λ型肠杆菌噬菌体中溶原性到裂解性转变的孤子和物理机制
Solitons and Physics of the Lysogenic to Lytic Transition in Enterobacteria Lambda Phage
摘要：
λ噬菌体是典型的温和噬菌体。其溶原性和裂解性生命周期反映了DNA结合CI和CRO蛋白之间的竞争。在这里，我们解决这个过渡的能量函数，描绘的骨干作为一个多孤子配置方面的物理。单个孤子的精度远远超过了实验确定的蛋白质构象的B因子精度，这使我们有信心得出结论，四个环路中的三个是两个位置紧密的孤子的复合物。唯一的例外是抑制性DNA结合转向，它是主链的唯一单孤子构型。当我们比较的孤子与蛋白质数据库，我们发现，前面的DNA识别螺旋是唯一的CI蛋白，促使我们得出结论，溶源裂解过渡是由于鞍结分叉涉及孤子-反孤子湮灭，删除了第一个循环。
英文摘要：
The lambda phage is a paradigm temperate bacteriophage. Its lysogenic and lytic life cycles echo competition between the DNA binding CI and CRO proteins. Here we address the Physics of this transition in terms of an energy function that portrays the backbone as a multi-soliton configuration. The precision of the individual solitons far exceeds the B-factor accuracy of the experimentally determined protein conformations giving us confidence to conclude that three of the four loops are each composites of two closely located solitons. The only exception is the repressive DNA binding turn, it is the sole single soliton configuration of the backbone. When we compare the solitons with the Protein Data Bank we find that the one preceding the DNA recognition helix is unique to the CI protein, prompting us to conclude that the lysogenic to lytic transition is due to a saddle-node bifurcation involving a soliton-antisoliton annihilation that removes the first loop.
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