Cyclinac Medical Accelerators Using Pulsed C6+/H2+ Ion Sources
A. Garonna, U. Amaldi, R. Bonomi, D. Campo, A. Degiovanni, M. Garlasché, I. Mondino, V. Rizzoglio, S. Verdú Andrés
备注：
Submitted to Journal of Instrumentation, as proceedings of EBIST2010 (25 June 2010) 13 pages, 8 figures Revised version submitted on 11 August 2010, 18 pages, 9 figures
Charged particle therapy, or so-called hadrontherapy, is developing very rapidly. There is large pressure on the scientific community to deliver dedicated accelerators, providing the best possible treatment modalities at the lowest cost. In this context, the Italian research Foundation TERA is developing fast-cycling accelerators, dubbed 'cyclinacs'. These are a combination of a cyclotron (accelerating ions to a fixed initial energy) followed by a high gradient linac boosting the ions energy up to the maximum needed for medical therapy. The linac is powered by many independently controlled klystrons to vary the beam energy from one pulse to the next. This accelerator is best suited to treat moving organs with a 4D multi-painting spot scanning technique. A dual proton/carbon ion cyclinac is here presented. It consists of an Electron Beam Ion Source, a superconducting isochronous cyclotron and a high-gradient linac. All these machines are pulsed at high repetition rate (100-400 Hz). The source should deliver both C6+ and H2+ ions in short pulses (1.5 μs flat-top) and with sufficient intensity (at least 108 fully stripped carbon ions at 300 Hz). The cyclotron accelerates the ions to 120 MeV/u. It features a compact design (with superconducting coils) and a low power consumption. The linac has a novel C-band high gradient structure and accelerates the ions to variable energies up to 400 MeV/u. High RF frequencies lead to power consumptions which are much lower than the ones of synchrotrons for the same ion extraction energy. This work is part of a collaboration with the CLIC group, which is working at CERN on high-gradient electron-positron colliders.
We propose an innovative fast-cycling accelerator complex conceived and designed to exploit at best the properties of accelerated ion beams for hadrontherapy. A cyclinac is composed by a cyclotron, which can be used also for other valuable medical and research purposes, followed by a high gradient linear accelerator capable to produce ion beams optimized for the irradiation of solid tumours with the most modern techniques. The properties of cyclinacs together with design studies for protons and carbon ions are presented and the advantages in facing the challenges of hadrontherapy are discussed…
Compact, reliable and little consuming accelerators are required for the treatment of tumours with ions. TERA proposes the "cyclinac", composed of a high-frequency, fast-cycling linac which boosts the energy of the particles previously accelerated in a cyclotron. The dimensions of the linac can be reduced if high gradients are used. TERA initiated a high-gradient test program to understand the operational limit of such structures. The program foresees the design, prototyping and high-power test of several high-gradient structures operating at 3 and 5.7 GHz. The high-power tests of the 3 GHz si…
We propose an innovative linear accelerating structure, particularly suited for hadrontherapy applications. Its two main features are compactness and good power efficiency at low beam velocities: the first is achieved through a high working frequency and a consequent high accelerating gradient, the second is obtained by coupling several H-mode cavities together. The structure is called CLUSTER, which stands for "Coupled-cavity Linac USing Transverse Electric Radial field". In order to compare the performance of this structure with other hadrontherapy linac designs involving high frequencies, a…
The 3 MV Tandem Pelletron accelerator at the Spanish Accelerator Laboratory (CNA) has been recently upgraded to produce pulsed ion beams for neutron Time-Of-Flight (TOF) measurements. The upgrade has consisted of two actions: a pulsing system installed at the low energy part of the Tandem accelerator and a new line fully equipped. The pulsing system provides approximately one nanosecond pulse width of protons with variable repetition rates from kHz down to MHz. The new line is equipped with conventional devices and a pick-up for timing measurements with high resolution. The properties of the w…
In this paper, a novel concept combining a fixed field alternating gradient accelerator with time-varying quadrupoles is presented which solves some of the major problems of conventional fixed field accelerators. This concept combines a stable racetrack fixed field configuration with dispersion free straight sections to enable continuous variable energy extraction. In the long straight sections, a time-varying synchrotron-like alternating gradient focusing structure makes it possible for the first time to correct the beam optics of an FFA accelerator in order to heuristically maximize the beam…
We report on updates to the accelerator controls for the Neutralized Drift Compression Experiment II, a pulsed induction-type accelerator for heavy ions. The control infrastructure is built around a LabVIEW interface combined with an Apache Cassandra backend for data archiving. Recent upgrades added the storing and retrieving of device settings into the database, as well as ZeroMQ as a message broker that replaces LabVIEW's shared variables. Converting to ZeroMQ also allows easy access via other programming languages, such as Python.
