剪切流中细胞粘附的动力学状态：从滑动到滚动
Dynamic states of cells adhering in shear flow: from slipping to rolling
摘要：
受白细胞在血管系统中滚动粘附的启发，我们研究了细胞如何在壁上方的线性剪切流中移动，它们可以通过特定的受体-配体键粘附到壁上。我们的计算机模拟是基于朗之万方程占流体动力学相互作用，热波动和粘合剂的相互作用。与早期的方法相比，我们的模型不仅包括随机规则的形成和断裂的债券，但也完全解决了受体和配体的位置。我们确定了五个不同的动态运动状态方面的平移和角速度的细胞。不同状态之间的转换映射出的动态状态图作为键形成和断裂的速率的函数。例如，当细胞在键的作用下开始粘附时，其平移速度和角速度变得同步，并且动态状态从滑动变为滚动。我们还研究了非分子参数的影响。特别是，我们发现，介质粘度的增加导致稳定滚动区域的特征扩张，以牺牲牢固粘附区域为代价，但不以牺牲自由或瞬态运动区域为代价。我们的结果可用于逆方法，根据滚动粘附的流动室数据确定单键参数。
英文摘要：
Motivated by rolling adhesion of white blood cells in the vasculature, we study how cells move in linear shear flow above a wall to which they can adhere via specific receptor-ligand bonds. Our computer simulations are based on a Langevin equation accounting for hydrodynamic interactions, thermal fluctuations and adhesive interactions. In contrast to earlier approaches, our model not only includes stochastic rules for the formation and rupture of bonds, but also fully resolves both receptor and ligand positions. We identify five different dynamic states of motion in regard to the translational and angular velocities of the cell. The transitions between the different states are mapped out in a dynamic state diagram as a function of the rates for bond formation and rupture. For example, as the cell starts to adhere under the action of bonds, its translational and angular velocities become synchronized and the dynamic state changes from slipping to rolling. We also investigate the effect of non-molecular parameters. In particular, we find that an increase in viscosity of the medium leads to a characteristic expansion of the region of stable rolling to the expense of the region of firm adhesion, but not to the expense of the regions of free or transient motion. Our results can be used in an inverse approach to determine single bond parameters from flow chamber data on rolling adhesion.
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