Risk stratification (characterization) of tumors from radiology images can be more accurate and faster with computer-aided diagnosis (CAD) tools. Tumor characterization through such tools can also enable non-invasive cancer staging, prognosis, and foster personalized treatment planning as a part of precision medicine. In this study, we propose both supervised and unsupervised machine learning strategies to improve tumor characterization. Our first approach is based on supervised learning for which we demonstrate significant gains with deep learning algorithms, particularly by utilizing a 3D Convolutional Neural Network and Transfer Learning. Motivated by the radiologists' interpretations of the scans, we then show how to incorporate task dependent feature representations into a CAD system via a graph-regularized sparse Multi-Task Learning (MTL) framework. In the second approach, we explore an unsupervised learning algorithm to address the limited availability of labeled training data, a common problem in medical imaging applications. Inspired by learning from label proportion (LLP) approaches in computer vision, we propose to use proportion-SVM for characterizing tumors. We also seek the answer to the fundamental question about the goodness of "deep features" for unsupervised tumor classification. We evaluate our proposed supervised and unsupervised learning algorithms on two different tumor diagnosis challenges: lung and pancreas with 1018 CT and 171 MRI scans, respectively, and obtain the state-of-the-art sensitivity and specificity results in both problems.
Beihang University(北京航空航天大学);University of Oxford(牛津大学);The Affiliated Hospital of Qingdao University(青岛大学附属医院)
As Deep Convolutional Neural Networks (DCNNs) have shown robust performance and results in medical image analysis, a number of deep-learning-based tumor detection methods were developed in recent years. Nowadays, the automatic detection of pancreatic tumors using contrast-enhanced Computed Tomography (CT) is widely applied for the diagnosis and staging of pancreatic cancer. Traditional hand-crafted methods only extract low-level features. Normal convolutional neural networks, however, fail to make full use of effective context information, which causes inferior detection results. In this paper…
School of Computer Science and Engineering, Southeast University(东南大学计算机科学与工程学院);Pancreas Centre, First Affiliated Hospital, Nanjing Medical University(南京医科大学第一附属医院胰腺中心);Department of General Surgery, First Affiliated Hospital, Nanjing Medical University(南京医科大学第一附属医院普外科);Big Data Computing Center of Southeast University(东南大学大数据计算中心)
A Weakly Supervised Segmentation Network Embedding Cross-scale Attention Guidance and Noise-sensitive Constraint for Detecting Tertiary Lymphoid Structures of Pancreatic Tumors
Nanjing University of Science and Technology(南京理工大学);Nanjing University(南京大学);Nanjing Drum Tower Hospital(南京鼓楼医院);Affiliated Hospital of Nanjing University of Chinese Medicine(南京中医药大学附属医院)
A Multi-Stage Fine-Tuning and Ensembling Strategy for Pancreatic Tumor Segmentation in Diagnostic and Therapeutic MRI
German Cancer Research Center (DKFZ) Heidelberg(德国癌症研究中心(DKFZ)海德堡);Faculty of Mathematics and Computer Science(数学与计算机科学学院);Heidelberg University(海德堡大学);Helmholtz Imaging, DKFZ(海德堡影像中心,DKFZ);Pattern Analysis and Learning Group(模式分析与学习小组);Department of Radiation Oncology(放射肿瘤科);Heidelberg University Hospital(海德堡大学医院);International School of Medicine(国际医学院);Istanbul Medipol University(伊斯坦布尔梅迪波尔大学)
PAII Inc.(PAII公司);Shengjing Hospital of China Medical University(中国医科大学附属盛京医院);Changhai Hospital(长海医院);Ping An Technology Co., Ltd.(平安科技(深圳)有限公司)
Accurate and automated tumor segmentation is highly desired since it has the great potential to increase the efficiency and reproducibility of computing more complete tumor measurements and imaging biomarkers, comparing to (often partial) human measurements. This is probably the only viable means to enable the large-scale clinical oncology patient studies that utilize medical imaging. Deep learning approaches have shown robust segmentation performances for certain types of tumors, e.g., brain tumors in MRI imaging, when a training dataset with plenty of pixel-level fully-annotated tumor images…
Radboud University Medical Center(拉德堡德大学医学中心);Radboud Institute for Health Sciences(拉德堡德健康科学研究所)
