Tumor shape is a key factor that affects tumor growth and metastasis. This paper proposes a topological feature computed by persistent homology to characterize tumor progression from digital pathology and radiology images and examines its effect on the time-to-event data. The proposed topological features are invariant to scale-preserving transformation and can summarize various tumor shape patterns. The topological features are represented in functional space and used as functional predictors in a functional Cox proportional hazards model. The proposed model enables interpretable inference about the association between topological shape features and survival risks. Two case studies are conducted using consecutive 133 lung cancer and 77 brain tumor patients. The results of both studies show that the topological features predict survival prognosis after adjusting clinical variables, and the predicted high-risk groups have worse survival outcomes than the low-risk groups. Also, the topological shape features found to be positively associated with survival hazards are irregular and heterogeneous shape patterns, which are known to be related to tumor progression.
Cancer is the uncontrollable cell division of abnormal cells inside the human body, which can spread to other body organs. It is one of the non-communicable diseases (NCDs) and NCDs accounts for 71% of total deaths worldwide whereas lung cancer is the second most diagnosed cancer after female breast cancer. Cancer survival rate of lung cancer is only 19%. There are various methods for the diagnosis of lung cancer, such as X-ray, CT scan, PET-CT scan, bronchoscopy and biopsy. However, to know the subtype of lung cancer based on the tissue type H and E staining is widely used, where the staining…
Lung and Colon cancer are one of the leading causes of mortality and morbidity in adults. Histopathological diagnosis is one of the key components to discern cancer type. The aim of the present research is to propose a computer aided diagnosis system for diagnosing squamous cell carcinomas and adenocarcinomas of lung as well as adenocarcinomas of colon using convolutional neural networks by evaluating the digital pathology images for these cancers. Hereby, rendering artificial intelligence as useful technology in the near future. A total of 2500 digital images were acquired from LC25000 datase…
Kamnoetvidya Science Academy（甘烹碧科学学院）；National Electronics and Computer Technology Center（泰国国家电子和计算机技术中心）；Vidyasirimedhi Institute of Science and Technology（瓦莱拉克科学技术研究院）
Since, cancer is curable when diagnosed at an early stage, lung cancer screening plays an important role in preventive care. Although both low dose computed tomography (LDCT) and computed tomography (CT) scans provide more medical information than normal chest x-rays, there is very limited access to these technologies in rural areas. Recently, there is a trend in using computer-aided diagnosis (CADx) to assist in screening and diagnosing of cancer from biomedical images. In this study, the 121-layer convolutional neural network also known as DenseNet-121 by G. Huang et. al., along with the tra…
College of Aerospace Science and Engineering, National University of Defense Technology（国防科技大学航空航天科学与工程学院）；Eindhoven University of Technology（埃因霍温理工大学）；ScreenPoint Medical（ScreenPoint Medical 公司）；Pingan Technology（平安科技）；Lunit Inc.（Lunit 公司）；Queen Mary University of London（伦敦玛丽女王大学）；Beihang University（北京航空航天大学）；Beijing Advanced Innovation Center for Biomedical Engineering（北京生物医学工程高精尖创新中心）
Accurate segmentation of lung cancer in pathology slides is a critical step in improving patient care. We proposed the ACDC@LungHP (Automatic Cancer Detection and Classification in Whole-slide Lung Histopathology) challenge for evaluating different computer-aided diagnosis (CADs) methods on the automatic diagnosis of lung cancer. The ACDC@LungHP 2019 focused on segmentation (pixel-wise detection) of cancer tissue in whole slide imaging (WSI), using an annotated dataset of 150 training images and 50 test images from 200 patients. This paper reviews this challenge and summarizes the top 10 submi…
University of Technology Sydney（悉尼科技大学）；IBM Australia Limited（IBM澳大利亚有限公司）；Sejong University（世宗大学）；Universiti Kebangsaan Malaysia（马来西亚国民大学）；Charles Sturt University（查尔斯特大学）
