Automatic liver segmentation plays an important role in computer-aided diagnosis and treatment. Manual segmentation of organs is a difficult and tedious task and so prone to human errors. In this paper, we propose an adaptive 3D region growing with subject-specific conditions. For this aim we use the intensity distribution of most probable voxels in prior map along with location prior. We also incorporate the boundary of target organs to restrict the region growing. In order to obtain strong edges and high contrast, we propose an effective contrast enhancement algorithm to facilitate more accurate segmentation. In this paper, 92.56% Dice score is achieved. We compare our method with the method of hard thresholding on Deeds prior map and also with the majority voting on Deeds registration with 13 organs.
Seoul National University(首尔国立大学);Soong-sil University(崇实大学)
Accurate image segmentation of the liver is a challenging problem owing to its large shape variability and unclear boundaries. Although the applications of fully convolutional neural networks (CNNs) have shown groundbreaking results, limited studies have focused on the performance of generalization. In this study, we introduce a CNN for liver segmentation on abdominal computed tomography (CT) images that shows high generalization performance and accuracy. To improve the generalization performance, we initially propose an auto-context algorithm in a single CNN. The proposed auto-context neural …
Isfahan University of Technology(伊斯法罕理工大学);University of Michigan(密歇根大学)
The need for CT scan analysis is growing for pre-diagnosis and therapy of abdominal organs. Automatic organ segmentation of abdominal CT scan can help radiologists analyze the scans faster and segment organ images with fewer errors. However, existing methods are not efficient enough to perform the segmentation process for victims of accidents and emergencies situations. In this paper we propose an efficient liver segmentation with our 3D to 2D fully connected network (3D-2D-FCN). The segmented mask is enhanced by means of conditional random field on the organ's border. Consequently, we segment…
Accurate liver and lesion segmentation from computed tomography (CT) images are highly demanded in clinical practice for assisting the diagnosis and assessment of hepatic tumor disease. However, automatic liver and lesion segmentation from contrast-enhanced CT volumes is extremely challenging due to the diversity in contrast, resolution, and quality of images. Previous methods based on UNet for 2D slice-by-slice or 3D volume-by-volume segmentation either lack sufficient spatial contexts or suffer from high GPU computational cost, which limits the performance. To tackle these issues, we propose…
Seoul National University(首尔国立大学);Soong-sil University(崇实大学)
Objective: Herein, a neural network-based liver segmentation algorithm is proposed, and its performance was evaluated using abdominal computed tomography (CT) images. Methods: A fully convolutional network was developed to overcome the volumetric image segmentation problem. To guide a neural network to accurately delineate a target liver object, the network was deeply supervised by applying the adaptive self-supervision scheme to derive the essential contour, which acted as a complement with the global shape. The discriminative contour, shape, and deep features were internally merged for the s…
Objective : Abdominal anatomy segmentation is crucial for numerous applications from computer-assisted diagnosis to image-guided surgery. In this context, we address fully-automated multi-organ segmentation from abdominal CT and MR images using deep learning. Methods: The proposed model extends standard conditional generative adversarial networks. Additionally to the discriminator which enforces the model to create realistic organ delineations, it embeds cascaded partially pre-trained convolutional encoder-decoders as generator. Encoder fine-tuning from a large amount of non-medical images all…
Nagoya University(名古屋大学);German Cancer Research Center (DKFZ)(德国癌症研究中心);University Hospital Erlangen(埃尔朗根大学医院);Paracelsus Medical University(帕拉塞尔苏斯医科大学)
Automatic multi-organ segmentation of the dual energy computed tomography (DECT) data can be beneficial for biomedical research and clinical applications. However, it is a challenging task. Recent advances in deep learning showed the feasibility to use 3-D fully convolutional networks (FCN) for voxel-wise dense predictions in single energy computed tomography (SECT). In this paper, we proposed a 3D FCN based method for automatic multi-organ segmentation in DECT. The work was based on a cascaded FCN and a general model for the major organs trained on a large set of SECT data. We preprocessed th…