Early detection improves prognosis in pancreatic ductal adenocarcinoma (PDAC) but is challenging as lesions are often small and poorly defined on contrast-enhanced computed tomography scans (CE-CT). Deep learning can facilitate PDAC diagnosis, however current models still fail to identify small (<2cm) lesions. In this study, state-of-the-art deep learning models were used to develop an automatic framework for PDAC detection, focusing on small lesions. Additionally, the impact of integrating surrounding anatomy was investigated. CE-CT scans from a cohort of 119 pathology-proven PDAC patients an…
University of Oxford(牛津大学);Eindhoven University of Technology(埃因霍温理工大学);Utrecht Medical Center(乌得勒支医学中心)
Early detection of lung cancer has been proven to decrease mortality significantly. A recent development in computed tomography (CT), spectral CT, can potentially improve diagnostic accuracy, as it yields more information per scan than regular CT. However, the shear workload involved with analyzing a large number of scans drives the need for automated diagnosis methods. Therefore, we propose a detection and classification system for lung nodules in CT scans. Furthermore, we want to observe whether spectral images can increase classifier performance. For the detection of nodules we trained a VG…
Harvard University(哈佛大学);University of Central Florida(中佛罗里达大学)
Lung cancer is the leading cause of cancer related mortality by a significant margin. While new technologies, such as image segmentation, have been paramount to improved detection and earlier diagnoses, there are still significant challenges in treating the disease. In particular, despite an increased number of curative resections, many postoperative patients still develop recurrent lesions. Consequently, there is a significant need for prognostic tools that can more accurately predict a patient's risk for recurrence. In this paper, we explore the use of convolutional neural networks (CNNs) fo…
Indian Institute of Technology, Bombay(印度理工学院孟买分校);Tata Memorial Centre-ACTREC, HBNI(霍米·巴巴国立研究所塔塔纪念中心-先进治疗研究与教育中心);Tata Memorial Centre-TMH, HBNI(霍米·巴巴国立研究所塔塔纪念中心-塔塔纪念医院)
The standard diagnostic procedures for targeted therapies in lung cancer treatment involve histological subtyping and subsequent detection of key driver mutations, such as EGFR. Even though molecular profiling can uncover the driver mutation, the process is often expensive and time-consuming. Deep learning-oriented image analysis offers a more economical alternative for discovering driver mutations directly from whole slide images (WSIs). In this work, we used customized deep learning pipelines with weak supervision to identify the morphological correlates of EGFR mutation from hematoxylin and…
Southern Methodist University(南卫理公会大学);University of Texas at Dallas(德克萨斯大学达拉斯分校);University of Texas Southwestern Medical Center(德克萨斯大学西南医学中心)
Tumor shape is a key factor that affects tumor growth and metastasis. This paper proposes a topological feature computed by persistent homology to characterize tumor progression from digital pathology and radiology images and examines its effect on the time-to-event data. The proposed topological features are invariant to scale-preserving transformation and can summarize various tumor shape patterns. The topological features are represented in functional space and used as functional predictors in a functional Cox proportional hazards model. The proposed model enables interpretable inference ab…
Magnetic resonance delta radiomics to track radiation response in lung tumors receiving stereotactic MRI-guided radiotherapy
Mass General Brigham(麻省总医院布里格姆医疗系统);Harvard Medical School(哈佛医学院);Dana-Farber Cancer Institute(丹娜-法伯癌症研究所);Harvard T.H. Chan School of Public Health(哈佛大学陈曾熙公共卫生学院);Maastricht University(马斯特里赫特大学)
Foundation Models vs. Radiomics for Lung Computed Tomography: A Benchmark of Feature Extractors, Classification Heads, and Segmentation Choices
Division AI4Health, Carl von Ossietzky Universität Oldenburg(奥尔登堡卡尔·冯·奥西茨基大学AI4Health部门);University Institute for Diagnostic and Interventional Radiology, Klinikum Oldenburg AöR(奥尔登堡医院大学诊断与介入放射学研究所)
Memorial Sloan-Kettering Cancer Center(纪念斯隆-凯特琳癌症中心)
