We present a theoretical model for the description of the adsorption kinetics of globular proteins onto charged core-shell microgel particles based on Dynamic Density Functional Theory (DDFT). This model builds on a previous description of protein adsorption thermodynamics [Yigit \textit{et al}, Langmuir 28 (2012)], shown to well interpret the available calorimetric experimental data of binding isotherms. In practice, a spatially-dependent free-energy functional including the same physical interactions is built, and used to study the kinetics via a generalised diffusion equation. To test this model, we apply it to the case study of Lysozyme adsorption on PNIPAM coated nanoparticles, and show that the dynamics obtained within DDFT is consistent with that extrapolated from experiments. We also perform a systematic study of the effect of various parameters in our model, and investigate the loading dynamics as a function of proteins' valence and hydrophobic adsorption energy, as well as their concentration and that of the nanoparticles. Although we concentrated here on the case of adsorption for a single protein type, the model's generality allows to study multi-component system, providing a reliable instrument for future studies of competitive and cooperative adsorption effects often encountered in protein adsorption experiments.
Application in the Ethanol Fermentation of Immobilized Yeast Cells in Matrix of Alginate/Magnetic Nanoparticles, on Chitosan-Magnetite Microparticles and Cellulose-coated Magnetic Nanoparticles
Sulfobetaine-Phosphonate Block Copolymer Coated Iron Oxide Nanoparticles for Genomic Locus Targeting and Magnetic Micromanipulation in the Nucleus of Living Cells
Near-infrared photothermal response of plasmonic gold-coated nanoparticles in tissues
我们提出了一种新的方法来了解金-硅核-壳纳米粒子注射到鸡组织在近红外激光照射下的时间依赖性升温过程。金纳米壳强烈吸收近红外辐射，并有效地将吸收的能量转化为热量。实验结果与基于生物传热的数值计算结果吻合较好。我们的工作改进了最近一项研究的分析[Richardson等人，Nano Lett. 9，1139（2009）]通过包括培养基灌注对温度升高的影响。理论分析也可用于估计纳米粒子在实验样品中的分布，并为新系统的温度分布提供相对准确的预测。这种方法将提供一种新颖的和可靠的工具，加快光热研究和设计国家的最先进的光热设备。
Copper phosphate micro-flowers coated with indocyanine green and iron oxide nanoparticles for in vivo localization optoacoustic tomography and magnetic actuation
Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles does not affect kidney function but causes acute effect on the cardiovascular function in healthy mice
本研究描述了静脉注射聚丙烯酸（PAA）涂层γ-Fe 2 O3纳米粒（10 mg kg-1）在健康BALB/cJ小鼠器官、细胞和亚细胞水平的分布，并平行讨论了纳米粒注射对肾功能、血压和血管收缩力的影响。磁共振成像（MRI）和透射电子显微镜（TEM）显示，静脉输注后1小时内，NPs在肝脏中蓄积，通过内皮细胞和枯否细胞的细胞内摄取调节，随后在肾细胞，特别是近端小管的细胞质，足细胞和系膜细胞中的细胞内摄取调节。通过动脉酸碱状态和长期留置导管后测量肾小球滤过率（GFR）来评价NP对肾功能的影响。注射生理盐水或NP后0.5 h，小鼠动脉pH值分别为7.46和7.41，在接下来的12 h内没有变化。此外，注射NP也不影响动脉PCO 2或[HCO 3-]。NP注射后24小时和96小时，GFR平均值分别为11.0和13.0 ml min-1 g-1，与对照组（14.0和14.0 ml min-1 g-1）具有统计学可比性。NP注射后12- 24小时平均动脉血压（MAP）降低（111 vs 123 min-1），与肠系膜小动脉收缩力降低相关，通过肌造影显示肠系膜小动脉收缩力降低，从而降低内皮功能。总之，我们的研究表明，超顺磁性氧化铁纳米颗粒的积累不会影响健康小鼠的肾功能，但会暂时降低血压。
Orientation-Dependent Protein Binding at Nanoparticle Interfaces
University College Dublin（都柏林大学学院）；School of Physics, University College Dublin（都柏林大学学院物理学院）；Institute for Discovery, University College Dublin（都柏林大学学院发现研究所）
Efficacy of 3D-Printed chitosan-cerium oxide dressings coated with vancomycin-loaded alginate for chronic wounds management
K. N. Toosi University of Technology（开姆纳·托基大学）；Royan Institute（罗扬研究所）；Royan Institute for Stem Cell Biology and Technology, ACECR（罗扬干细胞生物学与技术研究所，ACECR）；Marquette University School of Dentistry（马凯特大学牙学院）；Batten College of Engineering and Technology, Old Dominion University（老道明大学巴滕工程学院与技术学院）