The Pohang Accelerator Laboratory operates an electron linac for the pulsed neutron source as one of the long-term nuclear R&D programs at the Korea Atomic Energy Research Institute. The designed beam parameters are as follows; The nominal beam energy is 100 MeV, the maximum beam power is 10 kW, and the beam current is varied from 300 mA to 5A depends on the pulse repetition. The linac has two operating modes: one for short pulse modes with the various repetitions between 2 ns and 100 ns and the other for long pulse modes with 1 ms repetition. We have constructed and tested an electron linac b…
A neutron source is proposed. It is based on a proton accelerator with the energy Ep = 1.2 GeV, current Ip = 0.7A, pulse duration T = 3 mcsec, repetition rate F = 60 Hz, and accelerator length L = 30 m. Protons are accelerated by the field of electron rings. The electron rings are formed from a tube beam by way of modulation and creating rotating motion by crossing the magnetic field cusp. The frequency of modulation f1 = 142.8 MHz. The bunch is accelerated at the frequency f3 = 2856 MHz. The high frequency power required for making the field is P1 = 6 - 150 MW/section, the power transferred t…
The article considers an opportunity of pulsed acceleration of the proton beam in a spiral wave guide. The radial focus of the proton beam in the accelerator is carried out by means of the magnetic field of ten Tesla, generated by a superconducting solenoid.
The 75-keV injector and 6.7-MeV RFQ that comprise the first portion of the cw, 100-mA proton linac for the accelerator production of tritium (APT) project have been built and operated. The LEDA RFQ has been extensively tested for pulsed and cw output-beam currents <=100 mA. Up to 2.2 MW of cw rf power from the 350-MHz rf system is coupled into the RFQ, including 670 kW for the cw proton beam. The emittance for a 93-mA pulsed RFQ output beam, as determined from quadrupole-magnet-scan measurements, is ex x ey = 0.25 x 0.31 (pi mm mrad)2 [rms normalized]. A follow-on experiment, to intentionally …
The superconducting (SC) proton linac is proposed in the JAERI/KEK Joint Project for a high-intensity proton accelerator in the energy region from 400 to 600 MeV. Highly stable fields in the SC cavities are required under the dynamic Lorentz force detuning. A new model describing the dynamic Lorentz detuning has been developed and the validity has been confirmed experimentally. The model has been applied successfully to the rf control simulation of the SC proton linac.
As part of the R&D toward the production of high flux of polarised Gamma-rays we have designed and built a non-planar four-mirror optical cavity with a high finesse and operated it at a particle accelerator. We report on the main challenges of such cavity, such as the design of a suitable laser based on fiber technology, the mechanical difficulties of having a high tunability and a high mechanical stability in an accelerator environment and the active stabilization of such cavity by implementing a double feedback loop in a FPGA.
