In this paper, a filtering approach for the 3D magnetic resonance imaging (MRI) assuming a Rician model for noise is addressed. Our denoising method is based on the Conventional Approach (CA) proposed to deal with the noise issue in the squared domain of the acquired magnitude MRI, where the noise distribution follows a Chi-square model rather than the Rician one. In the CA filtering method, the local samples around each voxel is used to estimate the unknown signal value. Intrinsically, such a method fails to achieve the best results where the underlying signal values have different statistical properties. On the contrary, our proposal takes advantage of the data redundancy and self-similarity properties of real MR images to improve the noise removal performance. In other words, in our approach, the statistical momentums of the given 3D MR volume are first calculated to explore the similar patches inside a defined search volume. Then, these patches are put together to obtain the noise-free value for each voxel under processing. The experimental results on the synthetic as well as the clinical MR data show our proposed method outperforms the other compared denoising filters.
Facebook AI Research(Facebook人工智能研究);Facebook New York(纽约Facebook);NYU Grossman School of Medicine(纽约大学格罗斯曼医学院);Department of Radiology(放射科)
MRI images reconstructed from sub-sampled Cartesian data using deep learning techniques often show a characteristic banding (sometimes described as streaking), which is particularly strong in low signal-to-noise regions of the reconstructed image. In this work, we propose the use of an adversarial loss that penalizes banding structures without requiring any human annotation. Our technique greatly reduces the appearance of banding, without requiring any additional computation or post-processing at reconstruction time. We report the results of a blind comparison against a strong baseline by a gr…
Retrospective artifact correction (RAC) improves image quality post acquisition and enhances image usability. Recent machine learning driven techniques for RAC are predominantly based on supervised learning and therefore practical utility can be limited as data with paired artifact-free and artifact-corrupted images are typically insufficient or even non-existent. Here we show that unwanted image artifacts can be disentangled and removed from an image via an RAC neural network learned with unpaired data. This implies that our method does not require matching artifact-corrupted data to be eithe…
Deep Learning Assisted Outer Volume Removal for Highly-Accelerated Real-Time Dynamic MRI
Department of Electrical and Computer Engineering, University of Minnesota(电气与计算机工程系,明尼苏达大学);Center for Magnetic Resonance Research, University of Minnesota(磁共振研究中心,明尼苏达大学);Department of Imaging Physics, Delft University of Technology(成像物理系,代尔夫特理工大学);HollandPTC, Delft, the Netherlands(HollandPTC,代尔夫特,荷兰)
KTH Royal Institute of Technology(KTH皇家理工学院);Science for Life Laboratory(生命科学实验室)
Artifacts on magnetic resonance scans are a serious challenge for both radiologists and computer-aided diagnosis systems. Most commonly, artifacts are caused by motion of the patients, but can also arise from device-specific abnormalities such as noise patterns. Irrespective of the source, artifacts can not only render a scan useless, but can potentially induce misdiagnoses if left unnoticed. For instance, an artifact may masquerade as a tumor or other abnormality. Retrospective artifact correction (RAC) is concerned with removing artifacts after the scan has already been taken. In this work, …
Charité – Universitätsmedizin Berlin(柏林夏里特医学院);Freie Universität Berlin(柏林自由大学);Humboldt-Universität zu Berlin(柏林洪堡大学);Berlin Institute of Health(柏林健康研究所)
Machine learning-based imaging diagnostics has recently reached or even superseded the level of clinical experts in several clinical domains. However, classification decisions of a trained machine learning system are typically non-transparent, a major hindrance for clinical integration, error tracking or knowledge discovery. In this study, we present a transparent deep learning framework relying on convolutional neural networks (CNNs) and layer-wise relevance propagation (LRP) for diagnosing multiple sclerosis (MS). MS is commonly diagnosed utilizing a combination of clinical presentation and …
From Pre- to Intra-operative MRI: Predicting Brain Shift in Temporal Lobe Resection for Epilepsy Surgery
