移动配体之间的空间相互作用促进被动内吞作用中的完全包裹
Steric interactions between mobile ligands facilitate complete wrapping in passive endocytosis
摘要：
受体介导的内吞作用是一种普遍存在的过程，通过该过程，细胞内化生物或合成的纳米级物体，包括病毒、单细胞寄生虫和用于药物或基因递送的纳米医学载体。在被动内吞作用中，细胞质膜包裹由配体-受体复合驱动的“入侵者”颗粒。通过理论和数值模拟，在这里，我们展示了如何装饰的自由扩散和非相互作用（理想）配体的粒子是显着更难以包装比那些配体是固定的或相互作用的空间。我们的模型合理化的摄取机制和入侵者的结构细节，如配体的大小，流动性和配体/受体亲和力之间的关系，提供了一个全面的图片病原体的内吞作用，并帮助合理设计有效的药物输送载体。
英文摘要：
Receptor-mediated endocytosis is an ubiquitous process through which cells internalize biological or synthetic nanoscale objects, including viruses, unicellular parasites, and nanomedical vectors for drug or gene delivery. In passive endocytosis the cell plasma membrane wraps around the "invader" particle driven by ligand-receptor complexation. By means of theory and numerical simulations, here we demonstrate how particles decorated by freely diffusing and non-mutually-interacting (ideal) ligands are significantly more difficult to wrap than those where ligands are either immobile or interact sterically with each other. Our model rationalizes the relationship between uptake mechanism and structural details of the invader, such as ligand size, mobility and ligand/receptor affinity, providing a comprehensive picture of pathogen endocytosis and helping the rational design of efficient drug delivery vectors.
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