Airway segmentation from 3D chest CT volumes based on volume of interest using gradient vector flow
Graduate School of Information Science, Nagoya University（名古屋大学信息科学研究科）；School of Information Science, Aichi Institute of Technology（爱知工业大学信息科学学院）；Graduate School of Health Sciences, Tokushima University（德岛大学健康科学研究科）；Strategy Office, Information & Communications, Nagoya University（名古屋大学信息与通信战略办公室）
Qier Meng, Takayuki Kitasaka, Masahiro Oda, Junji Ueno, Kensaku Mori
Some lung diseases are related to bronchial airway structures and morphology. Although airway segmentation from chest CT volumes is an important task in the computer-aided diagnosis and surgery assistance systems for the chest, complete 3-D airway structure segmentation is a quite challenging task due to its complex tree-like structure. In this paper, we propose a new airway segmentation method from 3D chest CT volumes based on volume of interests (VOI) using gradient vector flow (GVF). This method segments the bronchial regions by applying the cavity enhancement filter (CEF) to trace the bronchial tree structure from the trachea. It uses the CEF in the VOI to segment each branch. And a tube-likeness function based on GVF and the GVF magnitude map in each VOI are utilized to assist predicting the positions and directions of child branches. By calculating the tube-likeness function based on GVF and the GVF magnitude map, the airway-like candidate structures are identified and their centrelines are extracted. Based on the extracted centrelines, we can detect the branch points of the bifurcations and directions of the airway branches in the next level. At the same time, a leakage detection is performed to avoid the leakage by analysing the pixel information and the shape information of airway candidate regions extracted in the VOI. Finally, we unify all of the extracted bronchial regions to form an integrated airway tree. Preliminary experiments using four cases of chest CT volumes demonstrated that the proposed method can extract more bronchial branches in comparison with other methods.
Erasmus MC（伊拉斯谟大学医学中心）；Erasmus MC-Sophia Children Hospital（伊拉斯谟大学医学中心-索菲亚儿童医院）；University of Copenhagen（哥本哈根大学）
Segmentation of the airway tree from chest computed tomography (CT) images is critical for quantitative assessment of airway diseases including bronchiectasis and chronic obstructive pulmonary disease (COPD). However, obtaining an accurate segmentation of airways from CT scans is difficult due to the high complexity of airway structures. Recently, deep convolutional neural networks (CNNs) have become the state-of-the-art for many segmentation tasks, and in particular the so-called Unet architecture for biomedical images. However, its application to the segmentation of airways still remains a c…
Delft University of Technology（代尔夫特理工大学）；Erasmus Medical Center - Sophia Children’s Hospital（伊拉斯谟医学中心-索菲亚儿童医院）；Erasmus Medical Center（伊拉斯谟医学中心）；University of Copenhagen（哥本哈根大学）
Measuring airways in chest computed tomography (CT) images is important for characterizing diseases such as cystic fibrosis, yet very time-consuming to perform manually. Machine learning algorithms offer an alternative, but need large sets of annotated data to perform well. We investigate whether crowdsourcing can be used to gather airway annotations which can serve directly for measuring the airways, or as training data for the algorithms. We generate image slices at known locations of airways and request untrained crowd workers to outline the airway lumen and airway wall. Our results show th…
Eindhoven University of Technology（埃因霍温理工大学）；Erasmus MC - University Medical Center Rotterdam（伊拉斯谟医学中心-鹿特丹大学医学中心）；Erasmus MC - Sophia Children’s Hospital（伊拉斯谟医学中心-索菲亚儿童医院）；University of Copenhagen（哥本哈根大学）
Measuring airways in chest computed tomography (CT) scans is important for characterizing diseases such as cystic fibrosis, yet very time-consuming to perform manually. Machine learning algorithms offer an alternative, but need large sets of annotated scans for good performance. We investigate whether crowdsourcing can be used to gather airway annotations. We generate image slices at known locations of airways in 24 subjects and request the crowd workers to outline the airway lumen and airway wall. After combining multiple crowd workers, we compare the measurements to those made by the experts…