Surgical and Interventional Engineering(外科与介入工程);King’s College London(伦敦国王学院);National Hospital for Neurology and Neurosurgery(神经外科医院);NHS(国家健康服务);Neurosurgery, King’s College Hospital(神经外科,伦敦国王学院医院);Fondazione IRCCS Ca’ Granda(IRCCS Ca’ Granda基金会);Ospedale Maggiore di Milano(米兰大医院)
Quantitative mapping from conventional MRI using self-supervised physics-guided deep learning: applications to a large-scale, clinically heterogeneous dataset
In multi-contrast magnetic resonance imaging (MRI), compressed sensing theory can accelerate imaging by sampling fewer measurements within each contrast. The conventional optimization-based models suffer several limitations: strict assumption of shared sparse support, time-consuming optimization and "shallow" models with difficulties in encoding the rich patterns hiding in massive MRI data. In this paper, we propose the first deep learning model for multi-contrast MRI reconstruction. We achieve information sharing through feature sharing units, which significantly reduces the number of paramet…
Convolutional neural networks (CNNs) have been applied to various automatic image segmentation tasks in medical image analysis, including brain MRI segmentation. Generative adversarial networks have recently gained popularity because of their power in generating images that are difficult to distinguish from real images. In this study we use an adversarial training approach to improve CNN-based brain MRI segmentation. To this end, we include an additional loss function that motivates the network to generate segmentations that are difficult to distinguish from manual segmentations. During traini…
Dalian University of Technology(大连理工大学);Hangzhou Dianzi University(杭州电子科技大学);Guilin University of Electronic Technology(桂林电子科技大学)
Compressed Sensing Magnetic Resonance Imaging (CS-MRI) significantly accelerates MR data acquisition at a sampling rate much lower than the Nyquist criterion. A major challenge for CS-MRI lies in solving the severely ill-posed inverse problem to reconstruct aliasing-free MR images from the sparse k-space data. Conventional methods typically optimize an energy function, producing reconstruction of high quality, but their iterative numerical solvers unavoidably bring extremely slow processing. Recent data-driven techniques are able to provide fast restoration by either learning direct prediction…
Compressed sensing has shown great potential in reducing data acquisition time in magnetic resonance imaging (MRI). Recently, a spread spectrum compressed sensing MRI method modulates an image with a quadratic phase. It performs better than the conventional compressed sensing MRI with variable density sampling, since the coherence between the sensing and sparsity bases are reduced. However, spread spectrum in that method is implemented via a shim coil which limits its modulation intensity and is not convenient to operate. In this letter, we propose to apply chirp (linear frequency-swept) radio…
WASABI: A Metric for Evaluating Morphometric Plausibility of Synthetic Brain MRIs
Department of Radiology, Weill Cornell Medicine, New York, NY, USA(放射科,韦尔·科恩医学中心,纽约,纽约州,美国);Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA(精神病学与行为科学系,斯坦福大学,斯坦福,加利福尼亚州,美国);Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY, USA(电气与计算机工程系,康奈尔大学,伊萨卡,纽约州,美国)
United Imaging Intelligence(联影智能);UIH America, Inc.(联影美国公司);United Imaging Healthcare(联影医疗)
Retrospectively gated cine (retro-cine) MRI is the clinical standard for cardiac functional analysis. Deep learning (DL) based methods have been proposed for the reconstruction of highly undersampled MRI data and show superior image quality and magnitude faster reconstruction time than CS-based methods. Nevertheless, it remains unclear whether DL reconstruction is suitable for cardiac function analysis. To address this question, in this study we evaluate and compare the cardiac functional values (EDV, ESV and EF for LV and RV, respectively) obtained from highly accelerated MRI acquisition usin…
Technische Universität München(慕尼黑工业大学);University of Edinburgh(爱丁堡大学);University of Sheffield(谢菲尔德大学)
Dynamic contrast-enhanced (DCE) MRI is an evolving imaging technique that provides a quantitative measure of pharmacokinetic (PK) parameters in body tissues, in which series of T1-weighted images are collected following the administration of a paramagnetic contrast agent. Unfortunately, in many applications, conventional clinical DCE-MRI suffers from low spatiotemporal resolution and insufficient volume coverage. In this paper, we propose a novel deep learning based approach to directly estimate the PK parameters from undersampled DCE-MRI data. Specifically, we design a custom loss function wh…
