Mammography is the most widely used gold standard for screening breast cancer, where, mass detection is considered as the prominent step. Detecting mass in the breast is, however, an arduous problem as they usually have large variations between them in terms of shape, size, boundary, and texture. In this literature, the process of mass detection is automated with the use of transfer learning techniques of Deep Convolutional Neural Networks (DCNN). Pre-trained VGG19 network is used to extract features which are then followed by bagged decision tree for features selection and then a Support Vector Machine (SVM) classifier is trained and used for classifying between the mass and non-mass. Area Under ROC Curve (AUC) is chosen as the performance metric, which is then maximized during classifier selection and hyper-parameter tuning. The robustness of the two selected type of classifiers, C-SVM, and \u{psion}-SVM, are investigated with extensive experiments before selecting the best performing classifier. All experiments in this paper were conducted using the INbreast dataset. The best AUC obtained from the experimental results is 0.994 +/- 0.003 i.e. [0.991, 0.997]. Our results conclude that by using pre-trained VGG19 network, high-level distinctive features can be extracted from Mammograms which when used with the proposed SVM classifier is able to robustly distinguish between the mass and non-mass present in breast.
State University of Ponta Grossa（蓬塔格罗萨州立大学）；Pontifical Catholic University of Paraná（巴拉那天主教大学）；Federal University of Parana（巴拉那联邦大学）
This work proposes a classification approach for breast cancer histopathologic images (HI) that uses transfer learning to extract features from HI using an Inception-v3 CNN pre-trained with ImageNet dataset. We also use transfer learning on training a support vector machine (SVM) classifier on a tissue labeled colorectal cancer dataset aiming to filter the patches from a breast cancer HI and remove the irrelevant ones. We show that removing irrelevant patches before training a second SVM classifier, improves the accuracy for classifying malign and benign tumors on breast cancer images. We are …
Mammography is often used as the most common laboratory method for the detection of breast cancer, yet associated with the high cost and many side effects. Machine learning prediction as an alternative method has shown promising results. This paper presents a method based on a multilayer fuzzy expert system for the detection of breast cancer using an extreme learning machine (ELM) classification model integrated with radial basis function (RBF) kernel called ELM-RBF, considering the Wisconsin dataset. The performance of the proposed model is further compared with a linear-SVM model. The propos…
India is agriculture based economy and sugarcane is one of the major crops produced in northern India. Productivity of sugarcane decreases due to inappropriate soil conditions and infections caused by various types of diseases , timely and accurate disease diagnosis, plays an important role towards optimizing crop yield. This paper presents a system model for monitoring of sugarcane crop, the proposed model continuously monitor parameters (temperature, humidity and moisture) responsible for healthy growth of the crop in addition KNN clustering along with SVM classifier is utilized for infectio…
Pixel based algorithms including back propagation neural networks (NN) and support vector machines (SVM) have been widely used for remotely sensed image classifications. Within last few years, deep learning based image classifier like convolution neural networks (2D-CNN) are becoming popular alternatives to these classifiers. In this paper, we compare performance of patch based SVM and NN with that of a deep learning algorithms comprising of 2D-CNN and fully connected layers. Similar to CNN which utilise image patches to derive features for further classification, we propose to use patches as …
Duke University（杜克大学）；Duke University Comprehensive Cancer Center（杜克大学综合癌症中心）
Purpose: To determine whether deep learning-based algorithms applied to breast MR images can aid in the prediction of occult invasive disease following the di- agnosis of ductal carcinoma in situ (DCIS) by core needle biopsy. Material and Methods: In this institutional review board-approved study, we analyzed dynamic contrast-enhanced fat-saturated T1-weighted MRI sequences of 131 patients at our institution with a core needle biopsy-confirmed diagnosis of DCIS. The patients had no preoperative therapy before breast MRI and no prior history of breast cancer. We explored two different deep lear…
Pakistan Navy Engineering College (PNEC)（巴基斯坦海军工程学院）；National University of Sciences & Technology (NUST)（国家科技大学）；Electronics and Power Engineering (EPE)（电子与动力工程系）
Technology aided platforms provide reliable tools in almost every field these days. These tools being supported by computational power are significant for applications that need sensitive and precise data analysis. One such important application in the medical field is Automatic Lesion Detection System (ALDS) for skin cancer classification. Computer aided diagnosis helps physicians and dermatologists to obtain a second opinion for proper analysis and treatment of skin cancer. Precise segmentation of the cancerous mole along with surrounding area is essential for proper analysis and diagnosis. …