Brigham and Women’s Hospital（布莱根妇女医院）；Harvard Medical School（哈佛医学院）
Accurately and precisely characterizing the morphology of small pulmonary structures from Computed Tomography (CT) images, such as airways and vessels, is becoming of great importance for diagnosis of pulmonary diseases. The smaller conducting airways are the major site of increased airflow resistance in chronic obstructive pulmonary disease (COPD), while accurately sizing vessels can help identify arterial and venous changes in lung regions that may determine future disorders. However, traditional methods are often limited due to image resolution and artifacts. We propose a Convolutional Neur…
RepAir: A Framework for Airway Segmentation and Discontinuity Correction in CT
University of Michigan（密歇根大学）；D Medical, Inc.（4D医疗公司）；University of Massachusetts（马萨诸塞大学）；Emory University（埃默里大学）；Georgia Institute of Technology（佐治亚理工学院）
University of Science and Technology of China（中国科学技术大学）；School of Biomedical Engineering（生物医学工程学院）；Naval Medical University（海军军医大学）；Second Affiliated Hospital（第二附属医院）；Suzhou Aerospace Information Research Institute（苏州航天信息研究院）
Erasmus MC（伊拉斯姆斯医学中心）；Erasmus MC-Sophia Children Hospital（伊拉斯姆斯医学中心索菲亚儿童医院）；University of Copenhagen（哥本哈根大学）；Herlev-Gentofte Hospital, Copenhagen University Hospital（哥本哈根大学医院海尔鲁夫-根措夫特医院）
We present an end-to-end deep learning segmentation method by combining a 3D UNet architecture with a graph neural network (GNN) model. In this approach, the convolutional layers at the deepest level of the UNet are replaced by a GNN-based module with a series of graph convolutions. The dense feature maps at this level are transformed into a graph input to the GNN module. The incorporation of graph convolutions in the UNet provides nodes in the graph with information that is based on node connectivity, in addition to the local features learnt through the downsampled paths. This information can…
Shanghai Jiao Tong University（上海交通大学）；Imperial College London（帝国理工学院）
Airway segmentation on CT scans is critical for pulmonary disease diagnosis and endobronchial navigation. Manual extraction of airway requires strenuous efforts due to the complicated structure and various appearance of airway. For automatic airway extraction, convolutional neural networks (CNNs) based methods have recently become the state-of-the-art approach. However, there still remains a challenge for CNNs to perceive the tree-like pattern and comprehend the connectivity of airway. To address this, we propose a voxel-connectivity aware approach named AirwayNet for accurate airway segmentat…
Sichuan University - Pittsburgh Institute（四川大学-匹兹堡学院）
Airway segmentation from chest computed tomography scans has played an essential role in the pulmonary disease diagnosis. The computer-assisted airway segmentation based on the U-net architecture is more efficient and accurate compared to the manual segmentation. In this paper we employ the U$^2$-net trained by the Dice loss function to model the airway tree from the multi-site CT scans based on 299 training CT scans provided by the ATM'22. The derived saliency probability map from the training is applied to the validation data to extract the corresponding airway trees. The observation shows t…
Airway segmentation in computed tomography images can be used to analyze pulmonary diseases, however, manual segmentation is labor intensive and relies on expert knowledge. This manuscript details our contribution to MICCAI's 2022 Airway Tree Modelling challenge, a competition of fully automated methods for airway segmentation. We employed a previously developed deep learning architecture based on a modified EfficientDet (MEDSeg), training from scratch for binary airway segmentation using the provided annotations. Our method achieved 90.72 Dice in internal validation, 95.52 Dice on external va…
Institute of Medical Robotics, Shanghai Jiao Tong University（上海交通大学医疗机器人研究所）；Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University（上海交通大学图像处理与模式识别研究所）
