We introduce a new set of models and adaptive psychometric testing methods for multidimensional psychophysics. In contrast to traditional adaptive staircase methods like PEST and QUEST, the method is multi-dimensional and does not require a grid over contextual dimensions, retaining sub-exponential scaling in the number of stimulus dimensions. In contrast to more recent multi-dimensional adaptive methods, our underlying model does not require a parametric assumption about the interaction between intensity and the additional dimensions. In addition, we introduce a new active sampling policy that explicitly targets psychometric detection threshold estimation and does so substantially faster than policies that attempt to estimate the full psychometric function (though it still provides estimates of the function, albeit with lower accuracy). Finally, we introduce AEPsych, a user-friendly open-source package for nonparametric psychophysics that makes these technically-challenging methods accessible to the broader community.
A general framework for adaptive nonparametric dimensionality reduction
Seminar for Statistics, Department of Mathematics, ETH Zurich（苏黎世联邦理工学院统计研究所，数学系）；Faculty of Economics, Euler Institute, Università della Svizzera italiana（瑞士意大利大学经济学院，欧拉研究所）；Faculty of Informatics, Università della Svizzera italiana（瑞士意大利大学信息学院）；Department of Science and High Technology, University of Insubria（意大利因布里亚大学科学与高科技系）
While adaptive sensing has provided improved rates of convergence in sparse regression and classification, results in nonparametric regression have so far been restricted to quite specific classes of functions. In this paper, we describe an adaptive-sensing algorithm which is applicable to general nonparametric-regression problems. The algorithm is spatially adaptive, and achieves improved rates of convergence over spatially inhomogeneous functions. Over standard function classes, it likewise retains the spatial adaptivity properties of a uniform design.
Since Stein's 1956 seminal paper, shrinkage has played a fundamental role in both parametric and nonparametric inference. This article discusses minimaxity and adaptive minimaxity in nonparametric function estimation. Three interrelated problems, function estimation under global integrated squared error, estimation under pointwise squared error, and nonparametric confidence intervals, are considered. Shrinkage is pivotal in the development of both the minimax theory and the adaptation theory. While the three problems are closely connected and the minimax theories bear some similarities, the ad…
Nonparametric control charts that can detect arbitrary distributional changes are highly desirable due to their flexibility to adapt to different distributional assumptions and distributional changes. However, most of such control charts in the literature either involve some tuning parameter, which needs to be pre-specified, or involve intensive computation. In this paper, we propose a new nonparametric adaptive CUSUM chart for detecting arbitrary distributional changes. The proposed control chart does not depend on any tuning parameter and is efficient in computation. Its self-starting nature…
We introduce a hierarchical nonparametric model for probability measures based on a multi-resolution transformation of probability distributions. The model allows a varying amount of shrinkage to be applied to data features of different scales and/or at different locations in the sample space, and the varying shrinkage level is locally adaptive to the empirical behavior of the data. Moreover, the model's hierarchical design---through a latent Markov tree structure---allows borrowing of information across locations and scales in setting the adaptive shrinkage level. Inference under the model pr…
In this paper we propose a general class of covariate-adjusted response-adaptive (CARA) designs based on a new functional urn model. We prove strong consistency concerning the functional urn proportion and the proportion of subjects assigned to the treatment groups, in the whole study and for each covariate profile, allowing the distribution of the responses conditioned on covariates to be estimated nonparametrically. In addition, we establish joint central limit theorems for the above quantities and the sufficient statistics of features of interest, which allow to construct procedures to make…
We propose a nested Gaussian process (nGP) as a locally adaptive prior for Bayesian nonparametric regression. Specified through a set of stochastic differential equations (SDEs), the nGP imposes a Gaussian process prior for the function's $m$th-order derivative. The nesting comes in through including a local instantaneous mean function, which is drawn from another Gaussian process inducing adaptivity to locally-varying smoothness. We discuss the support of the nGP prior in terms of the closure of a reproducing kernel Hilbert space, and consider theoretical properties of the posterior. The post…
We investigate the nonparametric bivariate additive regression estimation in the random design and long-memory errors and construct adaptive thresholding estimators based on wavelet series. The proposed approach achieves asymptotically near-optimal convergence rates when the unknown function and its univariate additive components belong to Besov space. We consider the problem under two noise structures; (1) homoskedastic Gaussian long memory errors and (2) heteroskedastic Gaussian long memory errors. In the homoskedastic long-memory error case, the estimator is completely adaptive with respect…
Nonparametric efficient causal estimation of the intervention-specific expected number of recurrent events with continuous-time targeted maximum likelihood and highly adaptive lasso estimation
This paper considers adaptive, minimax estimation of a quadratic functional in a nonparametric instrumental variables (NPIV) model, which is an important problem in optimal estimation of a nonlinear functional of an ill-posed inverse regression with an unknown operator. We first show that a leave-one-out, sieve NPIV estimator of the quadratic functional can attain a convergence rate that coincides with the lower bound previously derived in Chen and Christensen [2018]. The minimax rate is achieved by the optimal choice of the sieve dimension (a key tuning parameter) that depends on the smoothne…
Cryo-electron microscopy (cryo-EM) is an emerging experimental method to characterize the structure of large biomolecular assemblies. Single particle cryo-EM records 2D images (so-called micrographs) of projections of the three-dimensional particle, which need to be processed to obtain the three-dimensional reconstruction. A crucial step in the reconstruction process is particle picking which involves detection of particles in noisy 2D micrographs with low signal-to-noise ratios of typically 1:10 or even lower. Typically, each picture contains a large number of particles, and particles have un…
