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arXiv 0907.2718math.DSq-bio.NC
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神经质量模型中的余维二分岔与韵律

Codimension Two Bifurcations and Rythms in Neural Mass Models

Jonathan Touboul, Olivier Faugeras

摘要:

颞叶癫痫(TemporalLobeepilepsy,TLE)是一种常见的慢性神经系统疾病,其特征是自发性反复发作,可通过脑电图(Electroencephalogram,EEG)记录在人群水平上观察到。本文总结了一些初步的工作,旨在从理论上了解这种类型的癫痫发作的发生和振荡活动的起源在一些经典的皮质柱模型。我们将这些节律活动与模型中的周期轨道集的结构相关联,从而与它们的分叉相关联。我们主要研究Jansen和Rit模型,并研究该模型的平衡点和圈的余维一、二和余维三分支。因此,我们可以理解癫痫样活动的显现系统的不同生物参数的影响,并观察在一定参数范围内α、δ和θ睡眠波的出现。然后,我们提出了一个非常快速的研究Wendling和Chauvel的模型,考虑到GABA A抑制性突触后电流。

英文摘要:

Temporal lobe epilepsy is one of the most common chronic neurological disorder characterized by the occurrence of spontaneous recurrent seizures which can be observed at the level of populations through electroencephalogram (EEG) recordings. This paper summarizes some preliminary works aimed to understand from a theoretical viewpoint the occurrence of this type of seizures and the origin of the oscillatory activity in some classical cortical column models. We relate these rhythmic activities to the structure of the set of periodic orbits in the models, and therefore to their bifurcations. We will be mainly interested Jansen and Rit model, and study the codimension one, two and a codimension three bifurcations of equilibria and cycles of this model. We can therefore understand the effect of the different biological parameters of the system of the apparition of epileptiform activity and observe the emergence of alpha, delta and theta sleep waves in a certain range of parameter. We then present a very quick study of Wendling and Chauvel's model which takes into account GABA A inhibitory postsynaptic currents.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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