Purpose: Bronchoscopic intervention is a widely-used clinical technique for pulmonary diseases, which requires an accurate and topological complete airway map for its localization and guidance. The airway map could be extracted from chest computed tomography (CT) scans automatically by airway segmentation methods. Due to the complex tree-like structure of the airway, preserving its topology completeness while maintaining the segmentation accuracy is a challenging task. Methods: In this paper, a long-term slice propagation (LTSP) method is proposed for accurate airway segmentation from patholog…
Airway Segmentation Network for Enhanced Tubular Feature Extraction
School of Optical-electrical and Computer Engineering（光学电子与计算机工程学院）；University of Shanghai for Science and Technology（上海理工大学）；School of Information Technology（信息技术学院）；Jiangsu Open University（江苏开放大学）
In this research project, we put forward an advanced method for airway segmentation based on the existent convolutional neural network (CNN) and graph neural network (GNN). The method is originated from the vessel segmentation, but we ameliorate it and enable the novel model to perform better for datasets from computed tomography (CT) scans. Current methods for airway segmentation are considering the regular grid only. No matter what the detailed model is, including the 3-dimensional CNN or 2-dimensional CNN in three directions, the overall graph structures are not taken into consideration. In…
University College London（伦敦大学学院）；The Royal Free Hospital（皇家自由医院）；University of Cyprus（塞浦路斯大学）
Bronchiectasis is the permanent dilation of airways. Patients with the disease can suffer recurrent exacerbations, reducing their quality of life. The gold standard to diagnose and monitor bronchiectasis is accomplished by inspection of chest computed tomography (CT) scans. A clinician examines the broncho-arterial ratio to determine if an airway is brochiectatic. The visual analysis assumes the blood vessel diameter remains constant, although this assumption is disputed in the literature. We propose a simple measurement of tapering along the airways to diagnose and monitor bronchiectasis. To …
School of Mechanical engineering and Automation, Fuzhou University（福州大学机械工程及自动化学院）；School of Physics and Information Engineering, Fuzhou University（福州大学物理与信息工程学院）；Thoracic Department, Fujian Medical University Union Hospital（福建医科大学附属协和医院胸外科）
Automatic airway segmentation from chest computed tomography (CT) scans plays an important role in pulmonary disease diagnosis and computer-assisted therapy. However, low contrast at peripheral branches and complex tree-like structures remain as two mainly challenges for airway segmentation. Recent research has illustrated that deep learning methods perform well in segmentation tasks. Motivated by these works, a coarse-to-fine segmentation framework is proposed to obtain a complete airway tree. Our framework segments the overall airway and small branches via the multi-information fusion convol…
National Heart and Lung Institute, Imperial College London（帝国理工学院国家心肺研究所）；Imperial College London（帝国理工学院）；Royal Brompton Hospital（皇家布朗普顿医院）
Discontinuity in the delineation of peripheral bronchioles hinders the potential clinical application of automated airway segmentation models. Moreover, the deployment of such models is limited by the data heterogeneity across different centres, and pathological abnormalities also make achieving accurate robust segmentation in distal small airways difficult. Meanwhile, the diagnosis and prognosis of lung diseases often rely on evaluating structural changes in those anatomical regions. To address this gap, this paper presents a patch-scale adversarial-based refinement network that takes in prel…
Northeastern University（东北大学）；Shenyang University of Technology（沈阳工业大学）；The Chinese University of Hong Kong（香港中文大学）；Second Affiliated Hospital of Dalian Medical University（大连医科大学附属第二医院）；Central Hospital Affiliated to Shenyang Medical College（沈阳医学院附属中心医院）
Accurate airway extraction from computed tomography (CT) images is a critical step for planning navigation bronchoscopy and quantitative assessment of airway-related chronic obstructive pulmonary disease (COPD). The existing methods are challenging to sufficiently segment the airway, especially the high-generation airway, with the constraint of the limited label and cannot meet the clinical use in COPD. We propose a novel two-stage 3D contextual transformer-based U-Net for airway segmentation using CT images. The method consists of two stages, performing initial and refined airway segmentation…