UHDpulse - Metrology for Advanced Radiotherapy using beams with Ultra-High Pulse Dose Rates is a European project aimed at developing novel dosimetry standards, as well as improving existing ones, for FLASH radiotherapy, very high energy electrons radiotherapy, and laser-driven medical accelerators. Within the scope of this project, Thermoluminescence (TL) and Optically Stimulated Luminescence (OSL) detectors are used to measure stray radiation fields. Experiments performed with conventional pulsed particle-beams allow to characterize the dosimeters in known and controllable radiation fields. …
Gaining in-situ access to relaxation dynamics of radiation induced defects will lead to a better understanding of materials and is important for the verification of theoretical models and simulations. We show preliminary results from experiments at the new Neutralized Drift Compression Experiment (NDCX-II) at Lawrence Berkeley National Laboratory that will enable in-situ access to defect dynamics through pump-probe experiments. Here, the unique capabilities of the NDCX-II accelerator to generate intense, nanosecond pulsed ion beams are utilized. Preliminary data of channeling experiments using…
The concept of large-radius multistage coaxial cyclotrons having separated orbits is described, to generate proton beams of 120-2000 MeV energy at tens of GW pulsed and hundreds of MW in continuous beam power operation. Accelerated beam losses must be less than 0.1 W/m for the intercepted average beam power linear density. The concept is inherently configured to actively compensate the longitudinal and transverse space charge expansion in beam bunches. These are based on (1) actively varying the bunch acceleration equilibrium phase while maintaining isochronism, independently for each cyclotro…
The velocity of neutrons from a pulsed neutron source is well-defined as a function of their arrival time. Electromagnetic neutron accelerator/decelerator synchronized with the neutron time-of-flight is capable of selectively changing the neutron velocity and concentrating the velocity distribution. Possible enhancement of the neutron intensity at a specific neutron velocity by orders of magnitude is discussed together with an experimental design.
We describe and discuss solutions for an innovating sub-relativistic electron source, based on pulsed DC gun, including linear (1D) Field Emitter Array (FEA) associated immediately with Laser Dielectric Accelerator (DLA) stage. That setup is designed to avoid any standard accelerator component (electrostatic or magnetic macroscopic dipole ...) Parts of the diagnostics, including spectrometer and all diagnostics, are planned to rely on nano-structures. Then the entire setup -pulsed source, laser and measurements ends excepted- should be enclosed inside a decimeter range vacuum chamber. The goal…
The code SCREAM -- SuperConducting RElativistic particle Accelerator siMulation was significantly modified and improved. Some misprints in the formulae used have been fixed and a more realistic expression for the vector-sum introduced. The realistic model of Lorentz-force detuning (LFD) is developed and will be implemented to the code. A friendly GUI allows various parameters of the simulated problem to be changed easily and quickly. Effective control of various output data is provided. A change of various parameters during the simulation process is controlled by plotting the corresponding gra…
The article considers an opportunity of simultaneous pulsed acceleration of seven proton beams with current one hundred milliamps in each beam. The accelerator consists of two parts. In the first part of the accelerator having the length five meters, the protons are accelerated to the energy of mega electron Volts. Consumption of high-frequency power by this part of the accelerator is equal to mega Watts. In the second part of the accelerator having the length fifty meters, the protons are accelerated to the finite energy eighty mega electron Volts. Consumption of the high frequency power by t…
We consider acceleration of protons in a cavity with such dimensions as length l = 10 m, width b = 20 m, height a = 1.01 m, located between two bending (180)degree magnets with isochronous magnetic field. The cavity is loaded with rows of drift plates (tubes), being excited by a wave of E110 type at the frequency fo = 148.5 MHz, excitation power P1 = 5.65 MW. Additionally, the cavity is fed with the power P2 = 8 MW, transmitted into a beam of protons with such parameters as the final energy 0.8 GeV, pulse beam current I = 10 mA, pulse width 25 microseconds, repetition rate 10 Hz. We discuss th…
Bridging Metal Additive Manufacturing and RF Accelerator Design: Development of a 704.4 MHz Crossbar H-Mode Linac for Efficient Beam Acceleration
GSI Helmholtzzentrum für Schwerionenforschung（GSI亥姆霍兹重离子研究中心）；Institute for Applied Physics, Goethe-University Frankfurt（法兰克福歌德大学应用物理研究所）；Helmholtz Research Academy Hesse for FAIR（黑森亥姆霍兹FAIR研究院）
