随机共振作为离子通道集合体的集体性质

生物细胞膜离子通道集合体精确可解模型的集体性质

Collective Properties of the Exactly Solvable Model of Ion-Channel Assemblies in a Biological Cell Membrane

提出了跨细胞膜形成的离子通道系统的行为。首先引入具有无限耦合的无限数量的通道作为详细推导热平衡概率分布和相变分类的参考点。接下来讨论有限系统中的涨落。我们提出了一个新的，阶梯状的离子通道切换模型，我们提供的分析结果。并给出了该模型与实验的关系。最后，借助精确对角化技术对有限通道数膜的主方程进行了数值分析。特别是，亚稳态溶液的衰减时间估计。所得结果与微扰法所得结果不一致，用所提出的冻结扩散法解释了这一差异。

活性极性聚合物组装体中的集体动力学

Collective Dynamics in Active Polar Polymer Assemblies

该研究通过含时间随机性的活性梯度驱动TDAPs，揭示位阻互锁导致低浓度下层级缠结与凝胶化的新机制。

Clustering and ordering in cell assemblies with generic asymmetric aligning interactions

Collective cell migration plays an essential role in various biological processes, such as development or cancer proliferation. While cell-cell interactions are clearly key determinants of collective cell migration -- in addition to individual cells self-propulsion -- the physical mechanisms that control the emergence of cell clustering and collective cell migration are still poorly understood. In particular, observations have shown that binary cell-cell collisions generally lead to anti-alignement of cell polarities and separation of pairs -- a process called contact inhibition of locomotion …

可兴奋膜中的通道噪声和同步化

Channel noise and synchronization in excitable membranes

使用随机推广的Hodgkin Huxley模型，我们认为内在通道噪声的可兴奋膜的尖峰活动和外部施加的周期性信号之间的同步的影响。对于小块，即，当通道噪声主导可激发动力学时，我们发现了内禀相干共振现象。在这种情况下，相对规则的尖峰行为实际上与所施加的外部驱动无关;因此不会发生同步。然而，仅对于足够大的离子通道组件才发生同步。因此，神经元信号处理可能植根于离子通道的最佳大组件的集体性质。

pH Sensing by Lipids in Membranes: The Fundamentals of pH-driven Migration, Polarization and Deformations of Lipid Bilayer Assemblies

Most biological molecules contain acido-basic groups that modulate their structure and interactions. A consequence is that pH gradients, local heterogeneities and dynamic variations are used by cells and organisms to drive or regulate specific biological functions including energetic metabolism, vesicular traffic, migration and spatial patterning of tissues in development. While the direct or regulatory role of pH in protein function is well documented, the role of hydrogen and hydroxyl ions in modulating the properties of lipid assemblies such as bilayer membranes is only beginning to be unde…

一维基底上细胞集合体的活性自旋模型

Active spin model for cell assemblies on 1D substrates

受微图案化准一维基底的细胞实验启发，本研究提出纳入自推进、极性切换、细胞吸引与CIL作用的活性自旋模型，解析不同极限下的簇尺寸分布，揭示平均簇尺寸的非单调依赖特性。