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arXiv 0911.3769math.STstat.TH
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利用平均似然比检验统计量检测空间聚类

Detection of spatial clustering with average likelihood ratio test statistics

Hock Peng Chan

摘要:

广义似然比(GLR)检验统计量常用于检测病例-对照和病例-人群数据集的空间聚类,以检查某个扫描窗口内显著大比例的病例。传统的空间扫描检验统计量取所有窗口上的上确界GLR值,而我们在这里考虑的平均似然比(ALR)检验统计量取GLR值的平均值。文献和本文的数值实验表明,ALR检验统计量比空间扫描统计量具有更高的功效。在本文中,我们开发了准确的尾部概率近似的ALR检验统计量,使我们能够绕过计算机密集型蒙特卡罗程序来估计$p$值。在针对协变量进行调整的模型中,这些Monte Carlo评估需要对参数进行初始拟合,这可能会导致$p$值估计值存在很大偏差。

英文摘要:

Generalized likelihood ratio (GLR) test statistics are often used in the detection of spatial clustering in case-control and case-population datasets to check for a significantly large proportion of cases within some scanning window. The traditional spatial scan test statistic takes the supremum GLR value over all windows, whereas the average likelihood ratio (ALR) test statistic that we consider here takes an average of the GLR values. Numerical experiments in the literature and in this paper show that the ALR test statistic has more power compared to the spatial scan statistic. We develop in this paper accurate tail probability approximations of the ALR test statistic that allow us to by-pass computer intensive Monte Carlo procedures to estimate $p$-values. In models that adjust for covariates, these Monte Carlo evaluations require an initial fitting of parameters that can result in very biased $p$-value estimates.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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