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arXiv 0903.3083q-bio.NCphysics.bio-ph
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测量多个脉冲序列同步性

Measuring multiple spike train synchrony

T. Kreuz, D. Chicharro, R. G. Andrzejak, J. S. Haas, H. D. I. Abarbanel

摘要:

多个脉冲序列同步的措施是必不可少的,以研究问题,如尖峰定时的可靠性,网络同步,神经元编码。这些测量可以大致分为多变量测量和双变量测量的平均值。最新的双变量方法之一,ISI距离,采用瞬时峰间期的比率。在这项研究中,我们提出了两个扩展的ISI距离,直接平均的二元ISI距离和多元ISI多样性的变异系数的基础上。像原来的措施,这些扩展结合了许多理想的应用程序中的真实数据的属性。特别是,他们是参数自由,时间尺度独立,易于可视化的时间分辨的方式,我们说明了在体外记录从皮层神经元。使用模拟网络的Hindemash-Rose神经元作为一个控制配置,我们比较我们的方法在区分不同级别的多神经元脉冲序列同步的性能,其他六个先前公布的措施。我们展示并解释了为什么平均二元度量比多元度量表现得更好,以及为什么多元ISI多样性是多元方法中表现最好的。最后,在与依赖于移动窗口估计的标准方法的比较中,我们使用单单位猴子数据来证明我们的方法的瞬时性质的优点。

英文摘要:

Measures of multiple spike train synchrony are essential in order to study issues such as spike timing reliability, network synchronization, and neuronal coding. These measures can broadly be divided in multivariate measures and averages over bivariate measures. One of the most recent bivariate approaches, the ISI-distance, employs the ratio of instantaneous interspike intervals. In this study we propose two extensions of the ISI-distance, the straightforward averaged bivariate ISI-distance and the multivariate ISI-diversity based on the coefficient of variation. Like the original measure these extensions combine many properties desirable in applications to real data. In particular, they are parameter free, time scale independent, and easy to visualize in a time-resolved manner, as we illustrate with in vitro recordings from a cortical neuron. Using a simulated network of Hindemarsh-Rose neurons as a controlled configuration we compare the performance of our methods in distinguishing different levels of multi-neuron spike train synchrony to the performance of six other previously published measures. We show and explain why the averaged bivariate measures perform better than the multivariate ones and why the multivariate ISI-diversity is the best performer among the multivariate methods. Finally, in a comparison against standard methods that rely on moving window estimates, we use single-unit monkey data to demonstrate the advantages of the instantaneous nature of our methods.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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