Modern CW or pulsed superconducting accelerators of megawatts beams require efficient RF sources controllable in phase and power. It is desirable to have an individual RF power source with power up to hundreds of kW for each Superconductive RF (SRF) cavity. For pulsed accelerators the pulse duration in millisecond range is required. The efficiency of the traditional RF sources (klystrons, IOTs, solid-state amplifiers) in comparison to magnetrons is lower and the cost of unit of RF power is significantly higher. Typically, the cost of RF sources and their operation is a significant part of the …
The next generation of high-energy physics experiments requires high intensity protons in the multi-GeV energy range for efficient production of secondary beams. The Fermilab long-term future requires an 8 GeV proton source to feed the Main Injector for a 2 MW neutrino beam source in the immediate future and to provide 4 MW pulsed proton beam for a future neutrino factory or muon collider. We note that a 3GeV cw linac matched to a 3---8GeV FFAG ring could provide beam for both of these mission needs, as well as the cw 3GeV experiments, and would be a natural and affordable scenario. We present…
Canada recently lost its major supply of neutron beams with the closure of the National Research Universal reactor at Chalk River Laboratories in March 2018. This issue is further exacerbated by the closure of other reactors abroad, which also served as centers for neutron research. Consequently, there is a demand for new sources, both for Canada and internationally, as the global supply shrinks. Compact accelerator driven neutron sources provide an avenue to realize an intense source of pulsed neutron beams, with a capital cost significantly lower than spallation sources. In an effort to clos…
A novel concept of a high-power magnetron transmitter allowing dynamic phase and power control at the frequency of locking signal is proposed. The transmitter compensating parasitic phase and amplitude modulations inherent in Superconducting RF (SRF) cavities within closed feedback loops is intended for powering of the intensity-frontier superconducting accelerators. The concept uses magnetrons driven by a sufficient resonant (injection-locking) signal and fed by the voltage which can be below the threshold of self-excitation. This provides an extended range of power control in a single magnet…
Spallation source dedicated for neutron scattering experiments, as well as multi-purpose facilities serving several applications call for pulsed mode operation of a high intensity proton linac. There is general agreement on the superconducting technology for the high-energy part, which offers some advantages, like higher gradient capabilities or operational costs reduction, as compared to room-temperatures accelerating structures. This mode of operation however could spoil the energy stability of the proton beam and needs thus to be carefully studied. First, transient beam-loading effects, ari…
Results from the Modified Three Gradient Method (MTGM), applied to a pulsed high intensity electron source, are presented. The MTGM makes possible the non-destructive determination of beam emittance in the space charge presence [1]. We apply the MTGM to an experimental system equipped with a Pierce convergent diode, working in pulse mode, and having a directly heated cathode as electron source. This choice was mainly motivated by the availability of an analytical characterization of this source type [2], as well as the extended use of the Pierce type sources in linear accelerators. The experim…
We convert a GeV laser-plasma electron accelerator into a compact femtosecond-pulsed $γ$-ray source by inserting a $100 μ$m-thick glass plate $\sim3$ cm after the accelerator exit. With near-unity reliability, and requiring only crude alignment, this glass plasma mirror retro-reflected spent drive laser pulses (photon energy $\hbarω_L = 1.17$ eV) with $>50\%$ efficiency back onto trailing electrons (peak Lorentz factor $1000 < γ_e < 4400$), creating an optical undulator that generated $\sim10^8 γ$-ray photons with sub-mrad divergence, estimated peak brilliance $\sim10^{21}$ photons/s/mm$^2$/mr…
The H- Accelerator consists of a 750 keV Cockcroft Walton preaccelerator and an Alvarez type 50 MeV linac. The accelerator has been in operation since 1961. Since 1981, it has been used as the injector for the Intense Pulsed Neutron Source (IPNS), a national user facility for neutron scattering. The linac delivers about 3.5x1012 H- ions per pulse, 30 times per second (30 Hz), for multi-turn injection to a 450 MeV Rapid Cycling Synchrotron (RCS). IPNS presently operates about 4,000 hours per year, and operating when scheduled is critical to meeting the needs of the user community. For many year…
