对pH变化具有S形响应的生化过滤器：缓冲生物催化信号转导
Towards Biochemical Filter with Sigmoidal Response to pH Changes: Buffered Biocatalytic Signal Transduction
摘要：
我们通过在基于酶酯酶功能的生物催化信号转导逻辑系统中引入缓冲液来实现生化过滤过程。输入丁酸乙酯转化为丁酸-输出信号，其又通过pH值的下降来测量。所开发的方法提供了一个多功能的“网络元素”，以增加生物化学信息处理系统的复杂性。质量过滤的最佳制度的评价是在动力学速率方程模型的框架内完成的。
英文摘要：
We realize a biochemical filtering process by introducing a buffer in a biocatalytic signal-transduction logic system based on the function of an enzyme, esterase. The input, ethyl butyrate, is converted into butyric acid-the output signal, which in turn is measured by the drop in the pH value. The developed approach offers a versatile "network element" for increasing the complexity of biochemical information processing systems. Evaluation of an optimal regime for quality filtering is accomplished in the framework of a kinetic rate-equation model.
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