Topology-Aware Wavelet Mamba for Airway Structure Segmentation in Postoperative Recurrent Nasopharyngeal Carcinoma CT Scans
School of Software Engineering, Sun Yat-sen University（中山大学软件工程学院）；School of Microelectronics, Shanghai University（上海大学微电子学院）；Electronic and Computer Engineering, The Hong Kong University of Science and Technology（香港科技大学电子与计算机工程系）；Ruijin Hospital, Shanghai Jiao Tong University School of Medicine（上海交通大学医学院附属瑞金医院）；Eye & ENT Hospital, Fudan University（复旦大学附属眼耳鼻喉科医院）
Erasmus MC（伊拉斯姆斯医学中心）；Erasmus MC-Sophia Children Hospital（伊拉斯姆斯医学中心索菲亚儿童医院）；University of Copenhagen（哥本哈根大学）；Copenhagen University Hospital（哥本哈根大学医院）；Herlev-Gentofte Hospital（海莱乌-根措夫特医院）
This paper presents a fully automatic and end-to-end optimised airway segmentation method for thoracic computed tomography, based on the U-Net architecture. We use a simple and low-memory 3D U-Net as backbone, which allows the method to process large 3D image patches, often comprising full lungs, in a single pass through the network. This makes the method simple, robust and efficient. We validated the proposed method on three datasets with very different characteristics and various airway abnormalities: i) a dataset of pediatric patients including subjects with cystic fibrosis, ii) a subset of…
Institute of Medical Robotics, Shanghai Jiao Tong University（上海交通大学医疗机器人研究院）；Shanghai Chest Hospital（上海市胸科医院）；Shanghai Engineering Research Center of Respiratory Endoscopy（上海市呼吸内镜工程技术研究中心）
Automated airway segmentation is a prerequisite for pre-operative diagnosis and intra-operative navigation for pulmonary intervention. Due to the small size and scattered spatial distribution of peripheral bronchi, this is hampered by severe class imbalance between foreground and background regions, which makes it challenging for CNN-based methods to parse distal small airways. In this paper, we demonstrate that this problem is arisen by gradient erosion and dilation of the neighborhood voxels. During back-propagation, if the ratio of the foreground gradient to background gradient is small whi…
Automated segmentation of Lungs plays a crucial role in the computer-aided diagnosis of chest X-Ray (CXR) images. Developing an efficient Lung segmentation model is challenging because of difficulties such as the presence of several edges at the rib cage and clavicle, inconsistent lung shape among different individuals, and the appearance of the lung apex. In this paper, we propose a robust model for Lung segmentation in Chest Radiographs. Our model learns to ignore the irrelevant regions in an input Chest Radiograph while highlighting regions useful for lung segmentation. The proposed model i…
Progressive Curriculum Learning with Scale-Enhanced U-Net for Continuous Airway Segmentation
Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）；School of Artificial Intelligence, University of Chinese Academy of Sciences（中国科学院大学人工智能学院）；The First Affiliated Hospital of Sun Yat-sen University（中山大学附属第一医院）；Centre of AI and Robotics, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences（中国科学院香港创新研究院人工智能与机器人中心）；School of Biomedical Engineering and Imaging Sciences, King’s College London（伦敦国王学院生物医学工程与影像科学学院）
We present a novel graph-based approach for labeling the anatomical branches of a given airway tree segmentation. The proposed method formulates airway labeling as a branch classification problem in the airway tree graph, where branch features are extracted using convolutional neural networks (CNN) and enriched using graph neural networks. Our graph neural network is structure-aware by having each node aggregate information from its local neighbors and position-aware by encoding node positions in the graph. We evaluated the proposed method on 220 airway trees from subjects with various severit…
Institute of Medical Robotics, Shanghai Jiao Tong University（上海交通大学医疗机器人研究院）；Medical Image Centre, The First Affiliated Hospital of Jinan University（暨南大学附属第一医院医学影像中心）；Department of Computer Science and Software Engineering, Swinburne University of Technology（斯威本科技大学计算机科学与软件工程系）；Shanghai Center for Brain Science and Brain-Inspired Technology（上海脑科学与类脑研究中心）
