光热分子阱
Optothermal Molecule Trap
摘要：
热泳使分子沿温度梯度移动，通常是从热到冷。我们叠加流体流动与热泳分子流在良好定义的微流体条件下，通过荧光显微镜成像。在两种流动方向相反的区域，DNA被捕获并积累了16倍。预期有800倍的强蓄积，但捕获动力学缓慢。实验同样描述了一个三维和一维的分析模型。作为一个应用程序，我们展示了如何径向收敛的温度场限制短DNA到一个10微米的小斑点。
英文摘要：
Thermophoresis moves molecules along temperature gradients, typically from hot to cold. We superpose fluid flow with thermophoretic molecule flow under well defined microfluidic conditions, imaged by fluorescence microscopy. DNA is trapped and accumulated 16-fold in regions where both flows move in opposite directions. Strong 800-fold accumulation is expected, however with slow trapping kinetics. The experiment is equally described by a three-dimensional and one-dimensional analytical model. As an application, we show how a radially converging temperature field confines short DNA into a 10 um small spot.
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