We present a single, unified, multi-scale model to study the attachment\detachment dynamics of two deforming, near spherical cells, coated with binding ligands and subject to a slow, homogeneous shear flow in a viscous fluid medium. The binding ligands on the surface of the cells experience attractive and repulsive forces in an ionic medium and exhibit finite resistance to rotation via bond tilting. The macroscale drag forces and couples describing the fluid flow inside the small separation gap between the cells, are calculated using a combination of methods in lubrication theory and previously published numerical results. For a select range of material and fluid parameters, a hysteretic transition of the sticking probability curves between the adhesion and fragmentation domain is attributed to a nonlinear relation between the total microscale binding forces and the separation gap between the cells. We show that adhesion is favored in highly ionic fluids, increased deformability of the cells, elastic binders and a higher fluid shear rate (until a critical value). Continuation of the limit points predict a bistable region, indicating an abrupt switching between the adhesion and fragmentation regimes at critical shear rates, and suggesting that adhesion of two deformable surfaces in shearing fluids may play a significant dynamical role in some cell adhesion applications.
Numerical analysis of a mechanotransduction dynamical model reveals homoclinic bifurcations of extracellular matrix mediated oscillations of the mesenchymal stem cell fate
National Technical University of Athens（雅典国立技术大学）；Università degli Studi di Napoli Federico II（那不勒斯费德里科二世大学）
Epithelial-substrate coupling strength regulates the landscape of the traction in cohesive monolayers: a parametric study and a revisit to "size effect"
Irregular curvature at focal adhesions modulates Piezo1 activity and low frequency ultrasound induced apoptosis in cancer cells
University of Belgrade（贝尔格莱德大学）；Victor Chang Cardiac Research Institute（维克多·陈心脏研究所）；University of New South Wales（新南威尔士大学）；Lancaster University（兰卡斯特大学）
Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses
