Selective accumulation of B-10 compound in tumour tissue is a fundamental condition for the achievement of BNCT (Boron Neutron Capture Therapy), since the effectiveness of therapy irradiation derives just from neutron capture reaction of B-10. Hence, the determination of the B-10 concentration ratio, between tumour and healthy tissue, and a control of this ratio, during the therapy, are essential to optimise the effectiveness of the BNCT, which it is known to be based on the selective uptake of B-10 compound. In this work, experimental methods are proposed and evaluated for the determination in vivo of B-10 compound in biological samples, in particular based on neutron radiography and gammaray spectroscopy by telescopic system. Measures and Monte Carlo calculations have been performed to investigate the possibility of executing imaging of the 10B distribution, both by radiography with thermal neutrons, using 6LiF/ZnS:Ag scintillator screen and a CCD camera, and by spectroscopy, based on the revelation of gamma-ray reaction products from B-10 and the H. A rebuilding algorithm has been implemented. The present study has been done for the standard case of B-10 uptake, as well as for proposed case in which, to the same carrier, is also synthesized Gd-157, in the amount of is used like a contrast agent in NMRI.
On the (un)effectiveness of Proton Boron Capture in Proton Therapy
我们目前的计算和模拟的作用，p+ $^{11}$ B $\to$ 3 $α$反应在质子治疗。这种反应最近被认为是负责肿瘤细胞的存活概率下降，当它们被低能质子照射时。然而，在所提出的硼载体（硼帽酸钠，Na $_{2}$ B $_{12}$ H $_{11}$ SH，简称BSH）的典型浓度水平下，即小于100 ppm，计算和蒙特卡罗模拟都表明，与该反应相关的剂量比由组织内的初级质子束递送的剂量低几个数量级。这些计算对质子硼捕获在增强质子治疗的治疗效果中发挥重要作用的说法提出了一些质疑，并建议应研究其他机制，以解释观察到的生存概率下降。
Neutron relative effectiveness factors in Boron Neutron Capture Therapy: estimation of their values from the secondary charged particles and evaluation of weighted kerma factors for a standard tissue
Quantum Mechanical Analysis of Neutron Wavefunction Overlap and Nuclear Interaction Probability with Carborane Cage ($^{10}$B10) in Boron Neutron Capture Therapy
National Kaohsiung University of Science and Technology（国立高雄科技大学）；National Taipei University of Technology（国立台北科技大学）；The Affiliated Senior High School of National Taiwan Normal University（台湾师范大学附属高级中学）
Distinct Radiobiological Responses to BNCT in SAS Oral Squamous Cell Carcinoma and MCF-7 Breast Cancer Cells
Key Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology（教育部辐射物理与技术重点实验室，核科学与技术研究所）；West China School of Basic Medical Sciences and Forensic Medicine（华西基础医学与法医学院）
Deep convolutional framelets for dose reconstruction in BNCT with Compton camera detector
Istituto Nazionale di Fisica Nucleare（国家核物理研究所）；Università degli Studi di Bari Aldo Moro（巴里阿尔多·莫罗大学）；Nanjing University of Science and Technology（南京理工大学）
Bragg-Curve Simulation of Carbon-Ion Beams for Particle-therapy Applications: a study with the GEANT4 toolkit
我们使用GEANT4 Monte Carlo MC Toolkit模拟碳离子束入射到水、组织和骨骼上，同时考虑到核碎裂反应。在增加初级射束的能量时，布拉格峰的位置转移到体模内部更深的位置。对于不同的材料，峰值位于沿束方向的较浅的深度处，并且随着电子密度NZ的增加而变得尖锐。随后，产生的深度剂量的布拉格曲线，然后基准与德国GSI的实验数据。计算结果与GSI实验数据具有较好的相关性，精度在0.02~0.08cm之间，为在重离子治疗计划中采用MC奠定了基础。Kolmogorov-Smirnov K-S检验从统计学的角度进一步确定了模拟数据与实验测量数据非常匹配。将入口处的二维等剂量线与峰值位置周围和超出峰值的尾部区域中的等剂量线进行比较，表明由于二次剂量，与水和组织相比，骨产生更多剂量。在水中，结果表明，每个碎片沉积的最大能量主要归因于次级碳离子，其次是次级硼和铍。此外，产生的质子数是最高的，从而对尾区的总剂量沉积做出最大贡献。最后分析了中子和光子的关联谱。平均中子能量值为16.29 MeV，次级γ射线为1.03 MeV。然而，中子剂量被认为是可以忽略不计的总剂量相比，由于其较长的范围。
