Semi-Supervised Multi-Organ Segmentation via Deep Multi-Planar Co-Training
The Johns Hopkins University（约翰斯·霍普金斯大学）；Huazhong University of Science and Technology（华中科技大学）；University of Oxford（牛津大学）；The Johns Hopkins University School of Medicine（约翰斯·霍普金斯大学医学院）
Yuyin Zhou, Yan Wang, Peng Tang, Song Bai, Wei Shen, Elliot K. Fishman, Alan L. Yuille
In multi-organ segmentation of abdominal CT scans, most existing fully supervised deep learning algorithms require lots of voxel-wise annotations, which are usually difficult, expensive, and slow to obtain. In comparison, massive unlabeled 3D CT volumes are usually easily accessible. Current mainstream works to address the semi-supervised biomedical image segmentation problem are mostly graph-based. By contrast, deep network based semi-supervised learning methods have not drawn much attention in this field. In this work, we propose Deep Multi-Planar Co-Training (DMPCT), whose contributions can be divided into two folds: 1) The deep model is learned in a co-training style which can mine consensus information from multiple planes like the sagittal, coronal, and axial planes; 2) Multi-planar fusion is applied to generate more reliable pseudo-labels, which alleviates the errors occurring in the pseudo-labels and thus can help to train better segmentation networks. Experiments are done on our newly collected large dataset with 100 unlabeled cases as well as 210 labeled cases where 16 anatomical structures are manually annotated by four radiologists and confirmed by a senior expert. The results suggest that DMPCT significantly outperforms the fully supervised method by more than 4% especially when only a small set of annotations is used.
Delft University of Technology（代尔夫特理工大学）；CycloMedia Technology（CycloMedia科技公司）
We introduce a novel deep learning-based framework to interpret 3D urban scenes represented as textured meshes. Based on the observation that object boundaries typically align with the boundaries of planar regions, our framework achieves semantic segmentation in two steps: planarity-sensible over-segmentation followed by semantic classification. The over-segmentation step generates an initial set of mesh segments that capture the planar and non-planar regions of urban scenes. In the subsequent classification step, we construct a graph that encodes the geometric and photometric features of the …
Ludwig Maximilians University（路德维希-马克西米利安大学）；Technical University Munich（慕尼黑工业大学）
The wide range of research in deep learning-based medical image segmentation pushed the boundaries in a multitude of applications. A clinically relevant problem that received less attention is the handling of scans with irregular anatomy, e.g., after organ resection. State-of-the-art segmentation models often lead to organ hallucinations, i.e., false-positive predictions of organs, which cannot be alleviated by oversampling or post-processing. Motivated by the increasing need to develop robust deep learning models, we propose HALOS for abdominal organ segmentation in MR images that handles cas…
Image stitching for two images without a global transformation between them is notoriously difficult. In this paper, noticing the importance of planar structure under perspective geometry, we propose a new image stitching method which stitches images by allowing for the alignment of a set of matched dominant planar regions. Clearly different from previous methods resorting to plane segmentation, the key to our approach is to utilize rich semantic information directly from RGB images to extract planar image regions with a deep Convolutional Neural Network (CNN). We specifically design a new mod…
Experian（益博睿）；University of California Irvine（加州大学欧文分校）
We study the problem of hierarchical clustering on planar graphs. We formulate this in terms of an LP relaxation of ultrametric rounding. To solve this LP efficiently we introduce a dual cutting plane scheme that uses minimum cost perfect matching as a subroutine in order to efficiently explore the space of planar partitions. We apply our algorithm to the problem of hierarchical image segmentation.
SelfMedHPM: Self Pre-training With Hard Patches Mining Masked Autoencoders For Medical Image Segmentation
1 Department of Computer Science；Engineering, Nanjing University of Aeronautics；\ , Nanjing, China 2 School of Biomedical Engineering；the Institute of Medical Robotics, Shanghai JiaoTong University, Shanghai, 200240, China
We study the problem of multicut segmentation. We introduce modified versions of the Semi-PlanarCC based on bounding Lagrange multipliers. We apply our work to natural image segmentation.