Lung cancer is the leading cause of cancer death and morbidity worldwide. Many studies have shown machine learning models to be effective at detecting lung nodules from chest X-ray images. However, these techniques have yet to be embraced by the medical community due to several practical, ethical, and regulatory constraints stemming from the black-box nature of deep learning models. Additionally, most lung nodules visible on chest X-ray are benign; therefore, the narrow task of computer vision-based lung nodule detection cannot be equated to automated lung cancer detection. Addressing both con…
Rensselaer Polytechnic Institute（伦斯勒理工学院）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Niskayuna High School（尼斯卡尤纳高中）
Cancer patients have a higher risk of cardiovascular disease (CVD) mortality than the general population. Low dose computed tomography (LDCT) for lung cancer screening offers an opportunity for simultaneous CVD risk estimation in at-risk patients. Our deep learning CVD risk prediction model, trained with 30,286 LDCTs from the National Lung Cancer Screening Trial, achieved an area under the curve (AUC) of 0.871 on a separate test set of 2,085 subjects and identified patients with high CVD mortality risks (AUC of 0.768). We validated our model against ECG-gated cardiac CT based markers, includin…
Sunnybrook Health Sciences Centre（森尼布鲁克健康科学中心）；University of Waterloo（滑铁卢大学）；University of Toronto（多伦多大学）
Lung cancer is the leading cause for cancer related deaths. As such, there is an urgent need for a streamlined process that can allow radiologists to provide diagnosis with greater efficiency and accuracy. A powerful tool to do this is radiomics: a high-dimension imaging feature set. In this study, we take the idea of radiomics one step further by introducing the concept of discovery radiomics for lung cancer prediction using CT imaging data. In this study, we realize these custom radiomic sequencers as deep convolutional sequencers using a deep convolutional neural network learning architectu…
Arkansas State University（阿肯色州立大学）；University of Michigan（密歇根大学）；Ann Arbor Algorithm（安阿伯算法公司）；University of Arkansas at Pine Bluff（阿肯色大学松崖分校）；University of Arkansas for Medical Sciences（阿肯色大学医学院）
Lung cancer is the leading cause of cancer deaths. Early detection through low-dose computed tomography (CT) screening has been shown to significantly reduce mortality but suffers from a high false positive rate that leads to unnecessary diagnostic procedures. Quantitative image analysis coupled to deep learning techniques has the potential to reduce this false positive rate. We conducted a computational analysis of 1449 low-dose CT studies drawn from the National Lung Screening Trial (NLST) cohort. We applied to this cohort our newly developed algorithm, DeepScreener, which is based on a nove…
University of Technology Sydney（悉尼科技大学）；University of Sydney（悉尼大学）；Australian Artificial Intelligence Institute（澳大利亚人工智能研究所）
Lung cancer is the leading cause of cancer death worldwide. The critical reason for the deaths is delayed diagnosis and poor prognosis. With the accelerated development of deep learning techniques, it has been successfully applied extensively in many real-world applications, including health sectors such as medical image interpretation and disease diagnosis. By combining more modalities that being engaged in the processing of information, multimodal learning can extract better features and improve predictive ability. The conventional methods for lung cancer survival analysis normally utilize c…
Universitat Rovira i Virgili（罗维拉-威尔吉利大学）；University of Cagliari（卡利亚里大学）
In this paper, we examine the strength of deep learning technique for diagnosing lung cancer on medical image analysis problem. Convolutional neural networks (CNNs) models become popular among the pattern recognition and computer vision research area because of their promising outcome on generating high-level image representations. We propose a new deep learning architecture for learning high-level image representation to achieve high classification accuracy with low variance in medical image binary classification tasks. We aim to learn discriminant compact features at beginning of our deep co…
