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arXiv 1612.01403stat.MEstat.AP
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系统医学中先验估计的经验贝叶斯方法

Empirical Bayes Methods for Prior Estimation in Systems Medicine

Ilja Klebanov, Alexander Sikorski, Christof Schütte, Susanna Röblitz

摘要:

在与医疗应用相关的系统医学中,数学建模的主要目标之一是获得患者特定的参数化和模型预测。然而,在临床实践中,由于时间和成本的限制,单个患者的可用测量数量通常是有限的。这阻碍了对治疗结果进行患者特异性预测的过程。另一方面,许多患者的数据通常是可用的,特别是如果已经进行了广泛的临床研究。因此,在将贝叶斯规则\emph{separately}应用于每个患者的数据(通常使用非信息先验进行)之前,使用经验贝叶斯方法以便从所有可用数据构建信息先验是有意义的。我们比较了四种先验的性能--非信息先验和由非参数极大似然估计(NPMLE)、最大惩罚似然估计(MPLE)和双平滑极大似然估计(DS-MLE)选择的先验--通过将它们应用于玩具模型中的低维参数估计问题以及人类月经周期的高维ODE模型,这是系统生物学建模的一个典型例子。

英文摘要:

One of the main goals of mathematical modeling in systems medicine related to medical applications is to obtain patient-specific parameterizations and model predictions. In clinical practice, however, the number of available measurements for single patients is usually limited due to time and cost restrictions. This hampers the process of making patient-specific predictions about the outcome of a treatment. On the other hand, data are often available for many patients, in particular if extensive clinical studies have been performed. Therefore, before applying Bayes' rule \emph{separately} to the data of each patient (which is typically performed using a non-informative prior), it is meaningful to use empirical Bayes methods in order to construct an informative prior from all available data. We compare the performance of four priors -- a non-informative prior and priors chosen by nonparametric maximum likelihood estimation (NPMLE), by maximum penalized likelihood estimation (MPLE) and by doubly-smoothed maximum likelihood estimation (DS-MLE) -- by applying them to a low-dimensional parameter estimation problem in a toy model as well as to a high-dimensional ODE model of the human menstrual cycle, which represents a typical example from systems biology modeling.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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