regression-adjusted QTE estimator and prove that the use of multiplier bootstrap inference is non-conservative under CARs. The auxiliary regression may be estimated parametrically, nonparametrically, or via regulariza…
Imputation is a popular technique for handling item nonresponse in survey sampling. Parametric imputation is based on a parametric model for imputation and is less robust against the failure of the imputation model. Nonparametric imputation is fully robust but is not applicable when the dimension of covariates is large due to the curse of dimensionality. Semiparametric imputation is another robust imputation based on a flexible model where the number of model parameters can increase with the sample size. In this paper, we propose another semiparametric imputation based on a more flexible model…