The Electron String type of Ion Sources (ESIS) was developed, constructed and tested first in the Joint Institute for Nuclear Research. These ion sources can be the appropriate sources for production of pulsed C4+ and C6+ ion beams which can be used for cancer therapy accelerators. In fact the test ESIS Krion-6T already now at the solenoid magnetic field only 4.6 T provides more than 10^10 C4+ ions per pulse and about 5*10^9 C6+ ions per pulse. Such ion sources could be suitable for application at synchrotrons. It was also found, that Krion-6T can provide more than 10^11 C6+ ions per second at…
A review of modern high intensity H- ion sources for accelerators is presented. The cesiation effect, a significant enhancement of negative ion emission from gas discharges with decrease of co-extracted electron current below negative ion current, was observed for the first time by inserting into the discharge chamber a compound with one milligram of cesium on July 1, 1971 in the Institute of Nuclear Physics (INP), Novosibirsk, Russia. This observation became the basis for the development of surface plasma negative ion sources (SPS). The efficiency of negative ion generation was increased by t…
A concept of a 650 MHz CW magnetron transmitter with fast control in phase and power, based on two-stage injection-locked CW magnetrons, has been proposed to drive Superconducting Cavities (SC) for intensity-frontier accelerators. The concept is based on a theoretical model considering a magnetron as a forced oscillator and experimentally verified with a 2.5 MW pulsed magnetron. To fulfill fast control of phase and output power requirements of SC accelerators, both two-stage injection-locked CW magnetrons are combined with a 3-dB hybrid. Fast control in output power is achieved by varying the …
The widespread use of high energy particle beams in basic research, medicine and coherent X-ray generation coupled with the large size of modern radio frequency (RF) accelerator devices and facilities has motivated a strong need for alternative accelerators operating in regimes outside of RF. Working at optical frequencies, dielectric laser accelerators (DLAs) - transparent laser-driven nanoscale dielectric structures whose near fields can synchronously accelerate charged particles - have demonstrated high-gradient acceleration with a variety of laser wavelengths, materials, and electron beam …
The cost, size and availability of electron accelerators is dominated by the achievable accelerating gradient. Conventional high-brightness radio-frequency (RF) accelerating structures operate with 30-50 MeV/m gradients. Electron accelerators driven with optical or infrared sources have demonstrated accelerating gradients orders of magnitude above that achievable with conventional RF structures. However, laser-driven wakefield accelerators require intense femtosecond sources and direct laser-driven accelerators and suffer from low bunch charge, sub-micron tolerances and sub-femtosecond timing …
A CW-compatible, pulsed H- superconducting linac is envisaged as a possible path for upgrading Fermilab's injection complex. To validate the concept of the front- end of such a machine, a test accelerator (a.k.a. PXIE) is under construction. The warm part of this accelerator comprises a 10 mA DC, 30 keV H- ion source, a 2m-long LEBT, a 2.1 MeV CW RFQ, and a 10-m long MEBT that is capable of creating a large variety of bunch structures. The paper will report commissioning results of a partially assembled LEBT, status of RFQ manufacturing, and describe development of the MEBT, in particular, of …
Fast switching (< 10 nsec) measurement results on the recently developed BST(M) (barium strontium titanium oxide composition with magnesium-based additions) ferroelectric materials are presented. These materials can be used as the basis for new advanced technology components suitable for high-gradient accelerators. A ferroelectric ceramic has an electric field-dependent dielectric permittivity that can be altered by applying a bias voltage. Ferroelectric materials offer significant benefits for linear collider applications, in particular, for switching and control elements where a very short r…
Significant transient beam loading effects were observed during beam commissioning tests of prototype II of the injector for the Accelerator Driven Sub-critical (ADS) system, which took place at the Institute of Modern Physics, Chinese Academy of Sciences, between October and December 2014. During these tests experiments were performed with CW operation of the cavities with pulsed beam current, and the system was configured to make use of a prototype digital low level radio frequency (LLRF) controller. The system was originally operated in pulsed mode with a simple PID feedback control algorit…
A CW-compatible, pulsed H- superconducting linac "PIP-II" is being planned to upgrade Fermilab's injection complex. To validate the front-end concept, a test accelerator (The PIP-II Injector Test, formerly known as "PXIE") is under construction. The warm part of this accelerator comprises a 10 mA DC, 30 keV H- ion source, a 2 m-long Low Energy Beam Transport (LEBT), a 2.1 MeV Radio Frequency Quadrupole (RFQ) capable of operation in Continuous Wave (CW) mode, and a 10 m-long Medium Energy Beam Transport (MEBT). The paper will report on the installation of the RFQ and the first sections of the M…
