肌动蛋白水解和聚合的耦合：两种核苷酸状态的简化描述
Coupling of actin hydrolysis and polymerization: Reduced description with two nucleotide states
摘要：
肌动蛋白丝的聚合与三磷酸腺苷（ATP）的水解偶联，这涉及ATP的切割和无机磷酸盐的释放。我们描述了一个简化的两态模型与合作的裂解机制，其中的裂解率取决于相邻的肌动蛋白原聚体的状态在一个长丝水解。我们获得的理论预测实验可访问的稳态量，如ATP-肌动蛋白帽的大小，ATP-肌动蛋白岛的大小分布，和合作裂解机制的裂解通量。
英文摘要：
The polymerization of actin filaments is coupled to the hydrolysis of adenosine triphosphate (ATP), which involves both the cleavage of ATP and the release of inorganic phosphate. We describe hydrolysis by a reduced two-state model with a cooperative cleavage mechanism, where the cleavage rate depends on the state of the neighboring actin protomer in a filament. We obtain theoretical predictions of experimentally accessible steady state quantities such as the size of the ATP-actin cap, the size distribution of ATP-actin islands, and the cleavage flux for cooperative cleavage mechanisms.
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