结构已知，功能未知：一门基于探究的本科生生物化学实验课程
Known Structure, Unknown Function: An Inquiry-based Undergraduate Biochemistry Laboratory Course
摘要：
本科生生物化学实验室课程往往不为学生提供一个真实的研究经验，特别是当实验室的明确目的是纯粹的教学。然而，一个教学实验室课程，是调查和研究为基础，可以同时传授科学知识，培养学生的研究专长和信心。我们已经开发了一个为期一年的本科生生物化学实验室课程，学生通过实验和计算确定已知三维结构的蛋白质的功能。课程的前半部分是基于探究和模块化设计;学生学习一般的生物化学技术，同时为第二学期的研究实验做准备。在第一学期学习了标准的生物化学方法后，学生在第二学期独立地追求自己的（原始）研究项目。这一新的课程已经产生了学生的表现和信心的各种指标评估的改善。为了向学生和教师传播教学资源，可在http://biochemlab.org上免费访问生物化学实验室教育资源。
英文摘要：
Undergraduate biochemistry laboratory courses often do not provide students with an authentic research experience, particularly when the express purpose of the laboratory is purely instructional. However, an instructional laboratory course that is inquiry- and research-based could simultaneously impart scientific knowledge and foster a student's research expertise and confidence. We have developed a year-long undergraduate biochemistry laboratory curriculum wherein students determine, via experiment and computation, the function of a protein of known three-dimensional structure. The first half of the course is inquiry-based and modular in design; students learn general biochemical techniques while gaining preparation for research experiments in the second semester. Having learned standard biochemical methods in the first semester, students independently pursue their own (original) research projects in the second semester. This new curriculum has yielded an improvement in student performance and confidence as assessed by various metrics. To disseminate teaching resources to students and instructors alike, a freely accessible Biochemistry Laboratory Education resource is available at http://biochemlab.org.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