Colorectal liver metastasis is one of most aggressive liver malignancies. While the definition of lesion type based on CT images determines the diagnosis and therapeutic strategy, the discrimination between cancerous and non-cancerous lesions are critical and requires highly skilled expertise, experience and time. In the present work we introduce an end-to-end deep learning approach to assist in the discrimination between liver metastases from colorectal cancer and benign cysts in abdominal CT images of the liver. Our approach incorporates the efficient feature extraction of InceptionV3 combin…
National Institutes of Health Clinical Center(美国国立卫生研究院临床中心)
Organ segmentation is a prerequisite for a computer-aided diagnosis (CAD) system to detect pathologies and perform quantitative analysis. For anatomically high-variability abdominal organs such as the pancreas, previous segmentation works report low accuracies when comparing to organs like the heart or liver. In this paper, a fully-automated bottom-up method is presented for pancreas segmentation, using abdominal computed tomography (CT) scans. The method is based on a hierarchical two-tiered information propagation by classifying image patches. It labels superpixels as pancreas or not via poo…
Automatic segmentation of liver and its tumors is an essential step for extracting quantitative imaging biomarkers for accurate tumor detection, diagnosis, prognosis and assessment of tumor response to treatment. MICCAI 2017 Liver Tumor Segmentation Challenge (LiTS) provides a common platform for comparing different automatic algorithms on contrast-enhanced abdominal CT images in tasks including 1) liver segmentation, 2) liver tumor segmentation, and 3) tumor burden estimation. We participate this challenge by developing a hierarchical framework based on deep fully convolutional-deconvolutiona…
Technische Universität München(慕尼黑工业大学);LMU Hospital Grosshadern(LMU格罗斯哈德恩医院)
Automatic segmentation of the liver and its lesion is an important step towards deriving quantitative biomarkers for accurate clinical diagnosis and computer-aided decision support systems. This paper presents a method to automatically segment liver and lesions in CT abdomen images using cascaded fully convolutional neural networks (CFCNs) and dense 3D conditional random fields (CRFs). We train and cascade two FCNs for a combined segmentation of the liver and its lesions. In the first step, we train a FCN to segment the liver as ROI input for a second FCN. The second FCN solely segments lesion…
MSWAL: 3D Multi-class Segmentation of Whole Abdominal Lesions Dataset
Shanghai AI Lab(上海人工智能实验室);University of Liverpool(利物浦大学);Columbia university(哥伦比亚大学);Monash University(墨尔本大学);Xi'an Jiaotong-Liverpool University(西安交通大学利物浦大学);MBZUAI(穆斯林人工智能研究所);People's Hospital of Gong'an County(公安县人民医院)
本文提出首个 3D 全腹部病变多类分割数据集 MSWAL,覆盖七类常见病变,并提出 Inception nnU-Net 框架,在分割性能上显著优于现有方法。
AbdomenGen: Sequential Volume-Conditioned Diffusion Framework for Abdominal Anatomy Generation
Center for Virtual Imaging Trials, Dept. of Radiology, Duke University School of Medicine(虚拟成像试验中心,放射科,杜克大学医学部);Dept. of Electrical and Computer Engineering, Pratt School of Engineering, Duke University(电气与计算机工程系,普拉特工程学院,杜克大学);Dept. of Physics, Trinity School of Arts and Sciences, Duke University(物理系,特里尼蒂艺术与科学学院,杜克大学)
AbdomenGen提出了一种序列体积条件扩散框架,通过Volume Control Scalar实现可控的腹部解剖生成,实现了高几何保真度和多器官解耦调节。
Deformable registration of two-dimensional/three-dimensional (2D/3D) images of abdominal organs is a complicated task because the abdominal organs deform significantly and their contours are not detected in two-dimensional X-ray images. We propose a supervised deep learning framework that achieves 2D/3D deformable image registration between 3D volumes and single-viewpoint 2D projected images. The proposed method learns the translation from the target 2D projection images and the initial 3D volume to 3D displacement fields. In experiments, we registered 3D-computed tomography (CT) volumes to di…
Transfer learning and joint learning approaches are extensively used to improve the performance of Convolutional Neural Networks (CNNs). In medical imaging applications in which the target dataset is typically very small, transfer learning improves feature learning while joint learning has shown effectiveness in improving the network's generalization and robustness. In this work, we study the combination of these two approaches for the problem of liver lesion segmentation and classification. For this purpose, 332 abdominal CT slices containing lesion segmentation and classification of three le…