Northwestern Polytechnical University（西北工业大学）；The University of Adelaide（阿德莱德大学）；Alibaba DAMO Academy（阿里巴巴达摩院）；Zhejiang University（浙江大学）
Medical image benchmarks for the segmentation of organs and tumors suffer from the partially labeling issue due to its intensive cost of labor and expertise. Current mainstream approaches follow the practice of one network solving one task. With this pipeline, not only the performance is limited by the typically small dataset of a single task, but also the computation cost linearly increases with the number of tasks. To address this, we propose a Transformer based dynamic on-demand network (TransDoDNet) that learns to segment organs and tumors on multiple partially labeled datasets. Specifical…
Semantic segmentation is an import task in the medical field to identify the exact extent and orientation of significant structures like organs and pathology. Deep neural networks can perform this task well by leveraging the information from a large well-labeled data-set. This paper aims to present a method that mitigates the necessity of an extensive well-labeled data-set. This method also addresses semi-supervision by enabling segmentation based on bounding box annotations, avoiding the need for full pixel-level annotations. The network presented consists of a single U-Net based unbranched a…
Seoul National University（首尔国立大学）；Soongsil University（崇实大学）
Recent works in medical image segmentation have actively explored various deep learning architectures or objective functions to encode high-level features from volumetric data owing to limited image annotations. However, most existing approaches tend to ignore cross-volume global context and define context relations in the decision space. In this work, we propose a novel voxel-level Siamese representation learning method for abdominal multi-organ segmentation to improve representation space. The proposed method enforces voxel-wise feature relations in the representation space for leveraging li…
ThreshGuide: Class-Aware Labeled-Guided Thresholding for Semi-Supervised 3D Abdominal Multi-Organ Segmentation
School of Intelligent Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences（中国科学院大学杭州高等研究院智能科学与技术学院）
Shortage of fully annotated datasets has been a limiting factor in developing deep learning based image segmentation algorithms and the problem becomes more pronounced in multi-organ segmentation. In this paper, we propose a unified training strategy that enables a novel multi-scale deep neural network to be trained on multiple partially labeled datasets for multi-organ segmentation. In addition, a new network architecture for multi-scale feature abstraction is proposed to integrate pyramid input and feature analysis into a U-shape pyramid structure. To bridge the semantic gap caused by direct…
We describe a new optimization scheme for finding high-quality correlation clusterings in planar graphs that uses weighted perfect matching as a subroutine. Our method provides lower-bounds on the energy of the optimal correlation clustering that are typically fast to compute and tight in practice. We demonstrate our algorithm on the problem of image segmentation where this approach outperforms existing global optimization techniques in minimizing the objective and is competitive with the state of the art in producing high-quality segmentations.
The Chinese University of Hong Kong（香港中文大学）；The First Hospital of Jilin University（吉林大学第一医院）
Despite the remarkable success on medical image analysis with deep learning, it is still under exploration regarding how to rapidly transfer AI models from one dataset to another for clinical applications. This paper presents a novel and generic human-in-the-loop scheme for efficiently transferring a segmentation model from a small-scale labelled dataset to a larger-scale unlabelled dataset for multi-organ segmentation in CT. To achieve this, we propose to use an igniter network which can learn from a small-scale labelled dataset and generate coarse annotations to start the process of human-ma…
Nagoya University（名古屋大学）；Aichi Cancer Center（爱知县癌症中心）；National Institute of Informatics（国立信息学研究所）
Recent advances in deep learning, like 3D fully convolutional networks (FCNs), have improved the state-of-the-art in dense semantic segmentation of medical images. However, most network architectures require severely downsampling or cropping the images to meet the memory limitations of today's GPU cards while still considering enough context in the images for accurate segmentation. In this work, we propose a novel approach that utilizes auto-context to perform semantic segmentation at higher resolutions in a multi-scale pyramid of stacked 3D FCNs. We train and validate our models on a dataset …
