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arXiv 1107.0097cond-mat.stat-mechcond-mat.softphysics.bio-ph
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具有长程相关噪声的DNA的力诱导解压缩

Force Induced Unzipping of DNA with Long Range Correlated Noise

Pui-Man Lam, Yi Zhen

摘要:

在双链DNA在外力作用下解链的模型中,推导并求解了自由能稳态分布的Fokker-Planck方程。随机DNA序列的自相关函数可以是一般形式,包括长程相关。在奥尔斯坦-乌伦贝克噪声的情况下,其特征在于有限的相关长度,我们的结果简化为Allahverdyan等人的精确结果,在白噪声极限下,解压缩碱基对的平均数量为<X>~1/f^2,其中f是与临界力的偏差。在长距离相关噪声的情况下,其中集成的自相关是发散的,我们发现<X>在f=0时是有限的,其值随着相关性变得更长范围而减小。这表明,长距离相关性实际上稳定了DNA序列,防止解压缩。我们的结果也与Allahverdyan等人的研究结果一致,使用数值生成的长程相关噪声。

英文摘要:

We derive and solve a Fokker-Planck equation for the stationary distribution of the free energy, in a model of unzipping of double-stranded DNA under external force. The autocorrelation function of the random DNA sequence can be a general form, including long range correlations. In the case of Orstein-Uhlenbeck noise, characterized by a finite correlation length, our result reduces to the exact result of Allahverdyan et al, with the average number of unzipped base pairs going as <X>~1/f^2 in the white noise limit, where f is the deviation from the critical force. In the case of long range correlated noise, where the integrated autocorrelation is divergent, we find that <X> is finite at f=0, with its value decreasing as the correlations become longer range. This shows that long range correlations actually stabilize the DNA sequence against unzipping. Our result is also in agreement with the findings of Allahverdyan et al, obtained using numerical generation of the long range correlated noise.

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