Applications of ultrasound images have expanded from fetal imaging to abdominal and cardiac diagnosis. Liver-being the largest gland in the body and responsible for metabolic activities requires to be to be diagnosed and therefore subject to utmost injury. Although, ultrasound imaging has developed into three and four dimensions providing higher amount of information; it requires highly trained medical staff due to the image complexity and dimensions it contain. Since 2D ultrasound images are still considered to be the basis of clinical treatments,computer aided automated liver diagnosis is ve…
Vanderbilt University(范德堡大学);Vanderbilt University Medical Center(范德堡大学医学中心);Wake Forest School of Medicine(维克森林大学医学院)
Manually tracing regions of interest (ROIs) within the liver is the de facto standard method for measuring liver attenuation on computed tomography (CT) in diagnosing nonalcoholic fatty liver disease (NAFLD). However, manual tracing is resource intensive. To address these limitations and to expand the availability of a quantitative CT measure of hepatic steatosis, we propose the automatic liver attenuation ROI-based measurement (ALARM) method for automated liver attenuation estimation. The ALARM method consists of two major stages: (1) deep convolutional neural network (DCNN)-based liver segme…
Primary tumors have a high likelihood of developing metastases in the liver and early detection of these metastases is crucial for patient outcome. We propose a method based on convolutional neural networks (CNN) to detect liver metastases. First, the liver was automatically segmented using the six phases of abdominal dynamic contrast enhanced (DCE) MR images. Next, DCE-MR and diffusion weighted (DW) MR images are used for metastases detection within the liver mask. The liver segmentations have a median Dice similarity coefficient of 0.95 compared with manual annotations. The metastases detect…
The University of Manchester(曼彻斯特大学);The Christie NHS Foundation Trust(克里斯蒂NHS基金会信托)
Abdominal organ segmentation is a difficult and time-consuming task. To reduce the burden on clinical experts, fully-automated methods are highly desirable. Current approaches are dominated by Convolutional Neural Networks (CNNs) however the computational requirements and the need for large data sets limit their application in practice. By implementing a small and efficient custom 3D CNN, compiling the trained model and optimizing the computational graph: our approach produces high accuracy segmentations (Dice Similarity Coefficient (%): Liver: 97.3$\pm$1.3, Kidneys: 94.8$\pm$3.6, Spleen: 96.4…
First Affiliated Hospital of Zhejiang University(浙江大学医学院附属第一医院);Zhejiang University(浙江大学)
Purpose Segmentation of the liver from abdominal computed tomography (CT) image is an essential step in some computer assisted clinical interventions, such as surgery planning for living donor liver transplant (LDLT), radiotherapy and volume measurement. In this work, we develop a deep learning algorithm with graph cut refinement to automatically segment liver in CT scans. Methods The proposed method consists of two main steps: (i) simultaneously liver detection and probabilistic segmentation using 3D convolutional neural networks (CNNs); (ii) accuracy refinement of initial segmentation with g…
A two-step concept for 3D segmentation on 5 abdominal organs inside volumetric CT images is presented. First each relevant organ's volume of interest is extracted as bounding box. The extracted volume acts as input for a second stage, wherein two compared U-Nets with different architectural dimensions re-construct an organ segmentation as label mask. In this work, we focus on comparing 2D U-Nets vs. 3D U-Net counterparts. Our initial results indicate Dice improvements of about 6\% at maximum. In this study to our surprise, liver and kidneys for instance were tackled significantly better using …
MRISegmentator-Abdomen: A Fully Automated Multi-Organ and Structure Segmentation Tool for T1-weighted Abdominal MRI
Radiology and Imaging Sciences(放射学与影像科学);National Institutes of Health Clinical Center(国家卫生研究院临床中心);Walter Reed National Military Medical Center(沃尔特·里德国家军事医学中心);Biostatistics and Clinical Epidemiology Services(生物统计与临床流行病学服务)
