细胞穿透肽、电穿孔和药物递送
Cell-Penetrating Peptides, Electroporation, and Drug Delivery
摘要：
某些短聚阳离子，如TAT和寡聚精氨酸，通过称为转导的机制以及通过内吞作用和巨胞饮作用快速穿过哺乳动物细胞的质膜。这些细胞穿透肽（CPP）可以携带30个氨基酸的货物，超过500 Da的标称限度并且足以具有治疗性。对细胞膜外电荷的静电学分析和最近的一些实验表明，转导可以通过分子电穿孔进行。讨论了靶向病变细胞而不是所有细胞的方法。
英文摘要：
Certain short polycations, such as TAT and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis. These cell-penetrating peptides (CPPs) can carry with them cargos of 30 amino acids, more than the nominal limit of 500 Da and enough to be therapeutic. An analysis of the electrostatics of a charge outside the cell membrane and some recent experiments suggest that transduction may proceed by molecular electroporation. Ways to target diseased cells, rather than all cells, are discussed.
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