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arXiv 1106.0863q-bio.NC
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A电流和I型/II型转换决定公共输入的集体尖峰

The A-current and Type I / Type II transition determine collective spiking from common input

Andrea K. Barreiro, Evan L. Thilo, Eric Shea-Brown

摘要:

在整个神经系统中,对神经元对和神经元组之间的相关或同步放电的机制和影响正在进行深入的研究。一个普遍存在的电路特征可以引起这种相关性,它包括对细胞对和细胞群的重叠或共同输入,导致共同的脉冲序列响应。在这里,我们使用计算工具来研究如何通过受体细胞的生理学来调节共同输入电流到共同尖峰输出的转移。我们专注于一个关键的电导- gA,为A型钾电流-驱动神经元之间的“II型”兴奋性(低gA),和“I型”兴奋性(高gA)。不管gA如何,细胞将共同的输入波动转化为几乎同时发放尖峰的趋势。然而,这个过程是更明显的低gA值,如先前预测的减少“相”模型。因此,对于给定水平的共同输入,II型神经元产生在短时间尺度上相对更相关的尖峰。随着时间的推移,这种趋势发生逆转,II型神经元产生的相关性相对较低的脉冲序列。这是因为这些细胞的增加趋势,同时尖峰是平衡的相反趋势,在更大的时间滞后。我们证明了一个新的神经信号处理的含义:具有长时间常数的下游细胞选择性地驱动I型细胞群体上游,和II型细胞群体的时间常数短。我们的研究结果是通过高通量的数值模拟建立的,并通过细胞的过滤特性和非线性动力学解释。

英文摘要:

The mechanisms and impact of correlated, or synchronous, firing among pairs and groups of neurons is under intense investigation throughout the nervous system. A ubiquitous circuit feature that can give rise to such correlations consists of overlapping, or common, inputs to pairs and populations of cells, leading to common spike train responses. Here, we use computational tools to study how the transfer of common input currents into common spike outputs is modulated by the physiology of the recipient cells. We focus on a key conductance - gA, for the A-type potassium current - which drives neurons between "Type II" excitability (low gA), and "Type I" excitability (high gA). Regardless of gA, cells transform common input fluctuations into a ten- dency to spike nearly simultaneously. However, this process is more pronounced at low gA values, as previously predicted by reduced "phase" models. Thus, for a given level of common input, Type II neurons produce spikes that are relatively more correlated over short time scales. Over long time scales, the trend reverses, with Type II neurons producing relatively less correlated spike trains. This is because these cells' increased tendency for simultaneous spiking is balanced by opposing tendencies at larger time lags. We demonstrate a novel implication for neural signal processing: downstream cells with long time constants are selectively driven by Type I cell populations upstream, and those with short time constants by Type II cell populations. Our results are established via high-throughput numerical simulations, and explained via the cells' filtering properties and nonlinear dynamics.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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