James A. Haley Veterans’ Hospital（詹姆斯·A·黑利退伍军人医院）；University of South Florida（南佛罗里达大学）；Moffitt Cancer Center（莫菲特癌症中心）
The field of Machine Learning, a subset of Artificial Intelligence, has led to remarkable advancements in many areas, including medicine. Machine Learning algorithms require large datasets to train computer models successfully. Although there are medical image datasets available, more image datasets are needed from a variety of medical entities, especially cancer pathology. Even more scarce are ML-ready image datasets. To address this need, we created an image dataset (LC25000) with 25,000 color images in 5 classes. Each class contains 5,000 images of the following histologic entities: colon a…
Medical Artificial Intelligence for Early Detection of Lung Cancer: A Survey
College of Computer Science and Artificial Intelligence, Southwest Minzu University, Chengdu, 610225, China（计算机科学与人工智能学院，西南民族大学）；The Australian National University, Canberra ACT 2601, Australia（澳大利亚国立大学）；School of Computer Science and Technology, Beijing Jiaotong University, Beijing, China（计算机科学与技术学校，北京交通大学）；Hunan university of technology, Zhuzhou, 410072, China（湖南理工大学）；University of Adelaide, Adelaide, South Australia 5005, Australia（阿德莱德大学）；La Trobe University, Melbourne, Victoria 3086, Australia（拉筹伯大学）
Lung cancer is among the most common cancers in the United States, in terms of incidence and mortality. In 2009, it is estimated that more than 150,000 deaths will result from lung cancer alone. Genetic information is an extremely valuable data source in characterizing the personal nature of cancer. Over the past several years, investigators have conducted numerous association studies where intensive genetic data is collected on relatively few patients compared to the numbers of gene predictors, with one scientific goal being to identify genetic features associated with cancer recurrence or su…
Comparative Analysis of Machine Learning Models for Lung Cancer Mutation Detection and Staging Using 3D CT Scans
Stanford Center for Biomedical Informatics Research (BMIR), Department of Medicine, Stanford University（斯坦福大学生物医学信息学研究中心（BMIR），医学系）；National Center for AI (NCAI), Saudi Data and AI Authority (SDAIA)（沙特数据与人工智能管理局国家人工智能中心（NCAI））；Department of Biomedical Data Science, Stanford University（斯坦福大学生物医学数据科学系）
National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute"（乌克兰国立技术大学“伊戈尔·西科斯基基辅理工学院”）；Huizhou University（惠州学院）
The recent progress of computing, machine learning, and especially deep learning, for image recognition brings a meaningful effect for automatic detection of various diseases from chest X-ray images (CXRs). Here efficiency of lung segmentation and bone shadow exclusion techniques is demonstrated for analysis of 2D CXRs by deep learning approach to help radiologists identify suspicious lesions and nodules in lung cancer patients. Training and validation was performed on the original JSRT dataset (dataset #01), BSE-JSRT dataset, i.e. the same JSRT dataset, but without clavicle and rib shadows (d…
MSAD-Net: Multiscale and Spatial Attention-based Dense Network for Lung Cancer Classification
Computer Science and Engineering Department, NIIT University, Jaipur, India（尼特大学计算机科学与工程系，印度斋普尔）；CSE department, Christ (Deemed to be University), Bangalore, India（基督大学（认定为大学）计算机科学与工程系，印度班加罗尔）；Faculty of Computing, Engineering and the Built Environment, Birmingham City University, UK（伯明翰城市大学计算、工程与建筑环境学院，英国）
We introduce a new computer aided detection and diagnosis system for lung cancer screening with low-dose CT scans that produces meaningful probability assessments. Our system is based entirely on 3D convolutional neural networks and achieves state-of-the-art performance for both lung nodule detection and malignancy classification tasks on the publicly available LUNA16 and Kaggle Data Science Bowl challenges. While nodule detection systems are typically designed and optimized on their own, we find that it is important to consider the coupling between detection and diagnosis components. Exploiti…
