This paper introduces a statistical test inferring whether a variable allows separating two classes by means of a single critical value. Its test statistic is the prediction error of a nonparametric threshold classifier. While this approach is adequate for univariate classification tasks, it is especially advantageous for filter-type variable selection. It constitutes a robust and nonparametric method which may identify important otherwise neglected variables. It can incorporate the operating conditions of the classification task. Last but not least, the exact finite sample distribution of the test statistic under the null hypothesis can be calculated using a fast recursive algorithm.
We derive a new class of statistical tests for generalized linear models based on thresholding point estimators. These tests can be employed whether the model includes more parameters than observations or not. For linear models, our tests rely on pivotal statistics derived from model selection techniques. Affine lasso, a new extension of lasso, allows to unveil new tests and to develop in the same framework parametric and nonparametric tests. Our tests for generalized linear models are based on new asymptotically pivotal statistics. A composite thresholding test attempts to achieve uniformly m…
The assumption of separability of the covariance operator for a random image or hypersurface can be of substantial use in applications, especially in situations where the accurate estimation of the full covariance structure is unfeasible, either for computational reasons, or due to a small sample size. However, inferential tools to verify this assumption are somewhat lacking in high-dimensional or functional {data analysis} settings, where this assumption is most relevant. We propose here to test separability by focusing on $K$-dimensional projections of the difference between the covariance o…
The varying-coefficient model is an important nonparametric statistical model that allows us to examine how the effects of covariates vary with exposure variables. When the number of covariates is big, the issue of variable selection arrives. In this paper, we propose and investigate marginal nonparametric screening methods to screen variables in ultra-high dimensional sparse varying-coefficient models. The proposed nonparametric independence screening (NIS) selects variables by ranking a measure of the nonparametric marginal contributions of each covariate given the exposure variable. The sur…
We address the issue of variable selection in the regression model with very high ambient dimension, i.e., when the number of covariates is very large. The main focus is on the situation where the number of relevant covariates, called intrinsic dimension, is much smaller than the ambient dimension. Without assuming any parametric form of the underlying regression function, we get tight conditions making it possible to consistently estimate the set of relevant variables. These conditions relate the intrinsic dimension to the ambient dimension and to the sample size. The procedure that is provab…
Identifying a biomarker or treatment-dose threshold that marks a specified level of risk is an important problem, especially in clinical trials. This risk, viewed as a function of thresholds and possibly adjusted for covariates, we call the threshold-response function. Extending the work of Donovan, Hudgens and Gilbert (2019), we propose a nonparametric efficient estimator for the covariate-adjusted threshold-response function, which utilizes machine learning and Targeted Minimum-Loss Estimation (TMLE). We additionally propose a more general estimator, based on sequential regression, that also…
It is common to assume in empirical research that observables and unobservables are additively separable, especially, when the former are endogenous. This is done because it is widely recognized that identification and estimation challenges arise when interactions between the two are allowed for. Starting from a nonseparable IV model, where the instrumental variable is independent of unobservables, we develop a novel nonparametric test of separability of unobservables. The large-sample distribution of the test statistics is nonstandard and relies on a novel Donsker-type central limit theorem f…
One of the most popular methodologies for estimating the average treatment effect at the threshold in a regression discontinuity design is local linear regression (LLR), which places larger weight on units closer to the threshold. We propose a Gaussian process regression methodology that acts as a Bayesian analog to LLR for regression discontinuity designs. Our methodology provides a flexible fit for treatment and control responses by placing a general prior on the mean response functions. Furthermore, unlike LLR, our methodology can incorporate uncertainty in how units are weighted when estim…
This paper studies the validity of nonparametric tests used in the regression discontinuity design. The null hypothesis of interest is that the average treatment effect at the threshold in the so-called sharp design equals a pre-specified value. We first show that, under assumptions used in the majority of the literature, for \emph{any} test the power against any alternative is bounded above by its size. This result implies that, under these assumptions, any test with nontrivial power will exhibit size distortions. We next provide a sufficient strengthening of the standard assumptions under wh…
Regional frequency analysis is an important tool to properly estimate hydrological characteristics at ungauged or partially gauged sites in order to prevent hydrological disasters. The delineation of homogeneous groups of sites is an important first step in order to transfer information and obtain accurate quantile estimates at the target site. The Hosking-Wallis homogeneity test is usually used to test the homogeneity of the selected sites. Despite its usefulness and good power, it presents some drawbacks including the subjective choice of a parametric distribution for the data and a poorly j…
We introduce a new set of models and adaptive psychometric testing methods for multidimensional psychophysics. In contrast to traditional adaptive staircase methods like PEST and QUEST, the method is multi-dimensional and does not require a grid over contextual dimensions, retaining sub-exponential scaling in the number of stimulus dimensions. In contrast to more recent multi-dimensional adaptive methods, our underlying model does not require a parametric assumption about the interaction between intensity and the additional dimensions. In addition, we introduce a new active sampling policy tha…
Astrophysicists are interested in recovering the 3D gas emissivity of a galaxy cluster from a 2D image taken by a telescope. A blurring phenomenon and presence of point sources make this inverse problem even harder to solve. The current state-of-the-art technique is two step: first identify the location of potential point sources, then mask these locations and deproject the data. We instead model the data as a Poisson generalized linear model (involving blurring, Abel and wavelets operators) regularized by two lasso penalties to induce sparse wavelet representation and sparse point sources. Th…
This study investigates two-stage plans based on nonparametric procedures for estimating an inverse regression function at a given point. Specifically, isotonic regression is used at stage one to obtain an initial estimate followed by another round of isotonic regression in the vicinity of this estimate at stage two. It is shown that such two stage plans accelerate the convergence rate of one-stage procedures and are superior to existing two-stage procedures that use local parametric approximations at stage two when the available budget is moderate and/or the regression function is 'ill-behave…
A general class of models is proposed that is able to estimate the whole predictive distribution of a dependent variable $Y$ given a vector of explanatory variables $\xb$. The models exploit that the strength of explanatory variables to distinguish between low and high values of the dependent variable may vary across the thresholds that are used to define low and high. Simple linear versions of the models are generalizations of classical linear regression models but also of widely used ordinal regression models. They allow to visualize the effect of explanatory variables in the form of paramet…
The aim of online monitoring is to issue an alarm as soon as there is significant evidence in the collected observations to suggest that the underlying data generating mechanism has changed. This work is concerned with open-end, nonparametric procedures that can be interpreted as statistical tests. The proposed monitoring schemes consist of computing the so-called retrospective CUSUM statistic (or minor variations thereof) after the arrival of each new observation. After proposing suitable threshold functions for the chosen detectors, the asymptotic validity of the procedures is investigated i…
Given a sample of independent and identically distributed random variables, a novel nonparametric maximum entropy method is presented to estimate the underlying continuous univariate probability density function (pdf). Estimates are found by maximizing a log-likelihood function based on single order statistics after transforming through a sequence of trial cumulative distribution functions that iteratively improve using a Monte Carlo random search method. Improvement is quantified by assessing the random variables against the statistical properties of sampled uniform random data. Quality is de…
High-throughput scientific studies involving no clear a'priori hypothesis are common. For example, a large-scale genomic study of a disease may examine thousands of genes without hypothesizing that any specific gene is responsible for the disease. In these studies, the objective is to explore a large number of possible factors (e.g. genes) in order to identify a small number that will be considered in follow-up studies that tend to be more thorough and on smaller scales. For large-scale studies, we propose a nonparametric Bayesian approach based on random partition models. Our model thus divid…