3D Convolutional Neural Networks (CNNs) have been widely adopted for airway segmentation. The performance of 3D CNNs is greatly influenced by the dataset while the public airway datasets are mainly clean CT scans with coarse annotation, thus difficult to be generalized to noisy CT scans (e.g. COVID-19 CT scans). In this work, we proposed a new dual-stream network to address the variability between the clean domain and noisy domain, which utilizes the clean CT scans and a small amount of labeled noisy CT scans for airway segmentation. We designed two different encoders to extract the transferab…
National Heart and Lung Institute, Imperial College London（帝国理工学院国家心肺研究所）；University of the Basque Country UPV/EHU（巴斯克大学（UPV/EHU））；TECNALIA, Basque Research and Technology Alliance (BRTA)（巴斯克研究与技术联盟（BRTA）泰克纳利亚研究中心）；Technical University of Munich（慕尼黑工业大学）；King Abdulaziz University（阿卜杜勒阿齐兹国王大学）；University of Alberta（阿尔伯塔大学）；The Systems Research Institute, Polish Academy of Sciences（波兰科学院系统研究所）；Royal Brompton Hospital（皇家布朗普顿医院）
Airway segmentation is crucial for the examination, diagnosis, and prognosis of lung diseases, while its manual delineation is unduly burdensome. To alleviate this time-consuming and potentially subjective manual procedure, researchers have proposed methods to automatically segment airways from computerized tomography (CT) images. However, some small-sized airway branches (e.g., bronchus and terminal bronchioles) significantly aggravate the difficulty of automatic segmentation by machine learning models. In particular, the variance of voxel values and the severe data imbalance in airway branch…
Multi-site, Multi-domain Airway Tree Modeling (ATM'22): A Public Benchmark for Pulmonary Airway Segmentation
Shanghai Jiao Tong University（上海交通大学）；InferVision Medical Technology Co., Ltd.（推想医疗科技股份有限公司）；University of California, Los Angeles（加州大学洛杉矶分校）；Imperial College London（帝国理工学院）
University of Copenhagen（哥本哈根大学）；Rigshospitalet, University Hospital of Copenhagen（哥本哈根大学医院）；Erasmus MC（伊拉斯谟医学中心）
Segmenting tree structures is common in several image processing applications. In medical image analysis, reliable segmentations of airways, vessels, neurons and other tree structures can enable important clinical applications. We present a framework for tracking tree structures comprising of elongated branches using probabilistic state-space models and Bayesian smoothing. Unlike most existing methods that proceed with sequential tracking of branches, we present an exploratory method, that is less sensitive to local anomalies in the data due to acquisition noise and/or interfering structures. …
Institute of Medical Robotics, Shanghai Jiao Tong University（上海交通大学医学机器人研究所）；School of Computer Science and Technology, Guizhou University（贵州大学计算机科学与技术学院）；Shanghai Chest Hospital, Shanghai Jiao Tong University（上海交通大学附属胸科医院）；Université de Lyon, INSA Lyon, CREATIS, CNRS, INSERM（里昂大学、里昂国立应用科学学院、CREATIS实验室、法国国家科学研究中心、法国国家健康与医学研究院）
Training convolutional neural networks (CNNs) for segmentation of pulmonary airway, artery, and vein is challenging due to sparse supervisory signals caused by the severe class imbalance between tubular targets and background. We present a CNNs-based method for accurate airway and artery-vein segmentation in non-contrast computed tomography. It enjoys superior sensitivity to tenuous peripheral bronchioles, arterioles, and venules. The method first uses a feature recalibration module to make the best use of features learned from the neural networks. Spatial information of features is properly i…
Deep Convolutional Neural Networks have proven effective in solving the task of semantic segmentation. However, their efficiency heavily relies on the pixel-level annotations that are expensive to get and often require domain expertise, especially in medical imaging. Weakly supervised semantic segmentation helps to overcome these issues and also provides explainable deep learning models. In this paper, we propose a novel approach to the semantic segmentation of medical chest X-ray images with only image-level class labels as supervision. We improve the disease localization accuracy by combinin…
