In this paper we present an efficient computer aided mass classification method in digitized mammograms using Artificial Neural Network (ANN), which performs benign-malignant classification on region of interest (ROI) that contains mass. One of the major mammographic characteristics for mass classification is texture. ANN exploits this important factor to classify the mass into benign or malignant. The statistical textural features used in characterizing the masses are mean, standard deviation, entropy, skewness, kurtosis and uniformity. The main aim of the method is to increase the effectiveness and efficiency of the classification process in an objective manner to reduce the numbers of false-positive of malignancies. Three layers artificial neural network (ANN) with seven features was proposed for classifying the marked regions into benign and malignant and 90.91% sensitivity and 83.87% specificity is achieved that is very much promising compare to the radiologist's sensitivity 75%.
Islamic Azad University-Khorasgan Branch（伊斯兰阿扎德大学霍尔斯加恩分校）；Amirkabir University of Technology（阿米尔卡比尔理工大学）
The appearance of microcalcifications in mammograms is one of the early signs of breast cancer. So, early detection of microcalcification clusters (MCCs) in mammograms can be helpful for cancer diagnosis and better treatment of breast cancer. In this paper a computer method has been proposed to support radiologists in detection MCCs in digital mammography. First, in order to facilitate and improve the detection step, mammogram images have been enhanced with wavelet transformation and morphology operation. Then for segmentation of suspicious MCCs, two methods have been investigated. The conside…
Breast tissue segmentation into dense and fat tissue is important for determining the breast density in mammograms. Knowing the breast density is important both in diagnostic and computer-aided detection applications. There are many different ways to express the density of a breast and good quality segmentation should provide the possibility to perform accurate classification no matter which classification rule is being used. Knowing the right breast density and having the knowledge of changes in the breast density could give a hint of a process which started to happen within a patient. Mammog…
Wolfson Institute of Preventive Medicine（沃尔夫森预防医学研究所）；Queen Mary University of London（伦敦玛丽女王大学）
Pectoral muscle identification is often required for breast cancer risk analysis, such as estimating breast density. Traditional methods are overwhelmingly based on manual visual assessment or straight line fitting for the pectoral muscle boundary, which are inefficient and inaccurate since pectoral muscle in mammograms can have curved boundaries. This paper proposes a novel and automatic pectoral muscle identification algorithm for MLO view mammograms. It is suitable for both scanned film and full field digital mammograms. This algorithm is demonstrated using a public domain software ImageJ. …
Mass classification of objects is an important area of research and application in a variety of fields. In this paper, we present an efficient computer aided mass classification method in digitized mammograms using Fuzzy K-Nearest Neighbor Equality, which performs benign or malignant classification on region of interest that contains mass. One of the major mammographic characteristics for mass classification is texture. Fuzzy K-Nearest Neighbor Equality exploits this important factor to classify the mass into benign or malignant. The statistical textural features used in characterizing the mas…
Currently Mammography is a most effective imaging modality used by radiologists for the screening of breast cancer. Finding an accurate, robust and efficient breast region segmentation technique still remains a challenging problem in digital mammography. Extraction of the breast profile region and the removal of pectoral muscle are essential pre-processing steps in Computer Aided Diagnosis (CAD) system for the diagnosis of breast cancer. Primarily it allows the search for abnormalities to be limited to the region of the breast tissue without undue influence from the background of the mammogram…
School of Information Technology and Electrical Engineering, University of Queensland（昆士兰大学信息技术与电气工程学院）
Mammographic mass detection and segmentation are usually performed as serial and separate tasks, with segmentation often only performed on manually confirmed true positive detections in previous studies. We propose a fully-integrated computer-aided detection (CAD) system for simultaneous mammographic mass detection and segmentation without user intervention. The proposed CAD only consists of a pseudo-color image generation and a mass detection-segmentation stage based on Mask R-CNN. Grayscale mammograms are transformed into pseudo-color images based on multi-scale morphological sifting where m…