Nanjing University of Science and Technology(南京理工大学);Institute of Computing Technology, Chinese Academy of Sciences(中国科学院计算技术研究所);University of Chinese Academy of Sciences(中国科学院大学);Lenovo Research(联想研究院);Nanjing University of Information Science and Technology(南京信息工程大学);Shenzhen Haichuang Medical CO., LTD.(深圳海创医疗有限公司);Jiangsu University of Technology(江苏理工学院);Beihang University(北京航空航天大学);Beijing Infervision Technology CO. LTD.(北京推想科技有限公司);Tianjin University of Technology(天津理工大学);Norwegian University of Science and Technology(挪威科技大学);Nanjing University(南京大学);Suzhou LungCare Medical Technology Co., Ltd(苏州朗润医疗科技有限公司);King Abdullah University of Science and Technology(阿卜杜拉国王科技大学)
With the unprecedented developments in deep learning, automatic segmentation of main abdominal organs seems to be a solved problem as state-of-the-art (SOTA) methods have achieved comparable results with inter-rater variability on many benchmark datasets. However, most of the existing abdominal datasets only contain single-center, single-phase, single-vendor, or single-disease cases, and it is unclear whether the excellent performance can generalize on diverse datasets. This paper presents a large and diverse abdominal CT organ segmentation dataset, termed AbdomenCT-1K, with more than 1000 (1K…
Technical University of Munich(慕尼黑工业大学);LMU Hospital Grosshadern(路德维希-马克西米利安-慕尼黑大学格罗斯哈德恩医院)
Automatic segmentation of the liver and hepatic lesions is an important step towards deriving quantitative biomarkers for accurate clinical diagnosis and computer-aided decision support systems. This paper presents a method to automatically segment liver and lesions in CT and MRI abdomen images using cascaded fully convolutional neural networks (CFCNs) enabling the segmentation of a large-scale medical trial or quantitative image analysis. We train and cascade two FCNs for a combined segmentation of the liver and its lesions. In the first step, we train a FCN to segment the liver as ROI input …
Image Sciences Institute, University Medical Center Utrecht(乌得勒支大学医学中心图像科学研究所);Department of Biomedical Engineering, Eindhoven University of Technology(埃因霍温理工大学生物医学工程系)
Despite the successes of deep learning techniques at detecting objects in medical images, false positive detections occur which may hinder an accurate diagnosis. We propose a technique to reduce false positive detections made by a neural network using an SVM classifier trained with features derived from the uncertainty map of the neural network prediction. We demonstrate the effectiveness of this method for the detection of liver lesions on a dataset of abdominal MR images. We find that the use of a dropout rate of 0.5 produces the least number of false positives in the neural network predicti…
University of Westminster(威斯敏斯特大学);Calico Life Sciences LLC(Calico生命科学有限责任公司)
An end-to-end image analysis pipeline is presented for the abdominal MRI protocol used in the UK Biobank on the first 38,971 participants. Emphasis is on the processing steps necessary to ensure a high-level of data quality and consistency is produced in order to prepare the datasets for downstream quantitative analysis, such as segmentation and parameter estimation. Quality control procedures have been incorporated to detect and, where possible, correct issues in the raw data. Detection of fat-water swaps in the Dixon series is performed by a deep learning model and corrected automatically. B…
Accurate and robust abdominal multi-organ segmentation from CT imaging of different modalities is a challenging task due to complex inter- and intra-organ shape and appearance variations among abdominal organs. In this paper, we propose a probabilistic multi-organ segmentation network with hierarchical spatial-wise feature modulation to capture flexible organ semantic variants and inject the learnt variants into different scales of feature maps for guiding segmentation. More specifically, we design an input decomposition module via a conditional variational auto-encoder to learn organ-specific…
Hunan University of Technology and Business(湖南工商大学);Utah State University(犹他州立大学);University of Idaho(爱达荷大学)
Liver segmentation from abdominal CT images is an essential step for liver cancer computer-aided diagnosis and surgical planning. However, both the accuracy and robustness of existing liver segmentation methods cannot meet the requirements of clinical applications. In particular, for the common clinical cases where the liver tissue contains major pathology, current segmentation methods show poor performance. In this paper, we propose a novel low-rank tensor decomposition (LRTD) based multi-atlas segmentation (MAS) framework that achieves accurate and robust pathological liver segmentation of C…
