We propose and develop a novel and effective perfect sampling methodology for simulating from posteriors corresponding to mixtures with either known (fixed) or unknown number of components. For the latter we consider the Dirichlet process-based mixture model developed by these authors, and show that our ideas are applicable to conjugate, and importantly, to non-conjugate cases. As to be expected, and, as we show, perfect sampling for mixtures with known number of components can be achieved with much less effort with a simplified version of our general methodology, whether or not conjugate or non-conjugate priors are used. While no special assumption is necessary in the conjugate set-up for our theory to work, we require the assumption of bounded parameter space in the non-conjugate set-up. However, we argue, with appropriate analytical, simulation, and real data studies as support, that such boundedness assumption is not unrealistic and is not an impediment in practice. Not only do we validate our ideas theoretically and with simulation studies, but we also consider application of our proposal to three real data sets used by several authors in the past in connection with mixture models. The results we achieved in each of our experiments with either simulation study or real data application, are quite encouraging.
We consider the question of Markov chain Monte Carlo sampling from a general stick-breaking Dirichlet process mixture model, with concentration parameter alpha. This paper introduces a Gibbs sampling algorithm that combines the slice sampling approach of Walker (2007) and the retrospective sampling approach of Papaspiliopoulos and Roberts (2008). Our general algorithm is implemented as efficient open source C++ software, available as an R package, and is based on a blocking strategy similar to that suggested by Papaspiliopoulos (2008) and implemented by Yau et al (2011). We discuss the difficu…
Recent work on overfitting Bayesian mixtures of distributions offers a powerful framework for clustering multivariate data using a latent Gaussian model which resembles the factor analysis model. The flexibility provided by overfitting mixture models yields a simple and efficient way in order to estimate the unknown number of clusters and model parameters by Markov chain Monte Carlo (MCMC) sampling. The present study extends this approach by considering a set of eight parameterizations, giving rise to parsimonious representations of the covariance matrix per cluster. A Gibbs sampler combined w…
This paper provides a framework for estimating the mean and variance of a high-dimensional normal density. The main setting considered is a fixed number of vector following a high-dimensional normal distribution with unknown mean and diagonal covariance matrix. The diagonal covariance matrix can be known or unknown. If the covariance matrix is unknown, the sample size can be as small as $2$. The proposed estimator is based on the idea that the unobserved pairs of mean and variance for each dimension are drawn from an unknown bivariate distribution, which we model as a mixture of normal-inverse…
In many real-world scenarios, such as gene knockout experiments, targeted interventions are often accompanied by unknown interventions at off-target sites. Moreover, different units can get randomly exposed to different unknown interventions, thereby creating a mixture of interventions. Identifying different components of this mixture can be very valuable in some applications. Motivated by such situations, in this work, we study the problem of identifying all components present in a mixture of interventions on a given causal Bayesian Network. We construct an example to show that, in general, t…
Financial studies require volatility based models which provides useful insights on risks related to investments. Stochastic volatility models are one of the most popular approaches to model volatility in such studies. The asset returns under study may come in multiple clusters which are not captured well assuming standard distributions. Mixture distributions are more appropriate in such situations. In this work, an algorithm is demonstrated which is capable of studying finite mixtures but with unknown number of components. This algorithm uses a Birth-Death process to adjust the number of comp…
Estimation of finite mixture models when the mixing distribution support is unknown is an important problem. This paper gives a new approach based on a marginal likelihood for the unknown support. Motivated by a Bayesian Dirichlet prior model, a computationally efficient stochastic approximation version of the marginal likelihood is proposed and large-sample theory is presented. By restricting the support to a finite grid, a simulated annealing method is employed to maximize the marginal likelihood and estimate the support. Real and simulated data examples show that this novel stochastic appro…
Recent advances on overfitting Bayesian mixture models provide a solid and straightforward approach for inferring the underlying number of clusters and model parameters in heterogeneous datasets. The applicability of such a framework in clustering correlated high dimensional data is demonstrated. For this purpose an overfitting mixture of factor analyzers is introduced, assuming that the number of factors is fixed. A Markov chain Monte Carlo (MCMC) sampler combined with a prior parallel tempering scheme is used to estimate the posterior distribution of model parameters. The optimal number of f…