University of Bath(巴斯大学);Technical University of Munich(慕尼黑工业大学);GE Healthcare(通用电气医疗集团);Technische Hochschule Ingolstadt(英戈尔施塔特应用技术大学)
Current spatiotemporal deep learning approaches to Magnetic Resonance Fingerprinting (MRF) build artefact-removal models customised to a particular k-space subsampling pattern which is used for fast (compressed) acquisition. This may not be useful when the acquisition process is unknown during training of the deep learning model and/or changes during testing time. This paper proposes an iterative deep learning plug-and-play reconstruction approach to MRF which is adaptive to the forward acquisition process. Spatiotemporal image priors are learned by an image denoiser i.e. a Convolutional Neura…
CPT-4DMR: Continuous sPatial-Temporal Representation for 4D-MRI Reconstruction
Center for Proton Therapy, Paul Scherrer Institut(质子治疗中心,保罗·施特格勒研究所);Department of Physics, ETH Zurich(苏黎世联邦理工学院物理系);Department of Computer Science, ETH Zurich(苏黎世联邦理工学院计算机科学系);Department of Radiology, Division of Radiological Physics, University Hospital Basel(巴塞尔大学医院放射科,放射物理 division);Department of Biomedical Engineering, University of Basel(巴塞尔大学生物医学工程系);Institute for Biomedical Engineering, University and ETH Zurich(生物医学工程研究所,大学与苏黎世联邦理工学院)
Sun Yat-sen University(中山大学);The Chinese University of Hong Kong(香港中文大学);Royal Brompton Hospital(皇家布朗普顿医院);Imperial College London(伦敦帝国理工学院)
The long acquisition time has limited the accessibility of magnetic resonance imaging (MRI) because it leads to patient discomfort and motion artifacts. Although several MRI techniques have been proposed to reduce the acquisition time, compressed sensing in magnetic resonance imaging (CS-MRI) enables fast acquisition without compromising SNR and resolution. However, existing CS-MRI methods suffer from the challenge of aliasing artifacts. This challenge results in the noise-like textures and missing the fine details, thus leading to unsatisfactory reconstruction performance. To tackle this chal…
Fast data acquisition in Magnetic Resonance Imaging (MRI) is vastly in demand and scan time directly depends on the number of acquired k-space samples. The data-driven methods based on deep neural networks have resulted in promising improvements, compared to the conventional methods, in image reconstruction algorithms. The connection between deep neural network and Ordinary Differential Equation (ODE) has been observed and studied recently. The studies show that different residual networks can be interpreted as Euler discretization of an ODE. In this paper, we propose an ODE-based deep network…
Monash Biomedical Imaging, Monash University(莫纳什大学生物医学成像中心);Department of Electrical and Computer Systems Engineering, Monash University(莫纳什大学电气与计算机系统工程系);School of Psychological Sciences, Monash University(莫纳什大学心理科学学院);Department of Data Science and AI, Monash University(莫纳什大学数据科学与人工智能系)
Global correlations are widely seen in human anatomical structures due to similarity across tissues and bones. These correlations are reflected in magnetic resonance imaging (MRI) scans as a result of close-range proton density and T1/T2 parameters. Furthermore, to achieve accelerated MRI, k-space data are undersampled which causes global aliasing artifacts. Convolutional neural network (CNN) models are widely utilized for accelerated MRI reconstruction, but those models are limited in capturing global correlations due to the intrinsic locality of the convolution operation. The self-attention-…
Harvard Medical School(哈佛医学院);Boston Children’s Hospital(波士顿儿童医院)
Fast data acquisition in Magnetic Resonance Imaging (MRI) is vastly in demand and scan time directly depends on the number of acquired k-space samples. Conventional MRI reconstruction methods for fast MRI acquisition mostly relied on different regularizers which represent analytical models of sparsity. However, recent data-driven methods based on deep learning has resulted in promising improvements in image reconstruction algorithms. In this paper, we propose a deep plug-and-play prior framework for parallel MRI reconstruction problems which utilize a deep neural network (DNN) as an advanced d…
A Review of Electromagnetic Elimination Methods for low-field portable MRI scanner
Harvard Medical School(哈佛医学院);University of Michigan(密歇根大学);Harvard University(哈佛大学);New York University(纽约大学);Columbia University(哥伦比亚大学);Guangxi University(广西大学)
Erasmus MC(伊拉斯谟医学中心);Maastricht University Medical Center(马斯特里赫特大学医学中心);University Medical Center Groningen(格罗宁根大学医学中心);University Medical Center Utrecht(乌得勒支大学医学中心);Radboud University Medical Center(拉德堡德大学医学中心);Leiden University Medical Center(莱顿大学医学中心);Leiden University(莱顿大学)