Universidad del Caribe（加勒比大学）；Universidad Carlos III de Madrid（马德里卡洛斯三世大学）
Digital mammogram inspection is the most popular technique for early detection of abnormalities in human breast tissue. When mammograms are analyzed through a computational method, the presence of the pectoral muscle might affect the results of breast lesions detection. This problem is particularly evident in the mediolateral oblique view (MLO), where pectoral muscle occupies a large part of the mammography. Therefore, identifying and eliminating the pectoral muscle are essential steps for improving the automatic discrimination of breast tissue. In this paper, we propose an approach based on a…
National University of Singapore（新加坡国立大学）；Taipei Medical University（台北医学大学）；Nanyang Technological University（南洋理工大学）；Wan Fang Hospital（万芳医院）；Institute of Data Science（数据科学研究所）
The morphology and distribution of microcalcifications in a cluster are the most important characteristics for radiologists to diagnose breast cancer. However, it is time-consuming and difficult for radiologists to identify these characteristics, and there also lacks of effective solutions for automatic characterization. In this study, we proposed a multi-task deep graph convolutional network (GCN) method for the automatic characterization of morphology and distribution of microcalcifications in mammograms. Our proposed method transforms morphology and distribution characterization into node a…
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Shandong University（山东大学）；Guangdong General Hospital（广东省人民医院）；Guangdong Academy of Medical Sciences（广东省医学科学院）；Shanghai Jiao Tong University（上海交通大学）；The University of Sydney（悉尼大学）
Mammography is one of the most commonly applied tools for early breast cancer screening. Automatic segmentation of breast masses in mammograms is essential but challenging due to the low signal-to-noise ratio and the wide variety of mass shapes and sizes. Existing methods deal with these challenges mainly by extracting mass-centered image patches manually or automatically. However, manual patch extraction is time-consuming and automatic patch extraction brings errors that could not be compensated in the following segmentation step. In this study, we propose a novel attention-guided dense-upsam…
The Hong Kong University of Science and Technology（香港科技大学）
Automatic mammogram classification and mass segmentation play a critical role in a computer-aided mammogram screening system. In this work, we present a unified mammogram analysis framework for both whole-mammogram classification and segmentation. Our model is designed based on a deep U-Net with residual connections, and equipped with the novel hybrid deep supervision (HDS) scheme for end-to-end multi-task learning. As an extension of deep supervision (DS), HDS not only can force the model to learn more discriminative features like DS, but also seamlessly integrates segmentation and classifica…
In clinical practice, human radiologists actually review medical images with high resolution monitors and zoom into region of interests (ROIs) for a close-up examination. Inspired by this observation, we propose a hierarchical graph neural network to detect abnormal lesions from medical images by automatically zooming into ROIs. We focus on mammogram analysis for breast cancer diagnosis for this study. Our proposed network consist of two graph attention networks performing two tasks: (1) node classification to predict whether to zoom into next level; (2) graph classification to classify whethe…
Université de Bretagne Occidentale（西布列塔尼大学）；Inserm（法国国家健康与医学研究院）；IMT Atlantique（大西洋国立高等矿业电信学院）；University Hospital of Brest（布雷斯特大学医院）
Mammography is the primary imaging modality used for early detection and diagnosis of breast cancer. X-ray mammogram analysis mainly refers to the localization of suspicious regions of interest followed by segmentation, towards further lesion classification into benign versus malignant. Among diverse types of breast abnormalities, masses are the most important clinical findings of breast carcinomas. However, manually segmenting breast masses from native mammograms is time-consuming and error-prone. Therefore, an integrated computer-aided diagnosis system is required to assist clinicians for au…
University of Girona（赫罗纳大学）；University of Burgundy（勃艮第大学）