Inverse probability weighted estimators are the oldest and potentially most commonly used class of procedures for the estimation of causal effects. By adjusting for selection biases via a weighting mechanism, these procedures estimate an effect of interest by constructing a pseudo-population in which selection biases are eliminated. Despite their ease of use, these estimators require the correct specification of a model for the weighting mechanism, are known to be inefficient, and suffer from the curse of dimensionality. We propose a class of nonparametric inverse probability weighted estimato…
We consider the problem of bandwidth selection by cross-validation from a sequential point of view in a nonparametric regression model. Having in mind that in applications one often aims at estimation, prediction and change detection simultaneously, we investigate that approach for sequential kernel smoothers in order to base these tasks on a single statistic. We provide uniform weak laws of large numbers and weak consistency results for the cross-validated bandwidth. Extensions to weakly dependent error terms are discussed as well. The errors may be α-mixing or L2-near epoch dependent, which …
The Highly-Adaptive-LASSO Targeted Minimum Loss Estimator (HAL-TMLE) is an efficient plug-in estimator of a pathwise differentiable parameter in a statistical model that at minimal (and possibly only) assumes that the sectional variation norm of the true nuisance functional parameters (i.e., the relevant part of data distribution) are finite. It relies on an initial estimator (HAL-MLE) of the nuisance functional parameters by minimizing the empirical risk over the parameter space under the constraint that the sectional variation norm of the candidate functions are bounded by a constant, where …
Human learners have the natural ability to use knowledge gained in one setting for learning in a different but related setting. This ability to transfer knowledge from one task to another is essential for effective learning. In this paper, we study transfer learning in the context of nonparametric classification based on observations from different distributions under the posterior drift model, which is a general framework and arises in many practical problems. We first establish the minimax rate of convergence and construct a rate-optimal two-sample weighted $K$-NN classifier. The results cha…
Cost-effectiveness analyses (CEAs) are at the center of health economic decision making. While these analyses help policy analysts and economists determine coverage, inform policy, and guide resource allocation, they are statistically challenging for several reasons. Cost and effectiveness are correlated and follow complex joint distributions which are difficult to capture parametrically. Effectiveness (often measured as increased survival time) and accumulated cost tends to be right-censored in many applications. Moreover, CEAs are often conducted using observational data with non-random trea…
We present a locally adaptive nonparametric curve fitting method that operates within a fully Bayesian framework. This method uses shrinkage priors to induce sparsity in order-k differences in the latent trend function, providing a combination of local adaptation and global control. Using a scale mixture of normals representation of shrinkage priors, we make explicit connections between our method and kth order Gaussian Markov random field smoothing. We call the resulting processes shrinkage prior Markov random fields (SPMRFs). We use Hamiltonian Monte Carlo to approximate the posterior distri…
We consider the problem of non-parametric regression with a potentially large number of covariates. We propose a convex, penalized estimation framework that is particularly well-suited for high-dimensional sparse additive models. The proposed approach combines appealing features of finite basis representation and smoothing penalties for non-parametric estimation. In particular, in the case of additive models, a finite basis representation provides a parsimonious representation for fitted functions but is not adaptive when component functions posses different levels of complexity. On the other …
Consider nonparametric function estimation under $L^p$-loss. The minimax rate for estimation of the regression function over a Hölder ball with smoothness index $β$ is $n^{-β/(2β+1)}$ if $1\leq p<\infty$ and $(n/\log n)^{-β/(2β+1)}$ if $p=\infty.$ There are many known procedures that either attain this rate for $p=\infty$ but are suboptimal by a $\log n$ factor in the case $p<\infty$ or the other way around. In this article, we construct an estimator that simultaneously achieves the optimal rates under $L^p$-risk for all $1\leq p\leq \infty$ without prior knowledge of $β.$ In contrast to class…
In this paper we propose a new adaptive wavelet denoising methodology using complex wavelets. The method is based on a fully Bayesian hierarchical model in the complex wavelet domain that uses a bivariate mixture prior on the wavelet coefficients. The heart of the procedure is computational, where the posterior mean is computed through Markov chain Monte Carlo (MCMC) simulations. We show that the method has good performance, as demonstrated by simulations on the well-known test functions and by comparison to a well-established complex wavelet-based denoising procedure. An application to real-l…
A dimension reduction-based adaptive-to-model test is proposed for significance of a subset of covariates in the context of a nonparametric regression model. Unlike existing local smoothing significance tests, the new test behaves like a local smoothing test as if the number of covariates were just that under the null hypothesis and it can detect local alternatives distinct from the null at the rate that is only related to the number of covariates under the null hypothesis. Thus, the curse of dimensionality is largely alleviated when nonparametric estimation is inevitably required. In the case…
This article introduces a nonparametric approach to multivariate time-varying power spectrum analysis. The procedure adaptively partitions a time series into an unknown number of approximately stationary segments, where some spectral components may remain unchanged across segments, allowing components to evolve differently over time. Local spectra within segments are fit through Whittle likelihood based penalized spline models of modified Cholesky components, which provide flexible nonparametric estimates that preserve positive definite structures of spectral matrices. The approach is formulat…
