C.脑红蛋白对感觉信息处理的调节elegans
Modulation of sensory information processing by a neuroglobin in C. elegans
摘要：
感觉受体神经元将其动态范围与生态相关的刺激强度相匹配。在大多数受体中，这种调谐是如何实现的，人们知之甚少。我们在C.两种假定的分子O2传感器，一种脑红蛋白和O2-结合可溶性鸟苷酸环化酶，对抗性地工作，以塑造一个缓慢的S形O2响应曲线，当O2达到21%时，该曲线被调整为接近饱和。glb-5通过在O2水平下降时抑制URX中O2诱发的Ca 2+反应来施加这种S形功能。在没有GLB-5的情况下，URX响应曲线在15%O2下接近饱和。在行为上，GLB-5信号通路扩大了C. elegans同时保持对21%O2的强烈回避。我们的计算趋氧性模型表明，GLB-5调制URX反应和逆转行为之间的关系是足以扩大O2偏好。因此，脑红蛋白可以改变神经信息编码，导致感知和行为改变。
英文摘要：
Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. We show that in the C. elegans URX O2 sensing neurons two putative molecular O2 sensors, a neuroglobin and O2-binding soluble guanylate cyclases, work antagonistically to sculpt a slowly sigmoidal O2 response curve tuned to approach saturation when O2 reaches 21%. glb-5 imposes this sigmoidal function by inhibiting O2-evoked Ca2+ responses in URX when O2 levels fall. Without GLB-5, the URX response curve approaches saturation at 15% O2. Behaviorally, GLB-5 signaling broadens the O2 preference of C. elegans while maintaining strong avoidance of 21% O2. Our computational aerotaxis model suggests that the relationship between GLB-5-modulated URX responses and reversal behavior is sufficient to broaden O2-preference. Thus, a neuroglobin can shift neural information coding leading to a change in perception and altered behavior.
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