Motion-robust 2D Radial Turbo Spin Echo (RADTSE) pulse sequence can provide a high-resolution composite image, T2-weighted images at multiple echo times (TEs), and a quantitative T2 map, all from a single k-space acquisition. In this work, we use a deep-learning convolutional neural network (CNN) for the segmentation of liver in abdominal RADTSE images. A modified UNET architecture with generalized dice loss objective function was implemented. Three 2D CNNs were trained, one for each image type obtained from the RADTSE sequence. On evaluating the performance of the CNNs on the validation set, …
Parameter-Efficient Fine-Tuning of Foundation Models for Liver Tumor Segmentation in CT
University Health Network(大学健康网络);Memorial Sloan Kettering Cancer Center(纪念斯隆凯特琳癌症中心);University of Alberta(阿尔伯塔大学);Alberta Machine Intelligence Institute(阿尔伯塔机器智能研究所);Islamic Azad University(伊斯兰阿扎德大学)
PLUS: Plug-and-Play Enhanced Liver Lesion Diagnosis Model on Non-Contrast CT Scans
School of Biomedical Engineering, Tsinghua University(清华大学生物医学工程学院);DAMO Academy, Alibaba Group(阿里集团达摩院);Hupan Lab(汇看实验室);Department of Radiology, Shengjing Hospital of China Medical University(中国医科大学附属盛京医院放射科);Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital of Zhejiang University(浙江大学医学院附属第一医院肝胆外科)
University of California, Los Angeles(加州大学洛杉矶分校);Cedars-Sinai Medical Center(西达赛奈医疗中心);Capital Medical University(首都医科大学);Fujian Medical University Union Hospital(福建医科大学附属协和医院);University of Southern California(南加州大学)
Segmentation of multiple organs-at-risk (OARs) is essential for radiation therapy treatment planning and other clinical applications. We developed an Automated deep Learning-based Abdominal Multi-Organ segmentation (ALAMO) framework based on 2D U-net and a densely connected network structure with tailored design in data augmentation and training procedures such as deep connection, auxiliary supervision, and multi-view. The model takes in multi-slice MR images and generates the output of segmentation results. Three-Tesla T1 VIBE (Volumetric Interpolated Breath-hold Examination) images of 102 su…
Dokuz Eylul University(多库兹·埃吕尔大学);Ca’ Foscari University of Venice(威尼斯大学);Ege University(爱琴海大学);IMT Atlantique(大西洋国立高等工业技术学院);Median Technologies(Median科技公司);University of Duisburg-Essen(杜伊斯堡-埃森大学);Otto von Guericke University(奥托·冯·格里克大学);Middle East Technical University(中东技术大学);Johns Hopkins University(约翰斯·霍普金斯大学)
Segmentation of abdominal organs has been a comprehensive, yet unresolved, research field for many years. In the last decade, intensive developments in deep learning (DL) have introduced new state-of-the-art segmentation systems. In order to expand the knowledge on these topics, the CHAOS - Combined (CT-MR) Healthy Abdominal Organ Segmentation challenge has been organized in conjunction with IEEE International Symposium on Biomedical Imaging (ISBI), 2019, in Venice, Italy. CHAOS provides both abdominal CT and MR data from healthy subjects for single and multiple abdominal organ segmentation. F…
Accurate segmentation of the liver is a prerequisite for the diagnosis of disease. Automated segmentation is an important application of computer-aided detection and diagnosis of liver disease. In recent years, automated processing of medical images has gained breakthroughs. However, the low contrast of abdominal scan CT images and the complexity of liver morphology make accurate automatic segmentation challenging. In this paper, we propose RA V-Net, which is an improved medical image automatic segmentation model based on U-Net. It has the following three main innovations. CofRes Module (Compo…
Scale-specific auxiliary multi-task contrastive learning for deep liver vessel segmentation
LaTIM UMR 1101(拉蒂姆UMR 1101机构);Inserm(法国国家健康与医学研究院);University of Western Brittany(西布列塔尼大学);University Hospital of Brest(布雷斯特大学医院);University Hospital of Poitiers(普瓦捷大学医院);ICube UMR 7357(ICube UMR 7357机构);CNRS(法国国家科学研究中心);IMT Atlantique(大西洋电信学院)
Robustly Optimized Deep Feature Decoupling Network for Fatty Liver Diseases Detection
School of Computing and Artificial Intelligence, Southwest Jiaotong University(西南交通大学计算机与人工智能学院);Department of Computer and Information Technology, Purdue University(普渡大学计算机与信息技术系);School of Computer Science, Chengdu University of Information Technology(成都信息工程大学计算机学院);University at Albany, State University of New York(纽约州立大学奥尔巴尼分校)
National Institutes of Health Clinical Center(美国国立卫生研究院临床中心)
