用二氧化硅包覆的氧化锰纳米颗粒热疗HeLa细胞
Hyperthermia HeLa cell treatment with silica coated manganese oxide nanoparticles
摘要：
研究了高频交变磁场对与锰氧化物钙钛矿La0.56（SrCa）0.22MnO3铁磁纳米颗粒孵育的HeLa肿瘤细胞的影响。对颗粒进行尺寸选择过程，并涂覆二氧化硅以改善其生物相容性。用HeLa肿瘤细胞进行的对照试验表明，细胞存活和生长速率不受细胞中颗粒内化的影响，也不受没有纳米颗粒的细胞上的电磁场的影响。然而，将交变电磁场应用于与该二氧化硅涂覆的氧化锰一起孵育的细胞诱导了显著的细胞损伤，最终通过凋亡机制导致细胞死亡。即使在高温处理期间细胞培养物中的温度升高低于0.5 ℃，也会触发细胞死亡。
英文摘要：
The effect of a high frequency alternating magnetic field on HeLa tumour cells incubated with ferromagnetic nanoparticles of manganese oxide perovskite La0.56(SrCa)0.22MnO3 have been studied. The particles were subjected to a size selection process and coated with silica to improve their biocompatibility. The control assays made with HeLa tumour cells showed that cell survival and growth rate were not affected by the particle internalization in cells, or by the electromagnetic field on cells without nanoparticles. However, the application of an alternating electromagnetic field to cells incubated with this silica coated manganese oxide induced a significant cellular damage that finally lead to cell death by an apoptotic mechanism. Cell death is triggered even thought the temperature increase in the cell culture during the hyperthermia treatment is lower than 0.5 C.
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