This paper proposes solutions to three issues pertaining to the estimation of finite mixture models with an unknown number of components: the non-identifiability induced by overfitting the number of components, the mixing limitations of standard Markov Chain Monte Carlo (MCMC) sampling techniques, and the related label switching problem. An overfitting approach is used to estimate the number of components in a finite mixture model via a Zmix algorithm. Zmix provides a bridge between multidimensional samplers and test based estimation methods, whereby priors are chosen to encourage extra groups…
Gaussian Mixture Model with unknown diagonal covariances via continuous sparse regularization
Centrale Lyon, CNRS UMR 5208, Institut Camille Jordan（里昂中央理工学院，法国国家科学研究中心联合研究实验室5208，卡米尔·乔丹研究所）；Institut Universitaire de France (IUF)（法兰西学院）；Univ. Claude Bernard, CNRS UMR 5208, Institut Camille Jordan（克洛德·贝尔纳大学，法国国家科学研究中心联合研究实验室5208，卡米尔·乔丹研究所）
The entropy is a measure of uncertainty that plays a central role in information theory. When the distribution of the data is unknown, an estimate of the entropy needs be obtained from the data sample itself. We propose a semi-parametric estimate, based on a mixture model approximation of the distribution of interest. The estimate can rely on any type of mixture, but we focus on Gaussian mixture model to demonstrate its accuracy and versatility. Performance of the proposed approach is assessed through a series of simulation studies. We also illustrate its use on two real-life data examples.
Riemannian Gradient Descent for Gaussian Mixture Models with unknown diagonal covariances
Centrale Lyon, INSA Lyon, Université Lyon 1, Université Jean Monnet, CNRS, ICJ UMR5208（里昂中央理工学院、里昂国立应用科学学院、里昂第一大学、让·莫内大学、法国国家科学研究中心、ICJ UMR5208）；Institut Universitaire de France (IUF)（法兰西学院）
We consider a semiparametric mixture of two univariate density functions where one of them is known while the weight and the other function are unknown. Such mixtures have a history of application to the problem of detecting differentially expressed genes under two or more conditions in microarray data. Until now, some additional knowledge about the unknown component (e.g. the fact that it belongs to a location family) has been assumed. As opposed to this approach, we do not assume any additional structure on the unknown density function. For this mixture model, we derive a new sufficient iden…
We propose a structure of a semiparametric two-component mixture model when one component is parametric and the other is defined through L-moments conditions. Estimation of a two-component mixture model with an unknown component is very difficult when no particular assumption is made on the structure of the unknown component. A previous work was proposed to incorporate a prior linear information concerning the distribution function of the unknown component such as moment constraints. We propose here to incorporate a prior linear information about the quantile function of the unknown component …
We exploit a suitable moment-based characterization of the mixture of Poisson distribution for developing Bayesian inference for the unknown size of a finite population whose units are subject to multiple occurrences during an enumeration sampling stage. This is a particularly challenging setting for which many other attempts have been made for inferring the unknown characteristics of the population. Here we put particular emphasis on the construction of a default prior elicitation of the characteristics of the mixing distribution. We assess the comparative performance of our approach in real …
We propose a structure of a semiparametric two-component mixture model when one component is parametric and the other is defined through linear constraints on its distribution function. Estimation of a two-component mixture model with an unknown component is very difficult when no particular assumption is made on the structure of the unknown component. A symmetry assumption was used in the literature to simplify the estimation. Such method has the advantage of producing consistent and asymptotically normal estimators, and identifiability of the semiparametric mixture model becomes tractable. S…
Scalable Dirichlet Process Mixture Models with Unknown Concentration and Adaptive Covariance for High-Dimensional Clustering Applied to Leukemia Transcriptomics
Los Alamos National Laboratory（洛斯阿拉莫斯国家实验室）；University of New Mexico Comprehensive Cancer Center（新墨西哥大学综合癌症中心）
Factor analysis is broadly used as a powerful unsupervised machine learning tool for reconstruction of hidden features in recorded mixtures of signals. In the case of a linear approximation, the mixtures can be decomposed by a variety of model-free Blind Source Separation (BSS) algorithms. Most of the available BSS algorithms consider an instantaneous mixing of signals, while the case when the mixtures are linear combinations of signals with delays is less explored. Especially difficult is the case when the number of sources of the signals with delays is unknown and has to be determined from t…
We consider the simulation of distributions that are a mixture of discrete and continuous components. We extend a Metropolis-Hastings-based perfect sampling algorithm of Corcoran and Tweedie to allow for a broader class of transition candidate densities. The resulting algorithm, know as a "class coupler", is fast to implement and is applicable to purely discrete or purely continuous densities as well. Our work is motivated by the study of a composite hypothesis test in a Bayesian setting via posterior simulation and we give simulation results for some problems in this area.
