偶联于ATP/GTP水解的纤维的非平衡自组装
Non-equilibrium self-assembly of a filament coupled to ATP/GTP hydrolysis
摘要：
我们研究的随机动态的增长和收缩的单个肌动蛋白丝或微管考虑到插入，删除，和ATP/GTP水解的亚基。所得到的相图包含三个不同的相：快速生长相、中间相和结合相。我们分析了所有这些阶段，重点是结合阶段。我们还讨论了水解如何影响力-速度曲线。束缚相表现出动态不稳定的特征，我们用ATP/GTP帽消失所需的时间以及细丝达到零长度所需的时间来表征，即，(to第一次崩溃。我们得到所有这些量的精确表达式，我们使用蒙特卡罗模拟测试。
英文摘要：
We study the stochastic dynamics of growth and shrinkage of single actin filaments or microtubules taking into account insertion, removal, and ATP/GTP hydrolysis of subunits. The resulting phase diagram contains three different phases: a rapidly growing phase, an intermediate phase and a bound phase. We analyze all these phases, with an emphasis on the bound phase. We also discuss how hydrolysis affects force-velocity curves. The bound phase shows features of dynamic instability, which we characterize in terms of the time needed for the ATP/GTP cap to disappear as well as the time needed for the filament to reach a length of zero, i.e., (to collapse) for the first time. We obtain exact expressions for all these quantities, which we test using Monte Carlo simulations.
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