Lack of large expert annotated MR datasets makes training deep learning models difficult. Therefore, a cross-modality (MR-CT) deep learning segmentation approach that augments training data using pseudo MR images produced by transforming expert-segmented CT images was developed. Eighty-One T2-weighted MRI scans from 28 patients with non-small cell lung cancers were analyzed. Cross-modality prior encoding the transformation of CT to pseudo MR images resembling T2w MRI was learned as a generative adversarial deep learning model. This model augmented training data arising from 6 expert-segmented …
Memorial Sloan Kettering Cancer Center(纪念斯隆·凯特琳癌症中心)
Lung tumors, especially those located close to or surrounded by soft tissues like the mediastinum, are difficult to segment due to the low soft tissue contrast on computed tomography images. Magnetic resonance images contain superior soft-tissue contrast information that can be leveraged if both modalities were available for training. Therefore, we developed a cross-modality educed learning approach where MR information that is educed from CT is used to hallucinate MRI and improve CT segmentation. Our approach, called cross-modality educed deep learning segmentation (CMEDL) combines CT and pse…
A CT Image Classification Network Framework for Lung Tumors Based on Pre-trained MobileNetV2 Model and Transfer learning, And Its Application and Market Analysis in the Medical field
Johns Hopkins University(约翰斯·霍普金斯大学);University Hospital Basel(巴塞尔大学医院);Stanford University(斯坦福大学);University of California, San Francisco(加利福尼亚大学旧金山分校);Italian Institute of Technology(意大利技术研究院);University of Bologna(博洛尼亚大学);École Polytechnique Fédérale de Lausanne(洛桑联邦理工学院);Johns Hopkins Medicine(约翰斯·霍普金斯医疗集团)
Eindhoven University of Technology(埃因霍温理工大学);Catharina Ziekenhuis(凯瑟琳娜医院);Philips Research(飞利浦研究院)
Pancreatic cancer is one of the global leading causes of cancer-related deaths. Despite the success of Deep Learning in computer-aided diagnosis and detection (CAD) methods, little attention has been paid to the detection of Pancreatic Cancer. We propose a method for detecting pancreatic tumor that utilizes clinically-relevant features in the surrounding anatomical structures, thereby better aiming to exploit the radiologist's knowledge compared to other, conventional deep learning approaches. To this end, we collect a new dataset consisting of 99 cases with pancreatic ductal adenocarcinoma (P…
University of Toronto(多伦多大学);Lunenfeld-Tanenbaum Research Institute, Sinai Health System(西奈卫生系统卢嫩菲尔德-塔南鲍姆研究所);McMaster University(麦克马斯特大学);Hamilton Health Sciences(汉密尔顿健康科学中心);Sunnybrook Health Sciences Centre(桑尼布鲁克健康科学中心);Sunnybrook Research Institute(桑尼布鲁克研究所)
As an analytic pipeline for quantitative imaging feature extraction and analysis, radiomics has grown rapidly in the past a few years. Recent studies in radiomics aim to investigate the relationship between tumors imaging features and clinical outcomes. Open source radiomics feature banks enable the extraction and analysis of thousands of predefined features. On the other hand, recent advances in deep learning have shown significant potential in the quantitative medical imaging field, raising the research question of whether predefined radiomics features have predictive information in addition…
A Dual-Task Synergy-Driven Generalization Framework for Pancreatic Cancer Segmentation in CT Scans
Southwest Jiaotong University(西南交通大学);Shanghai Jiao Tong University(上海交通大学);The Second Affiliated Hospital of Guangzhou Medical University(广州医科大学附属第二医院)
Pancreatic Tumor Segmentation as Anomaly Detection in CT Images Using Denoising Diffusion Models
School of Electrical and Computer Engineering, University of Oklahoma(俄克拉荷马大学电气与计算机工程学院);University of Oklahoma Health Sciences Center(俄克拉荷马大学健康科学中心);School of Computer Science, University of Oklahoma(俄克拉荷马大学计算机科学学院)
CECT-Mamba: a Hierarchical Contrast-enhanced-aware Model for Pancreatic Tumor Subtyping from Multi-phase CECT
Southeast University(东南大学);Medical School of Southeast University(东南大学医学院);Zhongda Hospital(中大医院);Zhejiang University(浙江大学);The Hong Kong University of Science and Technology (Guangzhou)(香港科技大学(广州))
Memorial Sloan Kettering Cancer Center(纪念斯隆·凯特琳癌症中心)