We study full Bayesian procedures for sparse linear regression when errors have a symmetric but otherwise unknown distribution. The unknown error distribution is endowed with a symmetrized Dirichlet process mixture of Gaussians. For the prior on regression coefficients, a mixture of point masses at zero and continuous distributions is considered. We study behavior of the posterior with diverging number of predictors. Conditions are provided for consistency in the mean Hellinger distance. The compatibility and restricted eigenvalue conditions yield the minimax convergence rate of the regression…
Unsupervised mixture learning (UML) aims at identifying linearly or nonlinearly mixed latent components in a blind manner. UML is known to be challenging: Even learning linear mixtures requires highly nontrivial analytical tools, e.g., independent component analysis or nonnegative matrix factorization. In this work, the post-nonlinear (PNL) mixture model -- where unknown element-wise nonlinear functions are imposed onto a linear mixture -- is revisited. The PNL model is widely employed in different fields ranging from brain signal classification, speech separation, remote sensing, to causal di…
Pamminger and Fruwirth-Schnatter (2010) considered a Bayesian approach to model-based clustering of categorical time series assuming a fixed number of clusters. But the popular methods for selecting the number of clusters, for example, the Bayes Information Criterion (BIC), turned out to have severe problems in the categorical time series context. In this paper, we circumvent the difficulties of choosing the number of clusters by adopting the Bayesian semiparametric mixture model approach introduced by Bhattacharya (2008), who assume that the number of clusters is a random quantity, but is bou…
Prognostics of Multisensor Systems with Unknown and Unlabeled Failure Modes via Bayesian Nonparametric Process Mixtures
Department of Industrial and Systems Engineering, University of Florida（工业与系统工程系，佛罗里达大学）；School of Forest, Fisheries, and Geomatics Sciences, University of Florida（森林、渔业与地理科学学院，佛罗里达大学）
The study of mixture models constitutes a large domain of research in statistics. In the first part of this work, we present phi-divergences and the existing methods which produce robust estimators. We are more particularly interested in the so-called dual formula of phi-divergences. We build a new robust estimator based on this formula. We study its asymptotic properties and give a numerical comparison with existing methods on simulated data. We also introduce a proximal-point algorithm whose aim is to calculate divergence-based estimators. We give some of the convergence properties of this a…
Given a random sample of observations, mixtures of normal densities are often used to estimate the unknown continuous distribution from which the data come. Here we propose the use of this semiparametric framework for testing symmetry about an unknown value. More precisely, we show how the null hypothesis of symmetry may be formulated in terms of normal mixture model, with weights about the centre of symmetry constrained to be equal one another. The resulting model is nested in a more general unconstrained one, with same number of mixture components and free weights. Therefore, after having ma…
DNA is now routinely used in criminal investigations and court cases, although DNA samples taken at crime scenes are of varying quality and therefore present challenging problems for their interpretation. We present a statistical model for the quantitative peak information obtained from an electropherogram (EPG) of a forensic DNA sample and illustrate its potential use for the analysis of criminal cases. In contrast to most previously used methods, we directly model the peak height information and incorporates important artefacts associated with the production of the EPG. Our model has a numbe…
An often-cited fact regarding mixing or mixture distributions is that their density functions are able to approximate the density function of any unknown distribution to arbitrary degrees of accuracy, provided that the mixing or mixture distribution is sufficiently complex. This fact is often not made concrete. We investigate and review theorems that provide approximation bounds for mixing distributions. Connections between the approximation bounds of mixing distributions and estimation bounds for the maximum likelihood estimator of finite mixtures of location- scale distributions are reviewed…
