多相膜管的Fission
Fission of a multiphase membrane tube
摘要：
细胞内运输的一种常见机制是利用膜的受控变形来产生球形或管状芽。虽然均质膜的基本物理性质是相对众所周知的，但膜内不均匀性的影响是非常活跃的研究领域。特别是富含某些脂质的膜结构域备受关注，在这封信中，我们研究了这些结构域对膜管形状和命运的影响。最近的实验表明，强制脂质相分离可以触发管裂变，我们演示了如何可以理解纯粹从域之间的弹性常数的差异。此外，所提出的模型预测的时间尺度裂变同意与实验结果。
英文摘要：
A common mechanism for intracellular transport is the use of controlled deformations of the membrane to create spherical or tubular buds. While the basic physical properties of homogeneous membranes are relatively well-known, the effects of inhomogeneities within membranes are very much an active field of study. Membrane domains enriched in certain lipids in particular are attracting much attention, and in this Letter we investigate the effect of such domains on the shape and fate of membrane tubes. Recent experiments have demonstrated that forced lipid phase separation can trigger tube fission, and we demonstrate how this can be understood purely from the difference in elastic constants between the domains. Moreover, the proposed model predicts timescales for fission that agree well with experimental findings.
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