Chest X-ray (CXR) is one of the most commonly prescribed medical imaging procedures, often with over 2-10x more scans than other imaging modalities such as MRI, CT scan, and PET scans. These voluminous CXR scans place significant workloads on radiologists and medical practitioners. Organ segmentation is a crucial step to obtain effective computer-aided detection on CXR. In this work, we propose Structure Correcting Adversarial Network (SCAN) to segment lung fields and the heart in CXR images. SCAN incorporates a critic network to impose on the convolutional segmentation network the structural …
Deep Learning-Based Airway Segmentation in Systemic Lupus Erythematosus Patients with Interstitial Lung Disease (SLE-ILD): A Comparative High-Resolution CT Analysis
Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College（放射科，北京地坛医院，中国医学科学院与北京联合医学院）；Research and Development Center (RDC), Canon Medical Systems (China)（研发部（RDC），佳能医疗系统（中国））；Canon Medical Systems (China)（佳能医疗系统（中国））
Predicting Patient Survival with Airway Biomarkers using nn-Unet/Radiomics
Normandie Univ., INSA Rouen, LITIS, 76801, Saint Etienne du Rouvray, France（诺曼底大学）；Normandie Univ., UNICAEN, ENSICAEN, CNRS, GREYC, 14000 Caen, France（诺曼底大学）；Nuclear Medicine Department, Henri Becquerel Cancer Center, Rouen, France（贝克勒尔癌症中心核医学部）；Radiotherapy Department, Henri Becquerel Cancer Center, Rouen, France（贝克勒尔癌症中心放射治疗部）；Siemens Healthineers（西门子医疗）
National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）；Ping An Insurance Company of China（中国平安保险（集团）股份有限公司）
This paper proposes a novel framework for lung segmentation in chest X-rays. It consists of two key contributions, a criss-cross attention based segmentation network and radiorealistic chest X-ray image synthesis (i.e. a synthesized radiograph that appears anatomically realistic) for data augmentation. The criss-cross attention modules capture rich global contextual information in both horizontal and vertical directions for all the pixels thus facilitating accurate lung segmentation. To reduce the manual annotation burden and to train a robust lung segmentor that can be adapted to pathological…
The Chinese University of Hong Kong（香港中文大学）；Imsight Medical Technology Inc.（艾迈医疗科技有限公司）
In spite of the compelling achievements that deep neural networks (DNNs) have made in medical image computing, these deep models often suffer from degraded performance when being applied to new test datasets with domain shift. In this paper, we present a novel unsupervised domain adaptation approach for segmentation tasks by designing semantic-aware generative adversarial networks (GANs). Specifically, we transform the test image into the appearance of source domain, with the semantic structural information being well preserved, which is achieved by imposing a nested adversarial learning in se…
Open University of Israel（以色列开放大学）；University of Chemistry and Technology in Prague（布拉格化学技术大学）
Although the field of sleep study has greatly developed over the recent years, the most common and efficient way to detect sleep issues remains a sleep examination performed in a sleep laboratory, in a procedure called Polysomnography (PSG). This examination measures several vital signals during a full night's sleep using multiple sensors connected to the patient's body. Yet, despite being the golden standard, the connection of the sensors and the unfamiliar environment inevitably impact the quality of the patient's sleep and the examination itself. Therefore, with the novel development of mor…
Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s National Health System（儿童国家卫生系统谢赫扎耶德儿科外科创新研究所）；Children’s National Health System（儿童国家卫生系统）；San Francisco State University（旧金山州立大学）；School of Medicine and Health Sciences, George Washington University（乔治华盛顿大学医学与健康科学学院）
Computer-aided diagnosis (CAD) techniques for lung field segmentation from chest radiographs (CXR) have been proposed for adult cohorts, but rarely for pediatric subjects. Statistical shape models (SSMs), the workhorse of most state-of-the-art CXR-based lung field segmentation methods, do not efficiently accommodate shape variation of the lung field during the pediatric developmental stages. The main contributions of our work are: (1) a generic lung field segmentation framework from CXR accommodating large shape variation for adult and pediatric cohorts; (2) a deep representation learning dete…
