用于重带电粒子放射治疗的射束定制装置的计算建模
Computational modeling of beam-customization devices for heavy-charged-particle radiotherapy
摘要：
针对质子和重离子放射治疗计划中的剂量分布计算问题，基于束流传输相空间理论，提出了一种基于准直器和距离补偿滤波器的束流定制模型。在传统的笔形波束算法中，笔形波束的独立处理导致在大视场中间的非物理准直器高度依赖性，这通过由笔形波束矩阵的生成、传输、准直、再生、范围补偿和边缘锐化过程组成的框架来解决。经验证，该模型与组合准直碳离子束的单个准直器半影中亚毫米水平的测量和分析估计一致。模型计算快速、准确，并且易于应用于治疗计划中的双射束算法，具有组合准直的能力，以充分利用射束定制设备。
英文摘要：
A model for beam customization with collimators and a range-compensating filter based on the phase-space theory for beam transport is presented for dose distribution calculation in treatment planning of radiotherapy with protons and heavier ions. Independent handling of pencil beams in conventional pencil-beam algorithms causes unphysical collimator-height dependence in the middle of large fields, which is resolved by the framework comprised of generation, transport, collimation, regeneration, range-compensation, and edge-sharpening processes with a matrix of pencil beams. The model was verified to be consistent with measurement and analytic estimation at a submillimeter level in penumbra of individual collimators with a combinational-collimated carbon-ion beam. The model computation is fast, accurate, and readily applicable to pencil-beam algorithms in treatment planning with capability of combinational collimation to make best use of the beam-customization devices.
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