Real time noninvasive cancer diagnostics

使用随机森林机器学习的无创急性骨筋膜室综合征诊断

Noninvasive Acute Compartment Syndrome Diagnosis Using Random Forest Machine Learning

本研究提出一种基于随机森林机器学习模型的无创急性骨筋膜室综合征诊断设备，利用皮肤表面的力敏电阻器替代压力读数进行检测，在运动和静止场景下准确率达98%，制造成本低，有望满足临床准确性标准。

宫颈癌治疗反应的多模态与时间分析

Multi-Modality and Temporal Analysis of Cervical Cancer Treatment Response

本文提出利用多模态医学影像与GLCM纹理分析（特别是对比度特征）预测宫颈癌治疗反应，为精准诊断、个性化干预及优化治疗策略提供了有效方法。

Optical detection of fractal dimensions of MUC13 stained pancreatic tissues for cancer diagnostics

Transmission intensity of a thin tissue sample produce intensity distribution that is proportional to the refractive index pattern in the thin slice, in turn reflects mass density pattern, and using the intensity pattern, fractal dimension can be calculated. In this paper, we report fractal dimension analyses of MUC13 stained pancreatic cancer tissues. Pancreatic cancer is deadliest due to its physical orientation, and no prominent chemical change till the late stages of cancer. The presence of pancreatic cancer can be detected using MUC13, however this fails to explain about the stages of can…

Prompt gamma ray diagnostics and enhanced hadron-therapy using neutron-free nuclear reactions

We propose a series of simulations about the potential use of Boron isotopes to trigger neutron-free (aneutronic) nuclear reactions in cancer cells through the interaction with an incoming energetic proton beam, thus resulting in the emission of characteristic prompt gamma radiation (429 keV, 718 keV and 1435 keV). Furthermore assuming that the Boron isotopes are absorbed in cancer cells, the three alpha-particles produced in each p-11B aneutronic nuclear fusion reactions can potentially result in the enhancement of the biological dose absorbed in the tumor region since these multi-MeV alpha-p…

Proton CT -- a novel diagnostic tool in cancer therapy

Radiotherapy is one of the main methods in the successful treatment of cancer. The tumor is irradiated with photons or charged particles (e.g. protons), and in the case of massive charged particles, the treatment results in less unnecessary dose outside the tumor and therefore less side effects for the patient and a faster recovery. However, the dose planning of hadron therapy is calculated from photon CT measurements, which results in large uncertainties in the planning and therefore in a necessary enlargement of the treatment area. This uncertainty can be reduced by performing the CT scan us…

Towards non-invasive cancer diagnostics and treatment based on electromagnetic fields, optomechanics and microtubules

In this paper, we discuss biological effects of electromagnetic (EM) fields in the context of cancer biology. In particular, we review the nanomechanical properties of microtubules (MTs), the latter being one of the most successful targets for cancer therapy. We propose an investigation on the coupling of electromagnetic radiation to mechanical vibrations of MTs as an important basis for biological and medical applications. In our opinion optomechanical methods can accurately monitor and control the mechanical properties of isolated MTs in a liquid environment. Consequently, studying nanomecha…