Diagnosis of human breast cancer through wavelet transform of polarized fluorescence

Characteristic spectral features of the polarized fluorescence of human breast cancer in the wavelet domain

Wavelet transform of polarized fluorescence spectra of human breast tissues is found to localize spectral features that can reliably differentiate normal and malignant tissue types. The intensity differences of parallel and perpendicularly polarized fluorescence spectra are subjected to investigation, since the same is relatively free of the diffusive background. A number of parameters, capturing spectral variations and subtle changes in the diseased tissues in the visible wavelength regime, are clearly identifiable in the wavelet domain. These manifest both in the average low pass and high fr…

Application of computational breast phantoms to evaluate reconstruction methods for fluorescence molecular tomography

Fluorescence molecular tomography (FMT) has potential of providing high contrast images for breast tumor detection. Computational phantom provides a convenient way to a wide variety of fluorophore distribution configurations in patients and perform comprehensive evaluation of the imaging systems and methods for FMT. In this study, a digital breast phantom was used to compare the performance of a novel sparsity-based reconstruction method and Tikhonov regularization method for resolving tumors with different amount of separation. The results showed that the proposed sparse reconstruction method…

用于人类乳腺癌细胞表征的荧光增强光动力评估

Fluorescence-enhanced photodynamic assessments for human breast cancer cell characterizations

本研究基于荧光增强光动力表征，利用5-ALA诱导的PpIX荧光信号和PCA多变量分析，区分乳腺癌原发与转移阶段的MDA细胞，证实了该技术在及时检测乳腺癌中的高潜力。

光片显微镜评估癌症病理：当前观点与未来趋势

Light-sheet microscopy to assess cancer pathology: current views and future trends

本文综述了光片荧光显微镜在癌症病理分析中的当前应用，并探讨其整合入临床流程以实现完整标本高通量三维成像，从而提升诊断精度和揭示肿瘤结构形态的潜力。