In this work, we present a deep learning framework for multi-class breast cancer image classification as our submission to the International Conference on Image Analysis and Recognition (ICIAR) 2018 Grand Challenge on BreAst Cancer Histology images (BACH). As these histology images are too large to fit into GPU memory, we first propose using Inception V3 to perform patch level classification. The patch level predictions are then passed through an ensemble fusion framework involving majority voting, gradient boosting machine (GBM), and logistic regression to obtain the image level prediction. W…
Techno India University, West Bengal（西孟加拉邦Techno印度大学）
In this paper we present a novel method for an automated diagnosis of breast carcinoma through multilevel iterative variational mode decomposition (VMD) and textural features encompassing Zernaike moments, fractal dimension and entropy features namely, Kapoor entropy, Renyi entropy, Yager entropy features are extracted from VMD components. The proposed method considers the histopathological image as a set of multidimensional spatially-evolving signals. ReliefF algorithm is used to select the discriminatory features and statistically most significant features are fed to squares support vector m…
University of Washington（华盛顿大学）；University of Vermont（佛蒙特大学）
We trained and applied an encoder-decoder model to semantically segment breast biopsy images into biologically meaningful tissue labels. Since conventional encoder-decoder networks cannot be applied directly on large biopsy images and the different sized structures in biopsies present novel challenges, we propose four modifications: (1) an input-aware encoding block to compensate for information loss, (2) a new dense connection pattern between encoder and decoder, (3) dense and sparse decoders to combine multi-level features, (4) a multi-resolution network that fuses the results of encoder-dec…
The explosive availability of remote sensing images has challenged supervised classification algorithms such as Support Vector Machines (SVM), as training samples tend to be highly limited due to the expensive and laborious task of ground truthing. The temporal correlation and spectral similarity between multitemporal images have opened up an opportunity to alleviate this problem. In this study, a SVM-based Sequential Classifier Training (SCT-SVM) approach is proposed for multitemporal remote sensing image classification. The approach leverages the classifiers of previous images to reduce the …
Universidad de Granada（格拉纳达大学）；Memorial Sloan-Kettering Cancer Center（纪念斯隆-凯特琳癌症中心）；Medical University Vienna/AKH Wien（维也纳医科大学/维也纳总医院）；Florida State University（佛罗里达州立大学）
Non-mass enhancing lesions (NME) constitute a diagnostic challenge in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of the breast. Computer Aided Diagnosis (CAD) systems provide physicians with advanced tools for analysis, assessment and evaluation that have a significant impact on the diagnostic performance. Here, we propose a new approach to address the challenge of NME detection and segmentation, taking advantage of independent component analysis (ICA) to extract data-driven dynamic lesion characterizations. A set of independent sources was obtained from DCE-MRI dataset of …
Institute of Fundamental Technological Research, Polish Academy of Sciences（波兰科学院基础技术研究所）
Standard classification methods based on handcrafted morphological and texture features have achieved good performance in breast mass differentiation in ultrasound (US). In comparison to deep neural networks, commonly perceived as "black-box" models, classical techniques are based on features that have well-understood medical and physical interpretation. However, classifiers based on morphological features commonly underperform in the presence of the shadowing artifact and ill-defined mass borders, while texture based classifiers may fail when the US image is too noisy. Therefore, in practice …
Machine learning is widely used in developing computer-aided diagnosis (CAD) schemes of medical images. However, CAD usually computes large number of image features from the targeted regions, which creates a challenge of how to identify a small and optimal feature vector to build robust machine learning models. In this study, we investigate feasibility of applying a random projection algorithm to build an optimal feature vector from the initially CAD-generated large feature pool and improve performance of machine learning model. We assemble a retrospective dataset involving 1,487 cases of mamm…
A third level trigger programmable on FPGA for the gamma/hadron separation in a Cherenkov telescope using pseudo-Zernike moments and the SVM classifier
Warsaw University of Technology（华沙理工大学）；NYU Grossman School of Medicine（纽约大学格罗斯曼医学院）；New York University（纽约大学）；NYU Langone Health（纽约大学朗格尼医学中心）；Courant Institute（库朗研究所）