Large-scale EM Benchmark for Multi-Organelle Instance Segmentation in the Wild
Guangzhou Institutes of Biomedicine and Health（广州生物医学研究院）；South China University of Technology（华南理工大学）；Center for Infectious Disease Research（传染病研究中心）；Westlake University（西湖大学）；RIKEN（日本理化学研究所）
Northwestern Polytechnical University（西北工业大学）；The University of Adelaide（阿德莱德大学）
Due to the intensive cost of labor and expertise in annotating 3D medical images at a voxel level, most benchmark datasets are equipped with the annotations of only one type of organs and/or tumors, resulting in the so-called partially labeling issue. To address this, we propose a dynamic on-demand network (DoDNet) that learns to segment multiple organs and tumors on partially labeled datasets. DoDNet consists of a shared encoder-decoder architecture, a task encoding module, a controller for generating dynamic convolution filters, and a single but dynamic segmentation head. The information of …
With the development of image segmentation in computer vision, biomedical image segmentation have achieved remarkable progress on brain tumor segmentation and Organ At Risk (OAR) segmentation. However, most of the research only uses single modality such as Computed Tomography (CT) scans while in real world scenario doctors often use multiple modalities to get more accurate result. To better leverage different modalities, we have collected a large dataset consists of 136 cases with CT and MR images which diagnosed with nasopharyngeal cancer. In this paper, we propose to use Generative Adversari…
Northwestern University（西北大学）；University of Chicago（芝加哥大学）
Accurate segmentation of organs-at-risks (OARs) is a precursor for optimizing radiation therapy planning. Existing deep learning-based multi-scale fusion architectures have demonstrated a tremendous capacity for 2D medical image segmentation. The key to their success is aggregating global context and maintaining high resolution representations. However, when translated into 3D segmentation problems, existing multi-scale fusion architectures might underperform due to their heavy computation overhead and substantial data diet. To address this issue, we propose a new OAR segmentation framework, c…
Swinburne University of Technology（斯威本科技大学）；Victoria University（维多利亚大学）；Kyung Hee University（庆熙大学）
Quantitative assessment of the abdominal region from clinically acquired CT scans requires the simultaneous segmentation of abdominal organs. Thanks to the availability of high-performance computational resources, deep learning-based methods have resulted in state-of-the-art performance for the segmentation of 3D abdominal CT scans. However, the complex characterization of organs with fuzzy boundaries prevents the deep learning methods from accurately segmenting these anatomical organs. Specifically, the voxels on the boundary of organs are more vulnerable to misprediction due to the highly-va…
Emory University（埃默里大学）；Winship Cancer Institute（温希普癌症研究所）
This paper presents a review of deep learning (DL) in multi-organ segmentation. We summarized the latest DL-based methods for medical image segmentation and applications. These methods were classified into six categories according to their network design. For each category, we listed the surveyed works, highlighted important contributions and identified specific challenges. Following the detailed review of each category, we briefly discussed its achievements, shortcomings and future potentials. We provided a comprehensive comparison among DL-based methods for thoracic and head & neck multiorga…
Accurate segmentation of prostate and surrounding organs at risk is important for prostate cancer radiotherapy treatment planning. We present a fully automated workflow for male pelvic CT image segmentation using deep learning. The architecture consists of a 2D localization network followed by a 3D segmentation network for volumetric segmentation of prostate, bladder, rectum, and femoral heads. We used a multi-channel 2D U-Net followed by a 3D U-Net with encoding arm modified with aggregated residual networks, known as ResNeXt. The models were trained and tested on a pelvic CT image dataset co…
University of Central Florida（中佛罗里达大学）；KnowledgeVis LLC（知识可视化有限责任公司）；Orlando Health（奥兰多健康中心）；Northwestern University（西北大学）