The study of fingerprint individuality aims to determine to what extent a fingerprint uniquely identifies an individual. Recent court cases have highlighted the need for measures of fingerprint individuality when a person is identified based on fingerprint evidence. The main challenge in studies of fingerprint individuality is to adequately capture the variability of fingerprint features in a population. In this paper hierarchical mixture models are introduced to infer the extent of individualization. Hierarchical mixtures utilize complementary aspects of mixtures at different levels of the hi…
This paper uses Gaussian mixture model instead of linear Gaussian model to fit the distribution of every node in Bayesian network. We will explain why and how we use Gaussian mixture models in Bayesian network. Meanwhile we propose a new method, called double iteration algorithm, to optimize the mixture model, the double iteration algorithm combines the expectation maximization algorithm and gradient descent algorithm, and it performs perfectly on the Bayesian network with mixture models. In experiments we test the Gaussian mixture model and the optimization algorithm on different graphs which…
We study posterior contraction behaviors for parameters of interest in the context of Bayesian mixture modeling, where the number of mixing components is unknown while the model itself may or may not be correctly specified. Two representative types of prior specification will be considered: one requires explicitly a prior distribution on the number of mixture components, while the other places a nonparametric prior on the space of mixing distributions. The former is shown to yield an optimal rate of posterior contraction on the model parameters under minimal conditions, while the latter can be…
This paper develops a test for homogeneity in finite mixture models where the mixing proportions are known a priori (taken to be 0.5) and a common nuisance parameter is present. Statistical tests based on the notion of Projected Likelihood Contrasts (PLC) are considered. The PLC is a slight modification of the usual likelihood ratio statistic or the Wilk's $Λ$ and is similar in spirit to the Rao's score test. Theoretical investigations have been carried out to understand the large sample statistical properties of these tests. Simulation studies have been carried out to understand the behavior …
Phylogenetic mixture models are statistical models of character evolution allowing for heterogeneity. Each of the classes in some unknown partition of the characters may evolve by different processes, or even along different trees. The fundamental question of whether parameters of such a model are identifiable is difficult to address, due to the complexity of the parameterization. We analyze mixture models on large trees, with many mixture components, showing that both numerical and tree parameters are indeed identifiable in these models when all trees are the same. We also explore the extent …
This paper is concerned with an important issue in finite mixture modelling, the selection of the number of mixing components. We propose a new penalized likelihood method for model selection of finite multivariate Gaussian mixture models. The proposed method is shown to be statistically consistent in determining of the number of components. A modified EM algorithm is developed to simultaneously select the number of components and to estimate the mixing weights, i.e. the mixing probabilities, and unknown parameters of Gaussian distributions. Simulations and a real data analysis are presented t…
Robust estimation under multivariate normal (MVN) mixture model is always a computational challenge. A recently proposed maximum pseudo \b{eta}-likelihood estimator aims to estimate the unknown parameters of a MVN mixture model in the spirit of minimum density power divergence (DPD) methodology but with a relatively simpler and tractable computational algorithm even for larger dimensions. In this letter, we will rigorously derive the existence and weak consistency of the maximum pseudo \b{eta}-likelihood estimator in case of MVN mixture models under a reasonable set of assumptions.