Deep neural networks (DNNs) show promise in breast cancer screening, but their robustness to input perturbations must be better understood before they can be clinically implemented. There exists extensive literature on this subject in the context of natural images that can potentially be built upon. However, it cannot be assumed that conclusions about robustness will transfer from natural images to mammogram images, due to significant differences between the two image modalities. In order to determine whether conclusions will transfer, we measure the sensitivity of a radiologist-level screenin…
Lehigh University（理海大学）；Keck School of Medicine, University of Southern California（南加州大学凯克医学院）
Background: Instagram, with millions of posts per day, can be used to inform public health surveillance targets and policies. However, current research relying on image-based data often relies on hand coding of images which is time consuming and costly, ultimately limiting the scope of the study. Current best practices in automated image classification (e.g., support vector machine (SVM), Backpropagation (BP) neural network, and artificial neural network) are limited in their capacity to accurately distinguish between objects within images. Objective: This study demonstrates how convolutional …
Università degli Studi di Cassino e del Lazio Meridionale（卡西诺与拉齐奥南部大学）
Identification and segmentation of breast masses in mammograms face complex challenges, owing to the highly variable nature of malignant densities with regards to their shape, contours, texture and orientation. Additionally, classifiers typically suffer from high class imbalance in region candidates, where normal tissue regions vastly outnumber malignant masses. This paper proposes a rigorous segmentation method, supported by morphological enhancement using grayscale linear filters. A novel cascaded ensemble of support vector machines (SVM) is used to effectively tackle the class imbalance and…
Universidade Federal Fluminense（弗鲁米嫩塞联邦大学）；Universidade Federal do Maranhao（马拉尼昂联邦大学）；York University（约克大学）
This paper examines the potential contribution of infrared (IR) imaging in breast diseases detection. It compares obtained results using some algorithms for detection of malignant breast conditions such as Support Vector Machine (SVM) regarding the consistency of different approaches when applied to public data. Moreover, in order to avail the actual IR imaging's capability as a complement on clinical trials and to promote researches using high-resolution IR imaging we deemed the use of a public database revised by confidently trained breast physicians as essential. Only the static acquisition…
University of Nevada, Reno（内华达大学里诺分校）；Advanced Robotics and Automation (ARA) Laboratory（先进机器人与自动化（ARA）实验室）
Accurate breast cancer diagnosis through mammography has the potential to save millions of lives around the world. Deep learning (DL) methods have shown to be very effective for mass detection in mammograms. Additional improvements of current DL models will further improve the effectiveness of these methods. A critical issue in this context is how to pick the right hyperparameters for DL models. In this paper, we present GA-E2E, a new approach for tuning the hyperparameters of DL models for brest cancer detection using Genetic Algorithms (GAs). Our findings reveal that differences in parameter…
Over the past decades, the hyperspectral remote sensing technology development has attracted growing interest among scientists in various domains. The rich and detailed spectral information provided by the hyperspectral sensors has improved the monitoring and detection capabilities of the earth surface substances. However, the high dimensionality of the hyperspectral images (HSI) is one of the main challenges for the analysis of the collected data. The existence of noisy, redundant and irrelevant bands increases the computational complexity, induce the Hughes phenomenon and decrease the target…
George Washington University（乔治华盛顿大学）；University of Waterloo（滑铁卢大学）；University of Toronto（多伦多大学）
This paper constructs a novel intelligent medical diagnosis system, which can realize automatic communication and breast cancer pathological image recognition. This system contains two main parts, including a pre-training chatbot called M-Chatbot and an improved neural network model of EfficientNetV2-S named EfficientNetV2-SA, in which the activation function in top layers is replaced by ACON-C. Using information retrieval mechanism, M-Chatbot instructs patients to send breast pathological image to EfficientNetV2-SA network, and then the classifier trained by transfer learning will return the …
Neuromation；Massachusetts Institute of Technology（麻省理工学院）；Lyft Inc.（Lyft公司）；University of Michigan（密歇根大学）
Breast cancer is one of the main causes of cancer death worldwide. Early diagnostics significantly increases the chances of correct treatment and survival, but this process is tedious and often leads to a disagreement between pathologists. Computer-aided diagnosis systems showed potential for improving the diagnostic accuracy. In this work, we develop the computational approach based on deep convolution neural networks for breast cancer histology image classification. Hematoxylin and eosin stained breast histology microscopy image dataset is provided as a part of the ICIAR 2018 Grand Challenge…