Typical front-ends of modern light-ion high-intensity accelerators typically consist of an ion source, a Low Energy Beam Transport (LEBT), a Radiofrequency Quadrupole (RFQ) and a Medium Energy Beam Transport (MEBT), which is followed by the main linac accelerating structures. Over the years, many LEBTs have been designed, constructed and operated very successfully. In this paper, we present the guiding principles and compromises that lead to the design choices of the PXIE LEBT, including the rationale for a beam line that allows un-neutralized transport over a significant portion of the LEBT w…
Building an accelerator at six geographically dispersed sites is quite mad, but politically expedient. The Spallation Neutron Source (SNS), currently under construction in Oak Ridge, Tennessee, combines a pulsed 1 Gev H- superconducting linac with a compressor ring to deliver 2MW of beam power to a liquid mercury target for neutron production [1]. Accelerator components, target and experimental (neutron-scattering) instruments are being developed collaboratively by Lawrence Berkeley (Ion Source and Front End), Los Alamos (Linac), Thomas Jefferson (Cryosystems), Brookhaven (Compressor Ring), Oa…
We report here a systematic quantitative study on generation and characteristics of an active muon source driven by the interaction of an electron beam within the energy range of 1 to 10 GeV from laser wakefield acceleration (LWFA) with a tungsten target, using Monte Carlo simulations. The 10GeV electron beam, achievable in near future, from LWFA using femtosecond multi-PW lasers is employed to drive the bright source of muon pairs in a compact setup. We show that a highly directional and intense source of short-pulsed GeV muon pairs having peak brightness 5x10^17 pairs/s/cm^2/sr and sub-100-p…
In order to dissipate long-lived radioactive waste, not only high ux proton accelerator but also electron linac have been proposed. A proton accelerator directly induces nuclear fission and mutation. On the other hand, electron beam has two processes: production of gamma rays through bremsstrahlung and produced gamma rays are available for the (gamma ; n) reaction. Protons dissipate nuclei and simultaneously newly produce radioisotopes of by-products. Since an electron linac produces less radioactive wastes, we focus only an electron linac with high beam intensity more than 1-Ampere. To reduce…
We report on further SLAC measurements of the Askaryan effect: coherent radio emission from charge asymmetry in electromagnetic cascades. We used synthetic rock salt as the dielectric medium, with cascades produced by GeV bremsstrahlung photons at the Final Focus Test Beam. We extend our prior discovery measurements to a wider range of parameter space and explore the effect in a dielectric medium of great potential interest to large scale ultra-high energy neutrino detectors: rock salt (halite), which occurs naturally in high purity formations containing in many cases hundreds of cubic km of w…
A room temperature heavy ion linac has been proposed as a new injector of CSRm (the main Cooler Storage Ring) at HIRFL (Heavy Ion Research Facility in Lanzhou), which is expected to improve the performance of HIRFL. The linac injector can supply heavy ion with maximum mass to charge ratio of 7 and injection kinetic energy of 7.272MeV/u for CSRm, and the pulsed beam intensity is 3emA with the duty factor of 3%. Compared with the present cyclotron injector SFC (Sector Focusing Cyclotron), the beam current from linac can be improved by 10-100 times. As the pre-accelerator of the linac, the 108.48…
A high-strength dual alpha+beta phase titanium alloy Ti-6Al-4V is utilized as a material for beam windows in several accelerator target facilities. However, relatively little is known about how material properties of this alloy are affected by high-intensity proton beam irradiation. With plans to upgrade neutrino facilities at J-PARC and Fermilab to over 1 MW beam power, the radiation damage in the window material will reach a few displacements per atom (dpa) per year, significantly above the ~0.3 dpa level of existing data. The RaDIATE collaboration has conducted a high intensity proton beam …
The Proton Improvement Plan II (PIP-II) at Fermilab is a program of upgrades to the injection complex. At its core is the design and construction of a CW-compatible, pulsed H- superconducting RF linac. To validate the concept of the front-end of such machine, a test accelerator (a.k.a. PXIE) is under construction. It includes a 10 mA DC, 30 KeV H- ion source, a 2 m-long Low Energy Beam Transport (LEBT), a 2.1 MeV CW RFQ, followed by a Medium Energy Beam Transport (MEBT) that feeds the first of 2 cryomodules increasing the beam energy to ~25 MeV, and a High Energy Beam Transport section (HEBT) …