The max-stable process is an asymptotically justified model for spatial extremes. In particular, we focus on the hierarchical extreme-value process (HEVP), which is a particular max-stable process that is conducive to Bayesian computing. The HEVP and all max-stable process models are parametric and impose strong assumptions including that all marginal distributions belong to the generalized extreme value family and that nearby sites are asymptotically dependent. We generalize the HEVP by relaxing these assumptions to provide a wider class of marginal distributions via a Dirichlet process prior…
Nonparametric mixture models based on the Dirichlet process are an elegant alternative to finite models when the number of underlying components is unknown, but inference in such models can be slow. Existing attempts to parallelize inference in such models have relied on introducing approximations, which can lead to inaccuracies in the posterior estimate. In this paper, we describe auxiliary variable representations for the Dirichlet process and the hierarchical Dirichlet process that allow us to sample from the true posterior in a distributed manner. We show that our approach allows scalable …
This paper addresses the problem of separating spectral sources which are linearly mixed with unknown proportions. The main difficulty of the problem is to ensure the full additivity (sum-to-one) of the mixing coefficients and non-negativity of sources and mixing coefficients. A Bayesian estimation approach based on Gamma priors was recently proposed to handle the non-negativity constraints in a linear mixture model. However, incorporating the full additivity constraint requires further developments. This paper studies a new hierarchical Bayesian model appropriate to the non-negativity and sum…
A Bernoulli Mixture Model (BMM) is a finite mixture of random binary vectors with independent dimensions. The problem of clustering BMM data arises in a variety of real-world applications, ranging from population genetics to activity analysis in social networks. In this paper, we analyze the clusterability of BMMs from a theoretical perspective, when the number of clusters is unknown. In particular, we stipulate a set of conditions on the sample complexity and dimension of the model in order to guarantee the Probably Approximately Correct (PAC)-clusterability of a dataset. To the best of our k…
In this paper, we propose a data based transformation for infinite-dimensional Gaussian processes and derive its limit theorem. For a classification problem, this transformation induces complete separation among the associated Gaussian processes. The misclassification probability of any simple classifier when applied on the transformed data asymptotically converges to zero. In a clustering problem using mixture models, an appropriate modification of this transformation asymptotically leads to perfect separation of the populations. Theoretical properties are studied for the usual $k$-means clus…
University of Washington（华盛顿大学）；University of Pennsylvania（宾夕法尼亚大学）
We study the clustering task under anisotropic Gaussian Mixture Models where the covariance matrices from different clusters are unknown and are not necessarily the identical matrix. We characterize the dependence of signal-to-noise ratios on the cluster centers and covariance matrices and obtain the minimax lower bound for the clustering problem. In addition, we propose a computationally feasible procedure and prove it achieves the optimal rate within a few iterations. The proposed procedure is a hard EM type algorithm, and it can also be seen as a variant of the Lloyd's algorithm that is adj…
Mixture models are well-known for their versatility, and the Bayesian paradigm is a suitable platform for mixture analysis, particularly when the number of components is unknown. Bhattacharya (2008) introduced a mixture model based on the Dirichlet process, where an upper bound on the unknown number of components is to be specified. Here we consider a Bayesian asymptotic framework for objectively specifying the upper bound, which we assume to depend on the sample size. In particular, we define a Bayesian analogue of the mean integrated squared error (Bayesian MISE), and select that form of the…
The test of homogeneity for normal mixtures has been conducted in diverse research areas, but constructing a theory of the test of homogeneity is challenging because the parameter set for the null hypothesis corresponds to singular points in the parameter space. In this paper, we examine this problem from a new perspective and offer a theory of hypothesis testing for homogeneity based on a variational Bayes framework. In the conventional theory, the constant order term of the free energy has remained unknown, however, we clarify its asymptotic behavior because it is necessary for constructing …
The modelling of action potentials from extracellular recordings, or spike sorting, is a rich area of neuroscience research in which latent variable models are often used. Two such models, Overfitted Finite Mixture models (OFMs) and Dirichlet Process Mixture models (DPMs) are considered to provide insights for unsupervised clustering of complex, multivariate medical data when the number of clusters is unknown. OFM and DPM are structured in a similar hierarchical fashion but they are based on different philosophies with different underlying assumptions. This study investigates how these differe…
