具有S形响应的生化过滤器：增加生物分子逻辑的复杂性
Biochemical Filter with Sigmoidal Response: Increasing the Complexity of Biomolecular Logic
摘要：
第一次实现的设计，而不是自然的，生化过滤过程的报告和分析作为一个有前途的网络组件，增加生物分子逻辑系统的复杂性。生物化学逻辑研究的关键挑战是实现复杂网络设计的可扩展性。已经实现了各种逻辑门，但是用于互连和信号处理的模拟元件的“工具箱”仍然难以捉摸。滤波器作为网络元件是重要的，其允许控制信号传输和转换中的噪声。我们报告了一个通用的生化过滤机制，旨在结合信号转换过程中的S形响应。辣根过氧化物酶催化的显色电子供体的过氧化氢的氧化，改变通过添加抗坏血酸，允许选择性地抑制输出信号，修改从凸形到S形的响应。建立了评价过滤质量的动力学模型。研究结果为设计可扩展的生物分子信息处理系统提供了改进的能力。
英文摘要：
The first realization of a designed, rather than natural, biochemical filter process is reported and analyzed as a promising network component for increasing the complexity of biomolecular logic systems. Key challenge in biochemical logic research has been achieving scalability for complex network designs. Various logic gates have been realized, but a "toolbox" of analog elements for interconnectivity and signal processing has remained elusive. Filters are important as network elements that allow control of noise in signal transmission and conversion. We report a versatile biochemical filtering mechanism designed to have sigmoidal response in combination with signal-conversion process. Horseradish peroxidase-catalyzed oxidation of chromogenic electron donor by hydrogen peroxide, was altered by adding ascorbate, allowing to selectively suppress the output signal, modifying the response from convex to sigmoidal. A kinetic model was developed for evaluation of the quality of filtering. The results offer improved capabilities for design of scalable biomolecular information processing systems.
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