Accurate and robust segmentation of lung cancers from CT, even those located close to mediastinum, is needed to more accurately plan and deliver radiotherapy and to measure treatment response. Therefore, we developed a new cross-modality educed distillation (CMEDL) approach, using unpaired CT and MRI scans, whereby an informative teacher MRI network guides a student CT network to extract features that signal the difference between foreground and background. Our contribution eliminates two requirements of distillation methods: (i) paired image sets by using an image to image (I2I) translation a…
East China Normal University(华东师范大学);Johns Hopkins University(约翰斯·霍普金斯大学);Shanghai Jiao Tong University(上海交通大学);Johns Hopkins University School of Medicine(约翰斯·霍普金斯大学医学院)
Pancreatic ductal adenocarcinoma (PDAC) is the third most common cause of cancer death in the United States. Predicting tumors like PDACs (including both classification and segmentation) from medical images by deep learning is becoming a growing trend, but usually a large number of annotated data are required for training, which is very labor-intensive and time-consuming. In this paper, we consider a partially supervised setting, where cheap image-level annotations are provided for all the training data, and the costly per-voxel annotations are only available for a subset of them. We propose a…
An Exceptional Dataset For Rare Pancreatic Tumor Segmentation
School of Computer Science, Fudan University(复旦大学计算机科学技术学院);Shanghai Medical College, Fudan University Shanghai Cancer Center(复旦大学上海医学院附属肿瘤医院);School of Computer Science, University of Illinois(伊利诺伊大学计算机科学学院)
The Johns Hopkins University(约翰斯·霍普金斯大学);The Johns Hopkins University School of Medicine(约翰斯·霍普金斯大学医学院)
This work presents comprehensive results to detect in the early stage the pancreatic neuroendocrine tumors (PNETs), a group of endocrine tumors arising in the pancreas, which are the second common type of pancreatic cancer, by checking the abdominal CT scans. To the best of our knowledge, this task has not been studied before as a computational task. To provide radiologists with tumor locations, we adopt a segmentation framework to classify CT volumes by checking if at least a sufficient number of voxels is segmented as tumors. To quantitatively analyze our method, we collect and voxelwisely l…
Concordia Institute for Information Systems Engineering, Concordia University(康考迪亚大学信息系统工程研究所);Sunnybrook Health Sciences Centre, University of Toronto(多伦多大学桑尼布鲁克健康科学中心);McGill University Health Center- Research Institute(麦吉尔大学健康中心研究所);Babak Imaging Center(巴布克影像中心);Department of Electrical and Computer Engineering, University of Toronto(多伦多大学电气与计算机工程系)
Lung diseases including infections such as Pneumonia, Tuberculosis, and novel Coronavirus (COVID-19), together with Lung Cancer are significantly widespread and are, typically, considered life threatening. In particular, lung cancer is among the most common and deadliest cancers with a low 5-year survival rate. Timely diagnosis of lung cancer is, therefore, of paramount importance as it can save countless lives. In this regard, deep learning radiomics solutions have the promise of extracting the most useful features on their own in an end-to-end fashion without having access to the annotated b…
National Institutes of Health Clinical Center(美国国立卫生研究院临床中心);National Cancer Institute(美国国家癌症研究所);National Institutes of Health(美国国立卫生研究院)
Tumor growth prediction, a highly challenging task, has long been viewed as a mathematical modeling problem, where the tumor growth pattern is personalized based on imaging and clinical data of a target patient. Though mathematical models yield promising results, their prediction accuracy may be limited by the absence of population trend data and personalized clinical characteristics. In this paper, we propose a statistical group learning approach to predict the tumor growth pattern that incorporates both the population trend and personalized data, in order to discover high-level features from…
Birla Institute of Technology and Science, Pilani(博拉理工学院皮拉尼校区);Hiroshima University(广岛大学);Keimyung University Dongsan Medical Center(启明大学东山医疗中心)