Image Sciences Institute（影像科学研究所）；University Medical Center Utrecht（乌得勒支大学医学中心）
Morphological analysis and identification of pathologies in the aorta are important for cardiovascular diagnosis and risk assessment in patients. Manual annotation is time-consuming and cumbersome in CT scans acquired without contrast enhancement and with low radiation dose. Hence, we propose an automatic method to segment the ascending aorta, the aortic arch and the thoracic descending aorta in low-dose chest CT without contrast enhancement. Segmentation was performed using a dilated convolutional neural network (CNN), with a receptive field of 131X131 voxels, that classified voxels in axial,…
Rutgers University（罗格斯大学）；Thomas Jefferson University（托马斯杰斐逊大学）
The purpose of this study is to develop an automated algorithm for thoracic vertebral segmentation on chest radiography using deep learning. 124 de-identified lateral chest radiographs on unique patients were obtained. Segmentations of visible vertebrae were manually performed by a medical student and verified by a board-certified radiologist. 74 images were used for training, 10 for validation, and 40 were held out for testing. A U-Net deep convolutional neural network was employed for segmentation, using the sum of dice coefficient and binary cross-entropy as the loss function. On the test s…
Universitat de Girona（赫罗纳大学）；Université de Bourgogne（勃艮第大学）；Università degli studi di Cassino（卡西诺大学）；Duke University School of Medicine（杜克大学医学院）；Duke University（杜克大学）
Weakly supervised disease classification of CT imaging suffers from poor localization owing to case-level annotations, where even a positive scan can hold hundreds to thousands of negative slices along multiple planes. Furthermore, although deep learning segmentation and classification models extract distinctly unique combinations of anatomical features from the same target class(es), they are typically seen as two independent processes in a computer-aided diagnosis (CAD) pipeline, with little to no feature reuse. In this research, we propose a medical classifier that leverages the semantic st…
University of Pittsburgh（匹兹堡大学）；Tangdu Hospital（唐都医院）
This study aims to automatically diagnose thoracic diseases depicted on the chest x-ray (CXR) images using deep convolutional neural networks. The existing methods generally used the entire CXR images for training purposes, but this strategy may suffer from two drawbacks. First, potential misalignment or the existence of irrelevant objects in the entire CXR images may cause unnecessary noise and thus limit the network performance. Second, the relatively low image resolution caused by the resizing operation, which is a common preprocessing procedure for training neural networks, may lead to the…
National Library of Medicine（国家医学图书馆）；National Institutes of Health（美国国立卫生研究院）；Saint Louis University（圣路易斯大学）
Deep learning (DL) has drawn tremendous attention in object localization and recognition for both natural and medical images. U-Net segmentation models have demonstrated superior performance compared to conventional handcrafted feature-based methods. Medical image modality-specific DL models are better at transferring domain knowledge to a relevant target task than those that are pretrained on stock photography images. This helps improve model adaptation, generalization, and class-specific region of interest (ROI) localization. In this study, we train chest X-ray (CXR) modality-specific U-Nets…
Wayne State Univ.（韦恩州立大学）；NanoBioScience Institute, Wayne State Univ.（韦恩州立大学纳米生物科学研究所）；University of Michigan（密歇根大学）；Henry Ford Health System（亨利福特医疗系统）
Deep Neural Networks (DNN) are widely used to carry out segmentation tasks in biomedical images. Most DNNs developed for this purpose are based on some variation of the encoder-decoder U-Net architecture. Here we show that Res-CR-Net, a new type of fully convolutional neural network, which was originally developed for the semantic segmentation of microscopy images, and which does not adopt a U-Net architecture, is very effective at segmenting the lung fields in chest X-rays from either healthy patients or patients with a variety of lung pathologies.
