噬菌体λ的稳定性难题
Stability Puzzles in Phage Lambda
摘要：
噬菌体λ中的溶原性维持开关是生命系统中分子水平上的计算、命令和控制的最简单例子之一。如果感染E.在大肠杆菌中，病毒进入溶原途径，抑制其发育功能，并将其DNA整合到宿主染色体中。在这种状态下，原噬菌体可以被动地复制许多代E。杆菌事实上，这种受抑制的状态本质上比编码阻遏物的基因更稳定。我们开发了一种数学形式主义来预测这种表观遗传状态的稳定性，从分子组分的亲和力。我们应用该模型的行为最近发表的突变体在右运营商复杂的lambda，并发现报告的稳定性表明，目前的开关是不完整的。这里描述的方法应该普遍适用于表达状态的稳定性
英文摘要：
The lysogeny maintenance switch in phage lambda is one of the simplest examples on the molecular level of computation, command and control in a living system. If, following infection of the bacterium E. coli, the virus enters the lysogenic pathway, it represses its developmental functions, and integrates its DNA into the host chromosome. In this state the prophage may be passively replicated for many generations of E. coli. In fact, this repressed state is intrinsically more stable than the gene encoding the repressor. We develop a mathematical formalism to predict the stability of such epigenetic states from affinities of the molecular components. We apply the model to the behavior of recently published mutants at the right operator complex of lambda, and find that the reported stability indicates that the current view of the switch is incomplete. The approach described here should be generally applicable to the stability of expressed states
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