正常血细胞计数的大尺度不变波动：是临界状态的标志吗？
Large Scale-Invariant Fluctuations in Normal Blood Cell Counts: A sign of criticality?
摘要：
所有类型的血细胞都是由骨髓中一小部分自我维持的多能干细胞分化形成的。尽管关于这些细胞的分裂、分化、定型和成熟的分子方面的信息非常丰富，但对于整个系统的动态以及它如何在整个生命过程中将这种复杂的“生态学”维持在观察到的正常范围内，人们却知之甚少。在这里，我们报告了意外的大，无标度，波动检测到的第一个长期分析的日常变化的健康动物的血细胞计数超过一千天。这种尺度不变性不能用当前的理论模型来解释，并且类似于自组织临界性所描述的一些场景。
英文摘要：
All types of blood cells are formed by differentiation from a small self-maintaining population of pluri-potential stem cells in the bone marrow. Despite abundant information on the molecular aspects of division, differentiation, commitment and maturation of these cells, comparatively little is known about the dynamics of the system as a whole, and how it works to maintain this complex ``ecology'' in the observed normal ranges throughout life. Here we report unexpected large, scale-free, fluctuations detected from the first long-term analysis of the day-to-day variability of a healthy animal's blood cell counts measured over one thousand days. This scale-invariance cannot be accounted for by current theoretical models, and resembles some of the scenarios described for self-organized criticality.
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