细胞受体的聚集和信号传导
Clustering and Signalling of Cell Receptors
摘要：
作为对配体结合的响应，跨膜细胞受体通常在信号传导过程中增强它们的聚集或寡聚化。在这里，我们提出了一个统计力学模型，它结合了聚类和信号方面。在这个模型中，受体漂浮在表面上，而对于两个相邻的受体，存在依赖于它们的构象状态的相互作用能。另一方面，受体的配体结合改变了两种构象状态之间的能量差。由于热涨落，聚类和信号的影响是统计平均量。该模型简化为一个带有随机场的浮动伊辛模型。我们计算的巨正则系综平均场的方法，使用Hubbard-Stratonovich变换和复制方法的信令。还进行了蒙特卡罗模拟。在我们的模型中获得了基本的生物特征。
英文摘要：
As a response to ligand binding, transmembrane cell receptors often enhance their clustering, or oligomerization, during the signalling process. Here we present a statistical mechanical model which combines the aspects of clustering and signalling. In this model, receptors float on the surface, while for two neighboring receptors, there is an interaction energy dependent on their conformational states. On the other hand, ligand binding of a receptor shifts the energy difference between the two conformational states. Due to thermal fluctuation, the effects of clustering and signalling are statistical average quantities. This model reduces to a floating Ising model with a random field. We calculate the signalling in a grand canonical ensemble mean field approach, using Hubbard-Stratonovich transformation and replica method. Monte Carlo simulations are also performed. Essential biological features are obtained in our model.
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