In this paper, we investigate the effectiveness of deep learning techniques for lung nodule classification in computed tomography scans. Using less than 10,000 training examples, our deep networks perform two times better than a standard radiology software. Visualization of the networks' neurons reveals semantically meaningful features that are consistent with the clinical knowledge and radiologists' perception. Our paper also proposes a novel framework for rapidly adapting deep networks to the radiologists' feedback, or change in the data due to the shift in sensor's resolution or patient pop…
AI generated annotations for Breast, Brain, Liver, Lungs and Prostate cancer collections in National Cancer Institute Imaging Data Commons
BAMF Health（BAMF健康公司）；National Institute of Health（美国国立卫生研究院）；Frederick National Laboratory for Cancer Research（弗雷德里克国家癌症研究实验室）；Brigham and Women’s Hospital（布莱根妇女医院）；Harvard Medical School（哈佛医学院）
In public health, various data are rigorously collected and published with open access. These data reflect the environmental and non-environmental characteristics of heterogeneous neighborhoods in cities. In the present study, we aimed to study the relations between these data and disease risks in heterogeneous neighborhoods. A flexible framework was developed to determine the key factors correlated with diseases and find the most relevant combination of factors to explain observations of diseases through nonlinear analyses. Taking Lung Cancer Premature Mortality Rate (LCPMR) in Toronto as an …
Traditional survival models such as the Cox proportional hazards model are typically based on scalar or categorical clinical features. With the advent of increasingly large image datasets, it has become feasible to incorporate quantitative image features into survival prediction. So far, this kind of analysis is mostly based on radiomics features, i.e. a fixed set of features that is mathematically defined a priori. To capture highly abstract information, it is desirable to learn the feature extraction using convolutional neural networks. However, for tomographic medical images, model training…
A Lung Nodule Dataset with Histopathology-based Cancer Type Annotation
School of Computer Science and Technology, Shandong University of Finance and Economics（山东财经大学计算机科学与技术学院）；School of Information Science and Technology, Linyi University（临沂大学信息科学与技术学院）；Thoracic Surgery Department of Linyi Central Hospital（临沂市中心医院胸外科）；Personnel Department of Linyi Central Hospital（临沂市中心医院人事科）
Fairness Evaluation of Risk Estimation Models for Lung Cancer Screening
Diagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center（放射医学成像分析组，医学影像系，拉德堡德大学医学中心）；Department of Artificial Intelligence, Radboud University（人工智能系，拉德堡德大学）；Ethics of Healthcare Group, Department IQ Health, Radboud University Medical Center（医疗伦理组，IQ健康系，拉德堡德大学医学中心）
Feature-interactive Siamese graph encoder-based image analysis to predict STAS from histopathology images in lung cancer
Hunan University（湖南大学）；The Second Xiangya Hospital, Central South University（中南大学湘雅二医院）；Central South University（中南大学）；Hunan Clinical Medical Research Center for Cancer Pathogenic Genes Testing and Diagnosis（湖南省肿瘤致病基因检测与诊断临床医学研究中心）；Shanghai Cancer Institute（上海市肿瘤研究所）；Renji Hospital, School of Medicine, Shanghai Jiaotong University（上海交通大学医学院附属仁济医院）；Shanghai Jiaotong University（上海交通大学）
Dual-Modal Lung Cancer AI: Interpretable Radiology and Microscopy with Clinical Risk Integration
Hatyaiwittayalai School（哈雅维泰莱学校）；School of Information, Computer, and Communication Technology（信息、计算机与通信技术学院）；Sirindhorn International Institute of Technology（Sirindhorn国际技术学院）；Thammasat University（泰国朱拉大学）；Pathum Thani, Thailand（帕亨他尼，泰国）
Mohamed bin Zayed University of Artificial Intelligence（穆罕默德·本·扎耶德人工智能大学）
Lung cancer is a leading cause of death worldwide. Early-stage detection of lung cancer is essential for a more favorable prognosis. Radiogenomics is an emerging discipline that combines medical imaging and genomics features for modeling patient outcomes non-invasively. This study presents a radiogenomics pipeline that has: 1) a novel mixed architecture (RA-Seg) to segment lung cancer through attention and recurrent blocks; and 2) deep feature classifiers to distinguish Epidermal Growth Factor Receptor (EGFR) mutation status. We evaluate the proposed algorithm on multiple public datasets to as…
Harnessing Transformers: A Leap Forward in Lung Cancer Image Detection
