利用微机械布朗棘轮装置传输DNA
DNA transport by a micromachined Brownian ratchet device
摘要：
我们已经用微机械加工了一个硅芯片装置，它用一个布朗棘轮来传输DNA，这个布朗棘轮可以纠正微观粒子的布朗运动。DNA 50聚体的输运性质与理论预测一致，DNA扩散常数与以前的实验结果一致。这种类型的微机器可以为DNA或其他带电物质提供通用泵或分离组件，作为微尺度芯片实验室的一部分。具有减小的特征尺寸的设备可以产生基于尺寸的DNA分子分离，其应用包括检测单核苷酸多态性。
英文摘要：
We have micromachined a silicon-chip device that transports DNA with a Brownian ratchet that rectifies the Brownian motion of microscopic particles. Transport properties for a DNA 50mer agree with theoretical predictions, and the DNA diffusion constant agrees with previous experiments. This type of micromachine could provide a generic pump or separation component for DNA or other charged species as part of a microscale lab-on-a-chip. A device with reduced feature size could produce a size-based separation of DNA molecules, with applications including the detection of single nucleotide polymorphisms.
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