arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 1108.0200physics.optics
收藏

细菌视紫红质:可调谐的光学非线性磁响应

Bacteriorhodopsin: Tunable Optical Nonlinear Magnetic Response

F. A. Bovino, M. C. Larciprete, C. Sibilia, M. Giardina, G. Váró, C. Gergely

摘要:

我们报告了一个强大的和可调的磁光非线性响应的细菌视紫红质(BR)下的“非共振”飞秒(fs)脉冲激发,通过检测的偏振图的非共线的二次谐波信号的定向BR膜,作为输入光束功率的函数。BR是一种光驱动的质子泵,具有独特的光化学作用,由嵌入蛋白质中的全反式视网膜发色团引发。最近在光遗传学的新领域中发现了这种光子分子机器的一个优雅应用,其中脑细胞中BR的遗传表达赋予细胞光响应性,从而能够特异性刺激神经元。观察到的BR的强可调磁非线性响应可能会引发在配对光遗传学和功能性磁共振成像的新兴领域中的有前途的应用,从而提供前所未有的神经回路的完整功能映射。

英文摘要:

We report on a strong and tunable magnetic optical nonlinear response of Bacteriorhodopsin (BR) under "off resonance" femtosecond (fs) pulse excitation, by detecting the polarization map of the noncollinear second harmonic signal of an oriented BR film, as a function of the input beam power. BR is a light-driven proton pump with a unique photochemistry initiated by the all trans retinal chromophore embedded in the protein. An elegant application of this photonic molecular machine has been recently found in the new area of optogenetics, where genetic expression of BR in brain cells conferred a light responsivity to the cells enabling thus specific stimulation of neurons. The observed strong tunable magnetic nonlinear response of BR might trigger promising applications in the emerging area of pairing optogenetics and functional magnetic resonance imaging susceptible to provide an unprecedented complete functional mapping of neural circuits.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