Organ at risk (OAR) segmentation is a crucial step for treatment planning and outcome determination in radiotherapy treatments of cancer patients. Several deep learning based segmentation algorithms have been developed in recent years, however, U-Net remains the de facto algorithm designed specifically for biomedical image segmentation and has spawned many variants with known weaknesses. In this study, our goal is to present simple architectural changes in U-Net to improve its accuracy and generalization properties. Unlike many other available studies evaluating their algorithms on single cent…
Segmentation of organs of interest in 3D medical images is necessary for accurate diagnosis and longitudinal studies. Though recent advances using deep learning have shown success for many segmentation tasks, large datasets are required for high performance and the annotation process is both time consuming and labor intensive. In this paper, we propose a 3D few shot segmentation framework for accurate organ segmentation using limited training samples of the target organ annotation. To achieve this, a U-Net like network is designed to predict segmentation by learning the relationship between 2D…
Osaka University Graduate School of Medicine（大阪大学医学研究生院）
Multi-organ segmentation enables organ evaluation, accounts the relationship between multiple organs, and facilitates accurate diagnosis and treatment decisions. However, only few models can perform segmentation accurately because of the lack of datasets and computational resources. On AMOS2022 challenge, which is a large-scale, clinical, and diverse abdominal multiorgan segmentation benchmark, we trained a 3D-UNet model with large batch and patch sizes using multi-GPU distributed training. Segmentation performance tended to increase for models with large batch and patch sizes compared with th…
School of Computer Science and Technology, Zhejiang Normal University（浙江师范大学计算机科学与技术学院）；Metaverse and Artificial Intelligence Institute of Wenzhou University（温州大学元宇宙与人工智能研究院）
Multi-organ segmentation is a critical task in computer-aided diagnosis. While recent deep learning methods have achieved remarkable success in image segmentation, huge variations in organ size and shape challenge their effectiveness in multi-organ segmentation. To address these challenges, we propose a Spatial Prior-Guided Cross Dual Encoder Network (SPG-CDENet), a novel two-stage segmentation paradigm designed to improve multi-organ segmentation accuracy. Our SPG-CDENet consists of two key components: a spatial prior network and a cross dual encoder network. The prior network generates coars…
DFKI - German Research Center for Artificial Intelligence（德国人工智能研究中心）
Instance segmentation of planar regions in indoor scenes benefits visual SLAM and other applications such as augmented reality (AR) where scene understanding is required. Existing methods built upon two-stage frameworks show satisfactory accuracy but are limited by low frame rates. In this work, we propose a real-time deep neural architecture that estimates piece-wise planar regions from a single RGB image. Our model employs a variant of a fast single-stage CNN architecture to segment plane instances. Considering the particularity of the target detected, we propose Fast Feature Non-maximum Sup…
Pelvic floor MRI segmentation based on semi-supervised deep learning
Institute of Medical Technology, Peking University Health Science Center, Peking University（北京大学医学部医学技术研究院，北京大学）；Biomedical Engineering Department, Peking University（北京大学生物医学工程系）；University of Michigan-Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University（上海交通大学密西根学院）；School of Electrical and Electronic Engineering, Nanyang Technological University（南洋理工大学电子与电气工程学院）；Department of Mechanical Engineering, University of Michigan（密歇根大学机械工程系）；Department of Obstetrics and Gynecology, University of Michigan（密歇根大学妇产科）
Technical University of Munich（慕尼黑工业大学）；Ulm University（乌尔姆大学）
The lack of sufficient annotated image data is a common issue in medical image segmentation. For some organs and densities, the annotation may be scarce, leading to poor model training convergence, while other organs have plenty of annotated data. In this work, we present MetaMedSeg, a gradient-based meta-learning algorithm that redefines the meta-learning task for the volumetric medical data with the goal to capture the variety between the slices. We also explore different weighting schemes for gradients aggregation, arguing that different tasks might have different complexity, and hence, con…
Southeast University（东南大学）；Swinburne University of Technology（斯威本科技大学）；Communication University of China（中国传媒大学）