Institute of Radioelectronics and Multimedia Technology（无线电电子学与多媒体技术研究所）；Faculty of Electronics and Information Technology（电子与信息技术学院）；Warsaw University of Technology（华沙理工大学）
Several computer algorithms for recognition of visible human emotions are compared at the web camera scenario using CNN/MMOD face detector. The recognition refers to four face expressions: smile, surprise, anger, and neutral. At the feature extraction stage, the following three concepts of face description are confronted: (a) static 2D face geometry represented by its 68 characteristic landmarks (FP68); (b) dynamic 3D geometry defined by motion parameters for eight distinguished face parts (denoted as AU8) of personalized Candide-3 model; (c) static 2D visual description as 2D array of gray sc…
Universitas Pembangunan Nasional Veteran Yogyakarta（日惹退伍军人国立发展大学）
This study aims to identify chicken eggs fertility using the support vector machine (SVM) classifier method. The classification basis used the first-order statistical (FOS) parameters as feature extraction in the identification process. This research was developed based on the process's identification process, which is still manual (conventional). Although currently there are many technologies in the identification process, they still need development. Thus, this research is one of the developments in the field of image processing technology. The sample data uses datasets from previous studies…
Escola Politécnica, Universidade de São Paulo（圣保罗大学理工学院）；Instituto do Câncer do Estado de São Paulo（圣保罗州癌症研究所）；Faculdade de Medicina, Universidade de São Paulo（圣保罗大学医学院）
Some recent studies have described deep convolutional neural networks to diagnose breast cancer in mammograms with similar or even superior performance to that of human experts. One of the best techniques does two transfer learnings: the first uses a model trained on natural images to create a "patch classifier" that categorizes small subimages; the second uses the patch classifier to scan the whole mammogram and create the "single-view whole-image classifier". We propose to make a third transfer learning to obtain a "two-view classifier" to use the two mammographic views: bilateral craniocaud…
A Novel Approach to Breast Cancer Histopathological Image Classification Using Cross-Colour Space Feature Fusion and Quantum-Classical Stack Ensemble Method
National Institute of Technology, Kurukshetra（库鲁克谢特拉国家理工学院）
There are many challenges in the classification of hyper spectral images such as large dimensionality, scarcity of labeled data and spatial variability of spectral signatures. In this proposed method, we make a hybrid classifier (MLP-SVM) using multilayer perceptron (MLP) and support vector machine (SVM) which aimed to improve the various classification parameters such as accuracy, precision, recall, f-score and to predict the region without ground truth. In proposed method, outputs from the last hidden layer of the neural net-ork become the input to the SVM, which finally classifies into vari…
Charles Sturt University（查尔斯特大学）；University of Western Sydney（西悉尼大学）；Kent Institute Australia（肯特学院）；Asia Pacific International College（亚太国际学院）；Australian Institute of Higher Education（澳大利亚高等教育学院）；Al Iraqia University（伊拉克大学）；University of Kurdistan Hewler（库尔德斯坦赫勒大学）；AL Nisour University College（阿尔尼苏尔大学学院）
Background and Aim: Recently, deep learning using convolutional neural network has been used successfully to classify the images of breast cells accurately. However, the accuracy of manual classification of those histopathological images is comparatively low. This research aims to increase the accuracy of the classification of breast cancer images by utilizing a Patch-Based Classifier (PBC) along with deep learning architecture. Methodology: The proposed system consists of a Deep Convolutional Neural Network (DCNN) that helps in enhancing and increasing the accuracy of the classification proce…
We proposed a novel convolutional restricted Boltzmann machine CRBM-based radiomic method for predicting pathologic complete response (pCR) to neoadjuvant chemotherapy treatment (NACT) in breast cancer. The method consists of extracting semantic features from CRBM network, and pCR prediction. It was evaluated on the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data of 57 patients and using the area under the receiver operating characteristic curve (AUC). Traditional radiomics features and the semantic features learned from CRBM network were extracted from the images acquired …
Traditional breast cancer image classification methods require manual extraction of features from medical images, which not only require professional medical knowledge, but also have problems such as time-consuming and labor-intensive and difficulty in extracting high-quality features. Therefore, the paper proposes a computer-based feature fusion Convolutional neural network breast cancer image classification and detection method. The paper pre-trains two convolutional neural networks with different structures, and then uses the convolutional neural network to automatically extract the charact…
