机械信号与全能性和前期神经状态：胚胎和癌症拓展发育物理学的前沿
Mechanical cues for totipotency and the preneural state: embryo and cancer expanding the frontiers of developmental physics
AI总结：
本文探讨机械信号在细胞分化及胚胎发育和癌症中的作用，提出机械生物学对疾病治疗的临床意义。
摘要：
本文提出物理学在细胞分化中的核心作用，揭示受精卵的全能性本质。全能性是一种持久的机械记忆，保存了动物形态发生的基本力学记录。本文研究胚胎发育和癌症中细胞分化的机械和生物物理途径，将其视为密切相关的生物和机械过程。借鉴进化历史，提出动物神经系统出现的生物物理机制。通过将物理原理与细胞分化联系起来，本文将机械生物学定位为创新的支柱，对癌症等疾病具有高影响的临床意义。
英文摘要：
In this article, I advance the idea that physics plays a central role in cell differentiation and makes fundamental contributions to morphogenesis, revealing the totipotent nature of the zygote. Totipotency is a persistent mechanical memory that preserves the biomechanical records of animal morphogenesis. I examine the mechanical and biophysical pathways underlying cell differentiation in embryonic development and cancer, treating them as closely related biological and mechanical processes. Drawing inspiration from evolutionary history, I also propose a biophysical mechanism for the emergence of the animal nervous system. By linking physical principles to cellular differentiation, this review positions mechanobiology as a pillar of innovation with high-impact clinical implications for diseases such as cancer.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