Laboratoire LITAN École supérieure en Sciences et Technologies de l’Informatique et du Numérique（高等计算机与数字科学技术学院 LITAN 实验室）；College of Engineering and Information Technology, University of Dubai（迪拜大学工程与信息技术学院）；Department of Computer Science, University of Sharjah（沙迦大学计算机科学系）；Institute of Artificial Intelligence, De Montfort University（德蒙福特大学人工智能研究所）
University of Michigan（密歇根大学）；Imbio LLC（Imbio有限责任公司）
Early detection of lung cancer is critical for improvement of patient survival. To address the clinical need for efficacious treatments, genetically engineered mouse models (GEMM) have become integral in identifying and evaluating the molecular underpinnings of this complex disease that may be exploited as therapeutic targets. Assessment of GEMM tumor burden on histopathological sections performed by manual inspection is both time consuming and prone to subjective bias. Therefore, an interplay of needs and challenges exists for computer-aided diagnostic tools, for accurate and efficient analys…
Classification based deep learning models for lung cancer and disease using medical images
Laboratory for Artificial Intelligence of Personalized Medicine, School of Artificial Intelligence, Guilin University of Electronic Technology（人工智能个性化医学实验室，人工智能学院，桂林电子科技大学）；The Laboratory for Imagery, Vision and Artificial Intelligence, Ecole de Technologie Superieure（影像、视觉与人工智能实验室，蒙特利尔理工学院）
SMILE: a Scale-aware Multiple Instance Learning Method for Multicenter STAS Lung Cancer Histopathology Diagnosis
College of Computer Science and Electronic Engineering, Hunan University（湖南大学计算机与通信工程学院）；College of Information Science and Engineering, Hunan Normal University（湖南师范大学信息科学与工程学院）；The Second Xiangya Hospital, Central South University（中南大学湘雅二医院）
University of Waterloo（滑铁卢大学）；Vector Institute（向量研究所）
Representation learning for Whole Slide Images (WSIs) is pivotal in developing image-based systems to achieve higher precision in diagnostic pathology. We propose a two-stage framework for WSI representation learning. We sample relevant patches using a color-based method and use graph neural networks to learn relations among sampled patches to aggregate the image information into a single vector representation. We introduce attention via graph pooling to automatically infer patches with higher relevance. We demonstrate the performance of our approach for discriminating two sub-types of lung ca…
School of Information Technology（信息技术学院）；University of Cincinnati（辛辛那提大学）
Lung cancer is the leading cause of death among different types of cancers. Every year, the lives lost due to lung cancer exceed those lost to pancreatic, breast, and prostate cancer combined. The survival rate for lung cancer patients is very low compared to other cancer patients due to late diagnostics. Thus, early lung cancer diagnostics is crucial for patients to receive early treatments, increasing the survival rate or even becoming cancer-free. This paper proposed a deep-learning model for early lung cancer prediction and diagnosis from Computed Tomography (CT) scans. The proposed mode a…
NMAM Institute of Technology（NMAM理工学院）；Visvesvaraya Technological University（韦斯韦斯瓦拉亚理工大学）；Sahyadri College of Engineering and Management（萨亚德里工程与管理学院）；JSS Academy of Technical Education（JSS技术教育学院）
Lung cancer begins in the lungs and leading to the reason of cancer demise amid population in the creation. According to the American Cancer Society, which estimates about 27% of the deaths because of cancer. In the early phase of its evolution, lung cancer does not cause any symptoms usually. Many of the patients have been diagnosed in a developed phase where symptoms become more prominent, that results in poor curative treatment and high mortality rate. Computer Aided Detection systems are used to achieve greater accuracies for the lung cancer diagnosis. In this research exertion, we propose…
Lung cancer is the leading cause of cancer-related deaths in the past several years. A major challenge in lung cancer screening is the detection of lung nodules from computed tomography (CT) scans. State-of-the-art approaches in automated lung nodule classification use deep convolutional neural networks (CNNs). However, these networks require a large number of training samples to generalize well. This paper investigates the use of capsule networks (CapsNets) as an alternative to CNNs. We show that CapsNets significantly outperforms CNNs when the number of training samples is small. To increase…