Center for Data Science, New York University（纽约大学数据科学中心）；Department of Computer Science, Courant Institute, New York University（纽约大学库朗研究所计算机科学系）；Department of Radiology, NYU School of Medicine（纽约大学医学院放射科）；Perlmutter Cancer Center, NYU Langone Health（纽约大学朗格尼健康系统珀尔马特癌症中心）；Center for Advanced Imaging Innovation and Research, NYU Langone Health（纽约大学朗格尼健康系统先进成像创新与研究中心）；CIFAR Associate Fellow（CIFAR研究员（注：CIFAR是加拿大英属哥伦比亚大学的一个研究机构，但根据提取规则，此处仅提取“CIFAR”相关部分，严格按英文保留））
Medical images differ from natural images in significantly higher resolutions and smaller regions of interest. Because of these differences, neural network architectures that work well for natural images might not be applicable to medical image analysis. In this work, we extend the globally-aware multiple instance classifier, a framework we proposed to address these unique properties of medical images. This model first uses a low-capacity, yet memory-efficient, network on the whole image to identify the most informative regions. It then applies another higher-capacity network to collect detail…
Melanoma is the most dangerous form of skin cancer, which is responsible for the majority of skin cancer-related deaths. Early diagnosis of melanoma can significantly reduce mortality rates and treatment costs. Therefore, skin cancer specialists are using image-based diagnostic tools for detecting melanoma earlier. We aim to develop a handheld device featured with low cost and high performance to enhance early detection of melanoma at the primary healthcare. But, developing this device is very challenging due to the complicated computations required by the embedded diagnosis system. Thus, we a…
AP-HP（巴黎公立医院集团）；Hôpital de la Pitié-Salpêtrière（皮蒂-萨尔皮特里医院）；Sorbonne Universités（索邦大学）；UPMC Univ Paris 06（巴黎第六大学（皮埃尔和玛丽·居里大学））；Inserm（法国国家健康与医学研究院）；CNRS（法国国家科学研究中心）；ICM（脑与脊髓研究所）；Inria（法国国家信息与自动化研究所）；Laboratoire Bordelais de Recherche en Informatique（波尔多计算机科学实验室）；Brainreader；AXA Research Fund（安盛研究基金）；Pierre et Marie Curie University（皮埃尔和玛丽·居里大学）
BACKGROUND:Automated volumetry software (AVS) has recently become widely available to neuroradiologists. MRI volumetry with AVS may support the diagnosis of dementias by identifying regional atrophy. Moreover, automatic classifiers using machine learning techniques have recently emerged as promising approaches to assist diagnosis. However, the performance of both AVS and automatic classifiers has been evaluated mostly in the artificial setting of research datasets.OBJECTIVE:Our aim was to evaluate the performance of two AVS and an automatic classifier in the clinical routine condition of a mem…
New York University（纽约大学）；NYU School of Medicine（纽约大学医学院）；NYU Langone Medical Center（纽约大学朗格尼医学中心）
Breast density classification is an essential part of breast cancer screening. Although a lot of prior work considered this problem as a task for learning algorithms, to our knowledge, all of them used small and not clinically realistic data both for training and evaluation of their models. In this work, we explore the limits of this task with a data set coming from over 200,000 breast cancer screening exams. We use this data to train and evaluate a strong convolutional neural network classifier. In a reader study, we find that our model can perform this task comparably to a human expert.
Institute of Fundamental Technological Research, Polish Academy of Sciences（波兰科学院基础技术研究所）；University of California, San Diego（加州大学圣迭戈分校）
Morphological features play an important role in breast mass classification in sonography. While benign breast masses tend to have a well-defined ellipsoidal contour, shape of malignant breast masses is commonly ill-defined and highly variable. Various handcrafted morphological features have been developed over the years to assess this phenomenon and help the radiologists differentiate benign and malignant masses. In this paper we propose an automatic approach to morphology analysis, we express shapes of breast masses as points on the Kendall's shape manifold. Next, we use the full Procrustes …
Alleviating Hyperparameter-Tuning Burden in SVM Classifiers for Pulmonary Nodules Diagnosis with Multi-Task Bayesian Optimization
Yau Mathematical Sciences Center Tsinghua University（姚数学科学中心清华大学）；The First Affiliated Hospital of Guangzhou Medical University（广州医科大学第一附属医院）；China State Key Laboratory of Respiratory Disease（中国呼吸疾病国家重点实验室）；Academy of Mathematics and Systems Science Chinese Academy of Sciences（数学科学学院中国科学院）；University of Chinese Academy of Sciences（中国科学院大学）；Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical University（胸外科与肿瘤科广州医科大学第一附属医院）
Classifier Enhanced Deep Learning Model for Erythroblast Differentiation with Limited Data
Koita Centre for Digital Health, Indian Institute of Technology Bombay（印度理工学院孟买分校科伊塔数字健康中心）；Zoho Corporation（卓豪公司）；Department of Chemical Engineering, Indian Institute of Technology Bombay（印度理工学院孟买分校化学工程系）；Sensing and Monitoring Foundation（传感与监测基金会）
Automating tumor-infiltrating lymphocyte assessment in breast cancer histopathology images using QuPath: a transparent and accessible machine learning pipeline
UiT The Arctic University of Norway（挪威北极圈大学）；University Hospital of North Norway（挪威北部大学医院）
