穿细胞肽转导的简单模型
Simple Model of the Transduction of Cell-Penetrating Peptides
摘要：
细胞穿透肽（CPP）如HIV的反式激活转录激活因子（TAT）和聚精氨酸通过一种称为转导的未知机制快速穿过哺乳动物细胞的质膜。当与少于约35个氨基酸的精心选择的链融合时，它们在医学上是有用的。我提供了一个简单的模型，其中磷脂酰丝氨酸和CPP有效地形成两个板的电容器的电压足以导致形成瞬态孔（电穿孔）的转导。该模型是一致的寡聚精氨酸转导到小鼠C2-C12成肌细胞的实验数据，并作出三个可测试的预测。
英文摘要：
Cell-penetrating peptides (CPPs) such as HIV's trans-activating transcriptional activator (TAT) and polyarginine rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction. They may be medically useful when fused to well-chosen chains of fewer than about 35 amino acids. I offer a simple model of transduction in which phosphatidylserines and CPPs effectively form two plates of a capacitor with a voltage sufficient to cause the formation of transient pores (electroporation). The model is consistent with experimental data on the transduction of oligoarginine into mouse C2-C12 myoblasts and makes three testable predictions.
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