Automatic organ segmentation is an important yet challenging problem for medical image analysis. The pancreas is an abdominal organ with very high anatomical variability. This inhibits previous segmentation methods from achieving high accuracies, especially compared to other organs such as the liver, heart or kidneys. In this paper, we present a probabilistic bottom-up approach for pancreas segmentation in abdominal computed tomography (CT) scans, using multi-level deep convolutional networks (ConvNets). We propose and evaluate several variations of deep ConvNets in the context of hierarchical…
Kyoto University(京都大学);Kyoto University Hospital(京都大学医院)
Respiratory motion and the associated deformations of abdominal organs and tumors are essential information in clinical applications. However, inter- and intra-patient multi-organ deformations are complex and have not been statistically formulated, whereas single organ deformations have been widely studied. In this paper, we introduce a multi-organ deformation library and its application to deformation reconstruction based on the shape features of multiple abdominal organs. Statistical multi-organ motion/deformation models of the stomach, liver, left and right kidneys, and duodenum were genera…
Accurate automatic organ segmentation is an important yet challenging problem for medical image analysis. The pancreas is an abdominal organ with very high anatomical variability. This inhibits traditional segmentation methods from achieving high accuracies, especially compared to other organs such as the liver, heart or kidneys. In this paper, we present a holistic learning approach that integrates semantic mid-level cues of deeply-learned organ interior and boundary maps via robust spatial aggregation using random forest. Our method generates boundary preserving pixel-wise class labels for p…
HANS-Net: Hyperbolic Convolution and Adaptive Temporal Attention for Accurate and Generalizable Liver and Tumor Segmentation in CT Imaging
Department of Computer Science and Engineering, United International University(计算机科学与工程系,国际大学);Faculty of Science and Technology, Charles Darwin University(科学与技术学院,查尔斯达尔文大学);Faculty of Science and Information Technology, Charles Darwin University(科学与信息技术学院,查尔斯达尔文大学)
Nagoya University(名古屋大学);Aichi Cancer Center(爱知癌症中心)
Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of full volumetric images. In this work, we show that a multi-class 3D FCN trained on manually labeled CT scans of seven abdominal structures (artery, vein, liver, spleen, stomach, gallbladder, and pancreas) can achieve competitive segmentation results, while avoiding the need for handcrafting features or training organ-specific models. To this end, we propose a two-stage, coarse-to-fine approach that trains an FCN model to roughly delineate the organs of interest in the first…
Shape reconstruction of deformable organs from two-dimensional X-ray images is a key technology for image-guided intervention. In this paper, we propose an image-to-graph convolutional network (IGCN) for deformable shape reconstruction from a single-viewpoint projection image. The IGCN learns relationship between shape/deformation variability and the deep image features based on a deformation mapping scheme. In experiments targeted to the respiratory motion of abdominal organs, we confirmed the proposed framework with a regularized loss function can reconstruct liver shapes from a single digit…
Vanderbilt University(范德堡大学);Sigma Technologies(12西格玛科技公司);Vanderbilt University Medical Center(范德堡大学医学中心)
Segmentation of abdominal computed tomography(CT) provides spatial context, morphological properties, and a framework for tissue-specific radiomics to guide quantitative Radiological assessment. A 2015 MICCAI challenge spurred substantial innovation in multi-organ abdominal CT segmentation with both traditional and deep learning methods. Recent innovations in deep methods have driven performance toward levels for which clinical translation is appealing. However, continued cross-validation on open datasets presents the risk of indirect knowledge contamination and could result in circular reason…
Imperial College London(伦敦帝国学院);Aichi Cancer Center(爱知县癌症中心);Nagoya University(名古屋大学)
To efficiently establish training databases for machine learning methods, collaborative and crowdsourcing platforms have been investigated to collectively tackle the annotation effort. However, when this concept is ported to the medical imaging domain, reading expertise will have a direct impact on the annotation accuracy. In this study, we examine the impact of expertise and the amount of available annotations on the accuracy outcome of a liver segmentation problem in an abdominal computed tomography (CT) image database. In controlled experiments, we study this impact for different types of w…