This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive impairment (MCI). We used a conventional support vector machine (SVM) and a deep convolutional neural network (CNN) approach based on structural MRI scans that underwent either minimal pre-processing or more extensive pre-processing into modulated gray matter (GM) maps. Classifiers were optimized and evaluated using cross-validation in the ADNI (334 AD, 520 CN). Tr…
Imperial College London(帝国理工学院);Royal Brompton Hospital(皇家布朗普顿医院)
Segmentation of cardiac fibrosis and scar are essential for clinical diagnosis and can provide invaluable guidance for the treatment of cardiac diseases. Late Gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) has been successful for its efficacy in guiding the clinical diagnosis and treatment reliably. For LGE CMR, many methods have demonstrated success in accurately segmenting scarring regions. Co-registration with other non-contrast-agent (non-CA) modalities, balanced steady-state free precession (bSSFP) and cine magnetic resonance imaging (MRI) for example, can further en…
University of Minnesota(明尼苏达大学);Sungkyunkwan University(成均馆大学)
Recent studies show that deep learning (DL) based MRI reconstruction outperforms conventional methods, such as parallel imaging and compressed sensing (CS), in multiple applications. Unlike CS that is typically implemented with pre-determined linear representations for regularization, DL inherently uses a non-linear representation learned from a large database. Another line of work uses transform learning (TL) to bridge the gap between these two approaches by learning linear representations from data. In this work, we combine ideas from CS, TL and DL reconstructions to learn deep linear convol…
Netherlands Cancer Institute(荷兰癌症研究所);qurAI group(qurAI团队);University of Amsterdam(阿姆斯特丹大学)
Magnetic Resonance Imaging can produce detailed images of the anatomy and physiology of the human body that can assist doctors in diagnosing and treating pathologies such as tumours. However, MRI suffers from very long acquisition times that make it susceptible to patient motion artifacts and limit its potential to deliver dynamic treatments. Conventional approaches such as Parallel Imaging and Compressed Sensing allow for an increase in MRI acquisition speed by reconstructing MR images from sub-sampled MRI data acquired using multiple receiver coils. Recent advancements in Deep Learning combi…
The k-space data generated from magnetic resonance imaging (MRI) is only a finite sampling of underlying signals. Therefore, MRI images often suffer from low spatial resolution and Gibbs ringing artifacts. Previous studies tackled these two problems separately, where super resolution methods tend to enhance Gibbs artifacts, whereas Gibbs ringing removal methods tend to blur the images. It is also a challenge that high resolution ground truth is hard to obtain in clinical MRI. In this paper, we propose an unsupervised learning framework for both MRI super resolution and Gibbs artifacts removal …
MIT(麻省理工学院);Tsinghua University(清华大学);Boston Children’s Hospital(波士顿儿童医院);Harvard Medical School(哈佛医学院)
The performance and diagnostic utility of magnetic resonance imaging (MRI) in pregnancy is fundamentally constrained by fetal motion. Motion of the fetus, which is unpredictable and rapid on the scale of conventional imaging times, limits the set of viable acquisition techniques to single-shot imaging with severe compromises in signal-to-noise ratio and diagnostic contrast, and frequently results in unacceptable image quality. Surprisingly little is known about the characteristics of fetal motion during MRI and here we propose and demonstrate methods that exploit a growing repository of MRI ob…
Tel Aviv University(特拉维夫大学);Sheba Medical Center(示巴医疗中心)
Medical reports are an essential medium in recording a patient's condition throughout a clinical trial. They contain valuable information that can be extracted to generate a large labeled dataset needed for the development of clinical tools. However, the majority of medical reports are stored in an unregularized format, and a trained human annotator (typically a doctor) must manually assess and label each case, resulting in an expensive and time consuming procedure. In this work, we present a framework for developing a multilingual breast MRI report classifier using a custom-built language rep…