Precise segmentation of organs and tumors plays a crucial role in clinical applications. It is a challenging task due to the irregular shapes and various sizes of organs and tumors as well as the significant class imbalance between the anatomy of interest (AOI) and the background region. In addition, in most situation tumors and normal organs often overlap in medical images, but current approaches fail to delineate both tumors and organs accurately. To tackle such challenges, we propose a position-guided deformable UNet, namely PGD-UNet, which exploits the spatial deformation capabilities of d…
Gottfried Schatz Research Center: Biophysics（戈特弗里德·沙茨研究中心：生物物理部）；Institute of Computer Graphics and Vision（计算机图形与视觉研究所）；Medical University of Graz（格拉茨医科大学）；Graz University of Technology（格拉茨技术大学）
Even though many semantic segmentation methods exist that are able to perform well on many medical datasets, often, they are not designed for direct use in clinical practice. The two main concerns are generalization to unseen data with a different visual appearance, e.g., images acquired using a different scanner, and efficiency in terms of computation time and required Graphics Processing Unit (GPU) memory. In this work, we employ a multi-organ segmentation model based on the SpatialConfiguration-Net (SCN), which integrates prior knowledge of the spatial configuration among the labelled organ…
Automated segmentation can assist radiotherapy treatment planning by saving manual contouring efforts and reducing intra-observer and inter-observer variations. The recent development of deep learning approaches has revoluted medical data processing, including semantic segmentation, by dramatically improving performance. However, training effective deep learning models usually require a large amount of high-quality labeled data, which are often costly to collect. We developed a novel semi-supervised adversarial deep learning approach for 3D pelvic CT image semantic segmentation. Unlike supervi…
Washington University（华盛顿大学）；Washington University School of Medicine（华盛顿大学医学院）
Purpose: The research is to develop a novel CNN-based adversarial deep learning method to improve and expedite the multi-organ semantic segmentation of CT images, and to generate accurate contours on pelvic CT images. Methods: Planning CT and structure datasets for 120 patients with intact prostate cancer were retrospectively selected and divided for 10-fold cross-validation. The proposed adversarial multi-residual multi-scale pooling Markov Random Field (MRF) enhanced network (ARPM-net) implements an adversarial training scheme. A segmentation network and a discriminator network were trained …
Indian Institute of Technology Delhi（印度理工学院德里分校）；Chennai Mathematical Institute（金奈数学研究所）
Despite the tremendous progress made by deep learning models in image semantic segmentation, they typically require large annotated examples, and increasing attention is being diverted to problem settings like Few-Shot Learning (FSL) where only a small amount of annotation is needed for generalisation to novel classes. This is especially seen in medical domains where dense pixel-level annotations are expensive to obtain. In this paper, we propose Regularized Prototypical Neural Ordinary Differential Equation (R-PNODE), a method that leverages intrinsic properties of Neural-ODEs, assisted and e…
Vanderbilt University（范德堡大学）；Sigma Technologies（12西格玛技术公司）；Vanderbilt University Medical Center（范德堡大学医学中心）
Human in-the-loop quality assurance (QA) is typically performed after medical image segmentation to ensure that the systems are performing as intended, as well as identifying and excluding outliers. By performing QA on large-scale, previously unlabeled testing data, categorical QA scores can be generatedIn this paper, we propose a semi-supervised multi-organ segmentation deep neural network consisting of a traditional segmentation model generator and a QA involved discriminator. A large-scale dataset of 2027 volumes are used to train the generator, whose 2-D montage images and segmentation mas…
This paper deals with offline handwriting signature verification.We propose a planar neuronal model of signature image. Planarmodelsare generally based on delimiting homogenous zones ofimages; we propose in this paper an automatic segmentationapproach into bands of signature images. Signature image ismodeled by a planar neuronal model with horizontal secondarymodels and a verticalprincipal model. The proposed methodhas been tested on two databases. The first is the one we havecollected; it includes 6000 signaturescorresponding to 60writers. The second is the public GPDS-300 database including1…
Tailored Multi-Organ Segmentation with Model Adaptation and Ensemble