A natural Bayesian approach for mixture models with an unknown number of components is to take the usual finite mixture model with Dirichlet weights, and put a prior on the number of components---that is, to use a mixture of finite mixtures (MFM). While inference in MFMs can be done with methods such as reversible jump Markov chain Monte Carlo, it is much more common to use Dirichlet process mixture (DPM) models because of the relative ease and generality with which DPM samplers can be applied. In this paper, we show that, in fact, many of the attractive mathematical properties of DPMs are als…
We study frequentist risk properties of predictive density estimators for mean mixtures of multivariate normal distributions, involving an unknown location parameter $θ\in \mathbb{R}^d$, and which include multivariate skew normal distributions. We provide explicit representations for Bayesian posterior and predictive densities, including the benchmark minimum risk equivariant (MRE) density, which is minimax and generalized Bayes with respect to an improper uniform density for $θ$. For four dimensions or more, we obtain Bayesian densities that improve uniformly on the MRE density under Kullback…
Dirichlet process mixtures are flexible non-parametric models, particularly suited to density estimation and probabilistic clustering. In this work we study the posterior distribution induced by Dirichlet process mixtures as the sample size increases, and more specifically focus on consistency for the unknown number of clusters when the observed data are generated from a finite mixture. Crucially, we consider the situation where a prior is placed on the concentration parameter of the underlying Dirichlet process. Previous findings in the literature suggest that Dirichlet process mixtures are t…
We consider the problem of learning the weighted edges of a balanced mixture of two undirected graphs from epidemic cascades. While mixture models are popular modeling tools, algorithmic development with rigorous guarantees has lagged. Graph mixtures are apparently no exception: until now, very little is known about whether this problem is solvable. To the best of our knowledge, we establish the first necessary and sufficient conditions for this problem to be solvable in polynomial time on edge-separated graphs. When the conditions are met, i.e., when the graphs are connected with at least thr…
University of Minnesota（明尼苏达大学）；Oregon State University（俄勒冈州立大学）；University of Virginia（弗吉尼亚大学）；University of Florida（佛罗里达大学）
Linear mixture models have proven very useful in a plethora of applications, e.g., topic modeling, clustering, and source separation. As a critical aspect of the linear mixture models, identifiability of the model parameters is well-studied, under frameworks such as independent component analysis and constrained matrix factorization. Nevertheless, when the linear mixtures are distorted by an unknown nonlinear functions -- which is well-motivated and more realistic in many cases -- the identifiability issues are much less studied. This work proposes an identification criterion for a nonlinear m…
The problem is that of sequential probability forecasting for finite-valued time series. The data is generated by an unknown probability distribution over the space of all one-way infinite sequences. It is known that this measure belongs to a given set C, but the latter is completely arbitrary (uncountably infinite, without any structure given). The performance is measured with asymptotic average log loss. In this work it is shown that the minimax asymptotic performance is always attainable, and it is attained by a convex combination of a countably many measures from the set C (a Bayesian mixt…
Hamiltonian Monte Carlo (HMC) is an efficient method of simulating smooth distributions and has motivated the widely used No-U-turn Sampler (NUTS) and software Stan. We build on NUTS and the technique of "unbiased sampling" to design HMC algorithms that produce perfect simulation of general continuous distributions that are amenable to HMC. Our methods enable separation of Markov chain Monte Carlo convergence error from experimental error, and thereby provide much more powerful MCMC convergence diagnostics than current state-of-the-art summary statistics which confound these two errors. Object…
DNA samples crime cases analysed in forensic genetics, frequently contain DNA from multiple contributors. These occur as convolutions of the DNA profiles of the individual contributors to the DNA sample. Thus, in cases where one or more of the contributors were unknown, an objective of interest would be the separation, often called deconvolution, of these unknown profiles. In order to obtain deconvolutions of the unknown DNA profiles, we introduced a multiple population evolutionary algorithm (MEA). We allowed the mutation operator of the MEA to utilise that the fitness is based on a probabili…
Motivated by studies in biological sciences to detect differentially expressed genes, a semiparametric two-component mixture model with one known component is being studied in this paper. Assuming the density of the unknown component to be log-concave, which contains a very broad family of densities, we develop a semiparametric maximum likelihood estimator and propose an EM algorithm to compute it. Our new estimation method finds the mixing proportions and the distribution of the unknown component simultaneously. We establish the identifiability of the proposed semiparametric mixture model and…