With an estimated 160,000 deaths in 2018, lung cancer is the most common cause of cancer death in the United States. Lung cancer CT screening has been shown to reduce mortality by up to 40% and is now included in US screening guidelines. Reducing the high error rates in lung cancer screening is imperative because of the high clinical and financial costs caused by diagnosis mistakes. Despite the use of standards for radiological diagnosis, persistent inter-grader variability and incomplete characterization of comprehensive imaging findings remain as limitations of current methods. These limitat…
Institute for Infocomm Research（资讯通信研究院）；CentraleSupélec（巴黎中央理工-高等电力学院）；National Cancer Centre Singapore（新加坡国立癌症中心）；Hunan University（湖南大学）；Chesed Radiology（Chesed放射学）；Nanyang Technological University（南洋理工大学）
We present a deep learning framework for computer-aided lung cancer diagnosis. Our multi-stage framework detects nodules in 3D lung CAT scans, determines if each nodule is malignant, and finally assigns a cancer probability based on these results. We discuss the challenges and advantages of our framework. In the Kaggle Data Science Bowl 2017, our framework ranked 41st out of 1972 teams.
Lung cancer is the leading cause of cancer-related death worldwide. Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are the most common histologic subtypes of non-small-cell lung cancer (NSCLC). Histology is an essential tool for lung cancer diagnosis. Pathologists make classifications according to the dominant subtypes. Although morphology remains the standard for diagnosis, significant tool needs to be developed to elucidate the diagnosis. In our study, we utilize the pre-trained Vision Transformer (ViT) model to classify multiple label lung cancer on histologic slices (fr…
Northwestern University, Feinberg School of Medicine（西北大学范伯格医学院）；University of Illinois at Chicago（伊利诺伊大学芝加哥分校）；Mayo Clinic（妙佑医疗国际）
The recent development of imaging and sequencing technologies enables systematic advances in the clinical study of lung cancer. Meanwhile, the human mind is limited in effectively handling and fully utilizing the accumulation of such enormous amounts of data. Machine learning-based approaches play a critical role in integrating and analyzing these large and complex datasets, which have extensively characterized lung cancer through the use of different perspectives from these accrued data. In this article, we provide an overview of machine learning-based approaches that strengthen the varying a…
LungEvaty: A Scalable, Open-Source Transformer-based Deep Learning Model for Lung Cancer Risk Prediction in LDCT Screening
Technical University of Munich (TUM)（慕尼黑技术大学）；TUM University Hospital（慕尼黑技术大学医院）；Imperial College London（伦敦帝国学院）；Munich Center for Machine Learning (MCML)（慕尼黑机器学习中心）
University of Waterloo（滑铁卢大学）；University of Guelph（圭尔夫大学）；Vector Institute（向量研究所）
Objective: Lung cancer is the leading cause of cancer-related death worldwide. Computer-aided diagnosis (CAD) systems have shown significant promise in recent years for facilitating the effective detection and classification of abnormal lung nodules in computed tomography (CT) scans. While hand-engineered radiomic features have been traditionally used for lung cancer prediction, there have been significant recent successes achieving state-of-the-art results in the area of discovery radiomics. Here, radiomic sequencers comprising of highly discriminative radiomic features are discovered directl…
University of Applied Sciences - Wiener Neustadt（维也纳新城应用科学大学）；LAAS-CNRS（法国国家科学研究中心 LAAS 实验室）；Univ de Toulouse（图卢兹大学）
Lung cancer accounts for the highest number of cancer deaths globally. Early diagnosis of lung nodules is very important to reduce the mortality rate of patients by improving the diagnosis and treatment of lung cancer. This work proposes an automated system to classify lung nodules as malignant and benign in CT images. It presents extensive experimental results using a combination of geometric and histogram lung nodule image features and different linear and non-linear discriminant classifiers. The proposed approach is experimentally validated on the LIDC-IDRI public lung cancer screening thor…