Model-based Dynamic 3D MRI Reconstructions using Neural Fields and Tensor Product Expansions
Computational Imaging Group for MRI Therapy & Diagnostics, Department of Radiotherapy, University Medical Center Utrecht(MRI治疗与诊断计算成像组,放射治疗系,乌得勒支大学医学中心)
Institute of Smart Systems and Artificial Intelligence, Nazarbayev University(纳扎尔巴耶夫大学智能系统与人工智能研究所)
Alzheimer's disease (AD) is a progressive brain disorder that causes memory and functional impairments. The advances in machine learning and publicly available medical datasets initiated multiple studies in AD diagnosis. In this work, we utilize a multi-modal deep learning approach in classifying normal cognition, mild cognitive impairment and AD classes on the basis of structural MRI and diffusion tensor imaging (DTI) scans from the OASIS-3 dataset. In addition to a conventional multi-modal network, we also present an input agnostic architecture that allows diagnosis with either sMRI or DTI s…
On the Utility of Foundation Models for Fast MRI: Vision-Language-Guided Image Reconstruction
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital(麻省总医院Athinoula A. Martinos生物医学成像中心);Harvard Medical School(哈佛医学院);Massachusetts General Hospital(麻省总医院)
Guangdong Cardiovascular Institute(广东省心血管病研究所);Guangdong Provincial People’s Hospital(广东省人民医院);Guangdong Academy of Medical Sciences(广东省医学科学院);University of Notre Dame(圣母大学)
Coronary artery disease (CAD) is the most common cause of death globally, and its diagnosis is usually based on manual myocardial segmentation of Magnetic Resonance Imaging (MRI) sequences. As the manual segmentation is tedious, time-consuming and with low applicability, automatic myocardial segmentation using machine learning techniques has been widely explored recently. However, almost all the existing methods treat the input MRI sequences independently, which fails to capture the temporal information between sequences, e.g., the shape and location information of the myocardium in sequences …
Wellcome Centre for Human Neuroimaging, University College London(伦敦大学学院惠康人类神经影像中心);Institute of Neurology, University College London(伦敦大学学院神经学研究所)
We present a tool for resolution recovery in multimodal clinical magnetic resonance imaging (MRI). Such images exhibit great variability, both biological and instrumental. This variability makes automated processing with neuroimaging analysis software very challenging. This leaves intelligence extractable only from large-scale analyses of clinical data untapped, and impedes the introduction of automated predictive systems in clinical care. The tool presented in this paper enables such processing, via inference in a generative model of thick-sliced, multi-contrast MR scans. All model parameters…
Mohamed Bin Zayed University of Artificial Intelligence(穆罕默德·本·扎耶德人工智能大学)
Glioblastoma is a common brain malignancy that tends to occur in older adults and is almost always lethal. The effectiveness of chemotherapy, being the standard treatment for most cancer types, can be improved if a particular genetic sequence in the tumor known as MGMT promoter is methylated. However, to identify the state of the MGMT promoter, the conventional approach is to perform a biopsy for genetic analysis, which is time and effort consuming. A couple of recent publications proposed a connection between the MGMT promoter state and the MRI scans of the tumor and hence suggested the use o…
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School(哈佛医学院麻省总医院Martinos生物医学影像中心);Massachusetts Institute of Technology(麻省理工学院);Cornell University(康奈尔大学);University College London(伦敦大学学院)
Probabilistic atlas priors have been commonly used to derive adaptive and robust brain MRI segmentation algorithms. Widely-used neuroimage analysis pipelines rely heavily on these techniques, which are often computationally expensive. In contrast, there has been a recent surge of approaches that leverage deep learning to implement segmentation tools that are computationally efficient at test time. However, most of these strategies rely on learning from manually annotated images. These supervised deep learning methods are therefore sensitive to the intensity profiles in the training dataset. To…
Speech Audio Generation from dynamic MRI via a Knowledge Enhanced Conditional Variational Autoencoder
Department of Computer Science, The University of Hong Kong(香港大学计算机科学系);School of Software Engineering, Xi'an Jiaotong University(西安交通大学软件工程学院);Wake Forest University School of Medicine(威克森林大学医学学院);Department of Radiology, Harvard Medical School(哈佛医学院放射科)
GE Global Research Center(GE全球研究中心);Technische Universität München(慕尼黑工业大学);INSERM(法国国家健康与医学研究院);Université de Lorraine(洛林大学);GE Healthcare(GE医疗)