An advanced reliable low-cost form of screening method, Digital mammography has been used as an effective imaging method for breast cancer detection. With an increased focus on technologies to aid healthcare, Mammogram images have been utilized in developing computer-aided diagnosis systems that will potentially help in clinical diagnosis. Researchers have proved that artificial intelligence with its emerging technologies can be used in the early detection of the disease and improve radiologists' performance in assessing breast cancer. In this paper, we review the methods developed for mammogr…
Carleton University（卡尔顿大学）；National Research Council Canada（加拿大国家研究委员会）
Breast cancer is the most common cancer in women worldwide. The most common screening technology is mammography. To reduce the cost and workload of radiologists, we propose a computer aided detection approach for classifying and localizing calcifications and masses in mammogram images. To improve on conventional approaches, we apply deep convolutional neural networks (CNN) for automatic feature learning and classifier building. In computer-aided mammography, deep CNN classifiers cannot be trained directly on full mammogram images because of the loss of image details from resizing at input laye…
Automatic identification of patients with luminal and non-luminal subtypes during a routine mammography screening can support clinicians in streamlining breast cancer therapy planning. Recent machine learning techniques have shown promising results in molecular subtype classification in mammography; however, they are highly dependent on pixel-level annotations, handcrafted, and radiomic features. In this work, we provide initial insights into the luminal subtype classification in full mammogram images trained using only image-level labels. Transfer learning is applied from a breast abnormality…
Beijing Institute of Technology（北京理工大学）；Université 8 Mai 1945 Guelma（盖勒马8 Mai 1945大学）；National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College（中国医学科学院北京协和医学院肿瘤医院国家癌症中心国家肿瘤临床研究中心）
Mammography remains the most prevalent imaging tool for early breast cancer screening. The language used to describe abnormalities in mammographic reports is based on the breast Imaging Reporting and Data System (BI-RADS). Assigning a correct BI-RADS category to each examined mammogram is a strenuous and challenging task for even experts. This paper proposes a new and effective computer-aided diagnosis (CAD) system to classify mammographic masses into four assessment categories in BI-RADS. The mass regions are first enhanced by means of histogram equalization and then semiautomatically segment…
im3D S.p.A.（im3D股份公司）；APSS；KTH（瑞典皇家理工学院）；ISPO；Centro prevenzione oncologica（肿瘤预防中心）；IRCCS Policlinico San Donato（圣多纳托IRCCS医院）；ASLBi；IRCC；Regional Reference Centre for Breast Cancer Screening（乳腺癌筛查区域参考中心）；Ospedale Valduce（瓦尔杜切医院）；Ospedale S. Martino（圣马蒂诺医院）；C.d.C. Paideia；IRCCS, National Cancer Institute "G. Pascale" Foundation of Naples（那不勒斯G.帕斯卡尔国家癌症研究所IRCCS基金会）；AUSL；Ospedale Regionale（地区医院）；OIRM S.Anna（OIRM圣安娜医院）；Università degli Studi di Milano（米兰大学）
Objectives: To compare breast density (BD) assessment provided by an automated BD evaluator (ABDE) with that provided by a panel of experienced breast radiologists, on a multivendor dataset. Methods: Twenty-one radiologists assessed 613 screening/diagnostic digital mammograms from 9 centers and 6 different vendors, using the BI-RADS a, b, c, and d density classification. The same mammograms were also evaluated by an ABDE providing the ratio between fibroglandular and total breast area on a continuous scale and, automatically, the BI-RADS score. Panel majority report (PMR) was used as reference…
VinUniversity（文大大学）；Vinmec International Hospital（Vinmec国际医院）
The COVID-19 pandemic has exposed the vulnerability of healthcare services worldwide, raising the need to develop novel tools to provide rapid and cost-effective screening and diagnosis. Clinical reports indicated that COVID-19 infection may cause cardiac injury, and electrocardiograms (ECG) may serve as a diagnostic biomarker for COVID-19. This study aims to utilize ECG signals to detect COVID-19 automatically. We propose a novel method to extract ECG signals from ECG paper records, which are then fed into a one-dimensional convolution neural network (1D-CNN) to learn and diagnose the disease…