Zhejiang University（浙江大学）；Suzhou Institute for Advanced Research, University of Science and Technology of China（中国科学技术大学苏州高等研究院）；Ritsumeikan University（立命馆大学）；University of Science and Technology of China（中国科学技术大学）
Automatic segmentation of abdomen organs using medical imaging has many potential applications in clinical workflows. Recently, the state-of-the-art performance for organ segmentation has been achieved by deep learning models, i.e., convolutional neural network (CNN). However, it is challenging to train the conventional CNN-based segmentation models that aware of the shape and topology of organs. In this work, we tackle this problem by introducing a novel end-to-end shape learning architecture -- organ point-network. It takes deep learning features as inputs and generates organ shape represent…
Cooperative Medianet Innovation Center, Shanghai Jiao Tong University（上海交通大学媒体网络协同创新中心）
Annotating multiple organs in 3D medical images is time-consuming and costly. Meanwhile, there exist many single-organ datasets with one specific organ annotated. This paper investigates how to learn a multi-organ segmentation model leveraging a set of binary-labeled datasets. A novel Multi-teacher Single-student Knowledge Distillation (MS-KD) framework is proposed, where the teacher models are pre-trained single-organ segmentation networks, and the student model is a multi-organ segmentation network. Considering that each teacher focuses on different organs, a region-based supervision method,…
Beijing UCAS Space Technology Co., Ltd.（北京国科大空间技术有限公司）；University of Science and Technology of China（中国科学技术大学）；Institute of Computing Technology, CAS（中国科学院计算技术研究所）
Objective and Impact Statement: Accurate organ segmentation is critical for many clinical applications at different clinical sites, which may have their specific application requirements that concern different organs. Introduction: However, learning high-quality, site-specific organ segmentation models is challenging as it often needs on-site curation of a large number of annotated images. Security concerns further complicate the matter. Methods: The paper aims to tackle these challenges via a two-phase aggregation-then-adaptation approach. The first phase of federated aggregation learns a sin…
InferLink Corporation（InferLink公司）；Fred Hutch Cancer Research Center（弗雷德·哈钦森癌症研究中心）
The analysis of animal cross section images, such as cross sections of laboratory mice, is critical in assessing the effect of experimental drugs such as the biodistribution of candidate compounds in preclinical drug development stage. Tissue distribution of radiolabeled candidate therapeutic compounds can be quantified using techniques like Quantitative Whole-Body Autoradiography (QWBA).QWBA relies, among other aspects, on the accurate segmentation or identification of key organs of interest in the animal cross section image such as the brain, spine, heart, liver and others. We present a deep…
Deep Mutual Learning among Partially Labeled Datasets for Multi-Organ Segmentation
Digital Medical Research Center, School of Basic Medical Science, Fudan University（复旦大学基础医学院数字医学研究中心）；Shanghai Key Lab of Medical Image Computing and Computer Assisted Intervention（上海市医学影像计算与计算机辅助介入重点实验室）
The University of Hong Kong（香港大学）；Tencent（腾讯）；Huazhong University of Science and Technology（华中科技大学）
Learning by imitation is one of the most significant abilities of human beings and plays a vital role in human's computational neural system. In medical image analysis, given several exemplars (anchors), experienced radiologist has the ability to delineate unfamiliar organs by imitating the reasoning process learned from existing types of organs. Inspired by this observation, we propose OrganNet which learns a generalized organ concept from a set of annotated organ classes and then transfer this concept to unseen classes. In this paper, we show that such process can be integrated into the one-…
Technical University of Munich（慕尼黑工业大学）；Klinikum rechts der Isar（慕尼黑 Rechts der Isar 医院）；University of Zurich（苏黎世大学）
Automatic localization and segmentation of organs-at-risk (OAR) in CT are essential pre-processing steps in medical image analysis tasks, such as radiation therapy planning. For instance, the segmentation of OAR surrounding tumors enables the maximization of radiation to the tumor area without compromising the healthy tissues. However, the current medical workflow requires manual delineation of OAR, which is prone to errors and is annotator-dependent. In this work, we aim to introduce a unified 3D pipeline for OAR localization-segmentation rather than novel localization or segmentation archite…