To develop an efficient motion-compensated reconstruction technique for free-breathing cardiac magnetic resonance imaging (MRI) that allows high-quality images to be reconstructed from multiple undersampled single-shot acquisitions. The proposed method is a joint image reconstruction and motion correction method consisting of several steps, including a non-rigid motion extraction and a motion-compensated reconstruction. The reconstruction includes a denoising with the Beltrami regularization, which offers an ideal compromise between feature preservation and staircasing reduction. Results were …
From Explanations to Architecture: Explainability-Driven CNN Refinement for Brain Tumor Classification in MRI
American International Brac University Faculty of Psychology University-Bangladesh(美国国际布拉大学心理学学院(孟加拉国));Shinawatra University Department of Computer Science(辛纳瓦特大学计算机科学系);American International North South University(美国国际北南大学);American International University–Bangladesh Department of Computer Science(美国国际大学–孟加拉国计算机科学系);Multimedia University Department of Computer Science(多媒体大学计算机科学系)
Hybrid Learning: A Novel Combination of Self-Supervised and Supervised Learning for Joint MRI Reconstruction and Denoising in Low-Field MRI
New York University Grossman School of Medicine(纽约大学格罗斯曼医学院);NYU Tandon School of Engineering(纽约大学坦登工程学院);Icahn School of Medicine at Mount Sinai(西奈山伊坎医学院)
Although deep learning (DL) has gained much popularity for accelerated magnetic resonance imaging (MRI), recent studies have shown that DL-based MRI reconstruction models could be oversensitive to tiny input perturbations (that are called 'adversarial perturbations'), which cause unstable, low-quality reconstructed images. This raises the question of how to design robust DL methods for MRI reconstruction. To address this problem, we propose a novel image reconstruction framework, termed SMOOTHED UNROLLING (SMUG), which advances a deep unrolling-based MRI reconstruction model using a randomized…
Columbia University(哥伦比亚大学);Columbia University Irving Medical Center(哥伦比亚大学欧文医学中心);Zuckerman Institute(扎克曼研究所)
Cerebral blood volume (CBV) is a hemodynamic correlate of oxygen metabolism and reflects brain activity and function. High-resolution CBV maps can be generated using the steady-state gadolinium-enhanced MRI technique. Such a technique requires an intravenous injection of exogenous gadolinium based contrast agent (GBCA) and recent studies suggest that the GBCA can accumulate in the brain after frequent use. We hypothesize that endogenous sources of contrast might exist within the most conventional and commonly acquired structural MRI, potentially obviating the need for exogenous contrast. Here,…
Inspired by the first-order method of Malitsky and Pock, we propose a new variational framework for compressed MR image reconstruction which introduces the application of a rotation-invariant discretization of total variation functional into MR imaging while exploiting BM3D frame as a sparsifying transform. In the first step, we provide theoretical and numerical analysis establishing the exceptional rotation-invariance property of this total variation functional and observe its superiority over other well-known variational regularization terms in both upright and rotated imaging setups. Thereu…
Early prediction of pathological complete response (pCR) following neoadjuvant chemotherapy (NAC) for breast cancer plays a critical role in surgical planning and optimizing treatment strategies. Recently, machine and deep-learning based methods were suggested for early pCR prediction from multi-parametric MRI (mp-MRI) data including dynamic contrast-enhanced MRI and diffusion-weighted MRI (DWI) with moderate success. We introduce PD-DWI, a physiologically decomposed DWI machine-learning model to predict pCR from DWI and clinical data. Our model first decomposes the raw DWI data into the vario…
The human cortical layer exhibits a convoluted morphology that is unique to each individual. Conventional volumetric fMRI processing schemes take for granted the rich information provided by the underlying anatomy. We present a method to study fMRI data on subject-specific cerebral hemisphere cortex (CHC) graphs, which encode the cortical morphology at the resolution of voxels in 3-D. We study graph spectral energy metrics associated to fMRI data of 100 subjects from the Human Connectome Project database, across seven tasks. Experimental results signify the strength of CHC graphs' Laplacian ei…