病毒基因组中RNA二级结构预测的统计特性
Statistical properties of thermodynamically predicted RNA secondary structures in viral genomes
摘要：
通过对1212个完整的病毒基因组中的1832个片段进行全面的研究，我们发现在病毒基因组中，在简单的随机零假设下，预测RNA二级结构的发夹结构比预期的更丰富。检测到的RNA二级结构的发夹结构存在于四组病毒的编码区和非编码区中，这四组病毒被分类为dsDNA、dsRNA、ssDNA和ssRNA。对于所有组的RNA二级结构的发夹结构检测更频繁地比预期的随机零假设在非编码区，而不是在编码区。然而，潜在的RNA二级结构也存在于dsDNA组的编码区中。事实上，我们检测到进化保守的RNA二级结构中的保守的编码和非编码区的一大套完整的基因组的双链DNA疱疹病毒。
英文摘要：
By performing a comprehensive study on 1832 segments of 1212 complete genomes of viruses, we show that in viral genomes the hairpin structures of thermodynamically predicted RNA secondary structures are more abundant than expected under a simple random null hypothesis. The detected hairpin structures of RNA secondary structures are present both in coding and in noncoding regions for the four groups of viruses categorized as dsDNA, dsRNA, ssDNA and ssRNA. For all groups hairpin structures of RNA secondary structures are detected more frequently than expected for a random null hypothesis in noncoding rather than in coding regions. However, potential RNA secondary structures are also present in coding regions of dsDNA group. In fact we detect evolutionary conserved RNA secondary structures in conserved coding and noncoding regions of a large set of complete genomes of dsDNA herpesviruses.
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