Lung cancer is one of the most deadly diseases in the world. Detecting such tumors at an early stage can be a tedious task. Existing deep learning architecture for lung nodule identification used complex architecture with large number of parameters. This study developed a cascaded architecture which can accurately segment and classify the benign or malignant lung nodules on computed tomography (CT) images. The main contribution of this study is to introduce a segmentation network where the first stage trained on a public data set can help to recognize the images which included a nodule from an…
National Institutes of Health Clinical Center(美国国立卫生研究院临床中心)
This paper reports Deep LOGISMOS approach to 3D tumor segmentation by incorporating boundary information derived from deep contextual learning to LOGISMOS - layered optimal graph image segmentation of multiple objects and surfaces. Accurate and reliable tumor segmentation is essential to tumor growth analysis and treatment selection. A fully convolutional network (FCN), UNet, is first trained using three adjacent 2D patches centered at the tumor, providing contextual UNet segmentation and probability map for each 2D patch. The UNet segmentation is then refined by Gaussian Mixture Model (GMM) a…
UiT The Arctic University of Norway(挪威北极大学);University Hospital of North Norway(北挪威大学医院)
Increased levels of tumor infiltrating lymphocytes (TILs) in cancer tissue indicate favourable outcomes in many types of cancer. Manual quantification of immune cells is inaccurate and time consuming for pathologists. Our aim is to leverage a computational solution to automatically quantify TILs in whole slide images (WSIs) of standard diagnostic haematoxylin and eosin stained sections (H&E slides) from lung cancer patients. Our approach is to transfer an open source machine learning method for segmentation and classification of nuclei in H&E slides trained on public data to TIL quantification…
Henry Ford Health System(亨利福特医疗系统);Wayne State University(韦恩州立大学)
Deep learning models have had a great success in disease classifications using large data pools of skin cancer images or lung X-rays. However, data scarcity has been the roadblock of applying deep learning models directly on prostate multiparametric MRI (mpMRI). Although model interpretation has been heavily studied for natural images for the past few years, there has been a lack of interpretation of deep learning models trained on medical images. This work designs a customized workflow for the small and imbalanced data set of prostate mpMRI where features were extracted from a deep learning m…
TextSAM-EUS: Text Prompt Learning for SAM to Accurately Segment Pancreatic Tumor in Endoscopic Ultrasound
Concordia University(康科迪亚大学);Jewish General Hospital(犹太总医院);McGill University Faculty of Medicine(麦吉尔大学医学院);Lady Davis Institute for Medical Research(拉德克利夫医学研究 institute)
Johns Hopkins University(约翰霍普金斯大学);University of Bologna(博洛尼亚大学);Italian Institute of Technology(意大利理工学院);University of California, San Francisco(加州大学旧金山分校);Istanbul Medipol University(伊斯坦布尔Medipol大学);University of Zurich(苏黎世大学);ETH AI Center(ETH人工智能中心);University of Illinois Urbana-Champaign(伊利诺伊大学厄巴纳-香槟分校);École Polytechnique Fédérale de Lausanne(洛桑联邦理工学院)
The Johns Hopkins University(约翰斯·霍普金斯大学);The Johns Hopkins University School of Medicine(约翰斯·霍普金斯大学医学院)
We propose an intuitive approach of detecting pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, by checking abdominal CT scans. Our idea is named multi-scale segmentation-for-classification, which classifies volumes by checking if at least a sufficient number of voxels is segmented as tumors, by which we can provide radiologists with tumor locations. In order to deal with tumors with different scales, we train and test our volumetric segmentation networks with multi-scale inputs in a coarse-to-fine flowchart. A post-processing module is used to filter out outl…
University of Sydney(悉尼大学);Royal Prince Alfred Hospital(阿尔弗雷德王子医院)
The analysis of multi-modality positron emission tomography and computed tomography (PET-CT) images for computer aided diagnosis applications requires combining the sensitivity of PET to detect abnormal regions with anatomical localization from CT. Current methods for PET-CT image analysis either process the modalities separately or fuse information from each modality based on knowledge about the image analysis task. These methods generally do not consider the spatially varying visual characteristics that encode different information across the different modalities, which have different priori…