Age estimation has attracted attention for its various medical applications. There are many studies on human age estimation from biomedical images. However, there is no research done on mammograms for age estimation, as far as we know. The purpose of this study is to devise an AI-based model for estimating age from mammogram images. Due to lack of public mammography data sets that have the age attribute, we resort to using a web crawler to download thumbnail mammographic images and their age fields from the public data set; the Digital Database for Screening Mammography. The original images in…
Mammography is the most widely used gold standard for screening breast cancer, where, mass detection is considered as the prominent step. Detecting mass in the breast is, however, an arduous problem as they usually have large variations between them in terms of shape, size, boundary, and texture. In this literature, the process of mass detection is automated with the use of transfer learning techniques of Deep Convolutional Neural Networks (DCNN). Pre-trained VGG19 network is used to extract features which are then followed by bagged decision tree for features selection and then a Support Vect…
School of ITEE, The University of Queensland, Australia（昆士兰大学工学院（ITEE））；Sullivan Nicolaides Pathology, Australia（Sullivan Nicolaides病理实验室（澳大利亚））
This work tackles the automatic fine-grained slide quality assessment problem for digitized direct smears test using the Gram staining protocol. Automatic quality assessment can provide useful information for the pathologists and the whole digital pathology workflow. For instance, if the system found a slide to have a low staining quality, it could send a request to the automatic slide preparation system to remake the slide. If the system detects severe damage in the slides, it could notify the experts that manual microscope reading may be required. In order to address the quality assessment p…
Automatic art analysis has seen an ever-increasing interest from the pattern recognition and computer vision community. However, most of the current work is mainly based solely on digitized artwork images, sometimes supplemented with some metadata and textual comments. A knowledge graph that integrates a rich body of information about artworks, artists, painting schools, etc., in a unified structured framework can provide a valuable resource for more powerful information retrieval and knowledge discovery tools in the artistic domain. To this end, this paper presents ArtGraph: an artistic knowl…
Roche Innovation Center Munich（罗氏慕尼黑创新中心）；Technische Universität München（慕尼黑工业大学）；SagivTech LTD.（SagivTech有限公司）
A key challenge in cancer immunotherapy biomarker research is quantification of pattern changes in microscopic whole slide images of tumor biopsies. Different cell types tend to migrate into various tissue compartments and form variable distribution patterns. Drug development requires correlative analysis of various biomarkers in and between the tissue compartments. To enable that, tissue slides are manually annotated by expert pathologists. Manual annotation of tissue slides is a labor intensive, tedious and error-prone task. Automation of this annotation process can improve accuracy and cons…
Geisel School of Medicine at Dartmouth（达特茅斯盖泽尔医学院）；Dartmouth-Hitchcock Medical Center（达特茅斯-希契科克医疗中心）；Dartmouth College（达特茅斯学院）
Renal cell carcinoma (RCC) is the most common renal cancer in adults. The histopathologic classification of RCC is essential for diagnosis, prognosis, and management of patients. Reorganization and classification of complex histologic patterns of RCC on biopsy and surgical resection slides under a microscope remains a heavily specialized, error-prone, and time-consuming task for pathologists. In this study, we developed a deep neural network model that can accurately classify digitized surgical resection slides and biopsy slides into five related classes: clear cell RCC, papillary RCC, chromop…
Institute of Information Systems, HES-SO (University of Applied Sciences and Arts Western Switzerland)（瑞士西部应用科学与艺术大学 信息系统研究所）；Department of Computer Science, University of Geneva（日内瓦大学 计算机科学系）；Department of Neurosciences, University of Padua（帕多瓦大学 神经科学系）；Inselspital, Bern Hospital（伯尔尼大学医院）；Medical Faculty, University of Geneva（日内瓦大学 医学院）
Computational pathology is a domain that aims to develop algorithms to automatically analyze large digitized histopathology images, called whole slide images (WSI). WSIs are produced scanning thin tissue samples that are stained to make specific structures visible. They show stain colour heterogeneity due to different preparation and scanning settings applied across medical centers. Stain colour heterogeneity is a problem to train convolutional neural networks (CNN), the state-of-the-art algorithms for most computational pathology tasks, since CNNs usually underperform when tested on images in…