Department of Computer Science, Johns Hopkins University(约翰霍普金斯大学计算机科学系);Department of Pharmacy and Biotechnology, University of Bologna(博洛尼亚大学药学与生物技术系);Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia(意大利技术研究院生物分子纳米技术中心);Faculty of Mathematics and Computer Science, Jagiellonian University(杰齐兰大学数学与计算机科学学院);Department of Cardiology and Internal Medicine, University of Warmia and Mazury(马尔堡大学心内科与内科系);Diagnostic and Treatment Center Gammed(Gammed诊断与治疗中心);Department of Bioengineering, University of Illinois Urbana-Champaign(伊利诺伊大学厄巴纳-香槟分校生物工程系);Department of General Surgery, Peking University Third Hospital(北京大学第三医院普外科);Department of Radiology & Biomedical Imaging, University of California, San Francisco(加州大学旧金山分校放射科与生物医学成像系);Department of Bioengineering, University of California, Berkeley(加州大学伯克利分校生物工程系);Department of Radiation Oncology, Johns Hopkins School of Medicine(约翰霍普金斯医学院放射肿瘤学系);NVIDIA Code, Models & Data(NVIDIA代码、模型与数据)
Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Korea(延世大学电气与计算机工程系);Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, Korea(延世大学医学院放射科与成像科学中心)
PAII Inc.(PAII 公司);Shengjing Hospital of China Medical University(中国医科大学附属盛京医院);Ping An Technology(平安科技)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and carries a dismal prognosis. Surgery remains the best chance of a potential cure for patients who are eligible for initial resection of PDAC. However, outcomes vary significantly even among the resected patients of the same stage and received similar treatments. Accurate preoperative prognosis of resectable PDACs for personalized treatment is thus highly desired. Nevertheless, there are no automated methods yet to fully exploit the contrast-enhanced computed tomography (CE-CT) imaging for PDAC. Tumor attenuation chang…
3DGAUnet: 3D generative adversarial networks with a 3D U-Net based generator to achieve the accurate and effective synthesis of clinical tumor image data for pancreatic cancer
University of Nebraska-Lincoln(内布拉斯加大学林肯分校);University of Nebraska Medical Center(内布拉斯加大学医学中心);University of Rochester Medical Center(罗切斯特大学医学中心)
Improved Prognostic Prediction of Pancreatic Cancer Using Multi-Phase CT by Integrating Neural Distance and Texture-Aware Transformer
DAMO Academy, Alibaba Group(阿里巴巴集团达摩院);Peking University(北京大学);Hupan Lab(湖畔实验室);Sun Yat-sen University Cancer Center(中山大学肿瘤防治中心);South China Hospital, Shenzhen University(深圳大学华南医院);Tianjin Medical University Cancer Institute and Hospital(天津医科大学肿瘤医院);Changsha Institute for Computing and Digital Economy(长沙计算与数字经济研究院);Guangdong Provincial People’s Hospital(广东省人民医院);Shengjing Hospital(盛京医院)
School of Information Technology(信息技术学院);University of Cincinnati(辛辛那提大学)
Lung cancer is the leading cause of death among different types of cancers. Every year, the lives lost due to lung cancer exceed those lost to pancreatic, breast, and prostate cancer combined. The survival rate for lung cancer patients is very low compared to other cancer patients due to late diagnostics. Thus, early lung cancer diagnostics is crucial for patients to receive early treatments, increasing the survival rate or even becoming cancer-free. This paper proposed a deep-learning model for early lung cancer prediction and diagnosis from Computed Tomography (CT) scans. The proposed mode a…
University of Jordan(约旦大学);University of Sussex(萨塞克斯大学)
Five different texture methods are used to investigate their susceptibility to subtle noise occurring in lung tumor Computed Tomography (CT) images caused by acquisition and reconstruction deficiencies. Noise of Gaussian and Rayleigh distributions with varying mean and variance was encountered in the analyzed CT images. Fisher and Bhattacharyya distance measures were used to differentiate between an original extracted lung tumor region of interest (ROI) with a filtered and noisy reconstructed versions. Through examining the texture characteristics of the lung tumor areas by five different text…
Can Foundation Models Really Segment Tumors? A Benchmarking Odyssey in Lung CT Imaging
College of Computer Science and Software Engineering, Shenzhen University(计算机科学与软件工程学院,深圳大学);Department of Naval, Electrical, Electronics and Telecommunications Engineering, University of Genoa(海军、电气、电子与电信工程部门,热那亚大学)